T-Cell Non-Hodgkin Lymphomas: Spectrum of Disease and the Role of Imaging in the Management of Common Subtypes

T-cell non-Hodgkin lymphomas (NHLs) are biologically diverse, uncommon malignancies characterized by a spectrum of imaging findings according to subtype. The purpose of this review is to describe the common subtypes of T-cell NHL, highlight important differences between cutaneous, various peripheral and precursor subtypes, and summarize imaging features and the role of imaging in the management of this diverse set of diseases

Teaching cancer imaging in the era of precision medicine: Looking at the big picture

The role of imaging in cancer diagnosis and treatment has evolved at the same rapid pace as cancer management. Over the last twenty years, with the advancement of technology, oncology has become a multidisciplinary field that allows for researchers and clinicians not only to create individualized treatment options for cancer patients, but also to evaluate patients\u27 response to therapy with increasing precision. Familiarity with these concepts is a requisite for current and future radiologists, as cancer imaging studies represent a significant and growing component of any radiology practice, from tertiary cancer centers to community hospitals. In this review we provide the framework to teach cancer imaging in the era of genomic oncology. After reading this article, readers should be able to illustrate the basics cancer genomics, modern cancer genomics, to summarize the types of systemic oncologic therapies available, their patterns of response and their adverse events, to discuss the role of imaging in oncologic clinical trials and the role of tumor response criteria and to display the future directions of oncologic imaging

Galaxy Merger Statistics and Inferred Bulge-to-Disk Ratios in Cosmological SPH Simulations

We construct merger trees for galaxies identified in a cosmological hydrodynamical simulation and use them to characterize predicted merger rates as a function of redshift, galaxy mass, and merger mass ratio. At z=0.3, we find a mean rate of 0.054 mergers per galaxy per Gyr above a 1:2 mass ratio threshold for massive galaxies (baryonic mass above 6.4E10 \Msun), but only 0.018 / Gyr for lower mass galaxies. The mass ratio distribution is proportional to R_merg^-1.2 for the massive galaxy sample, so high mass mergers dominate the total merger growth rate. The predicted rates increase rapidly with increasing redshift, and they agree reasonably well with observational estimates. A substantial fraction of galaxies do not experience any resolved mergers during the course of the simulation, and even for the high mass sample only 50% of galaxies experience a greater than 1:4 merger since z=1. Typical galaxies thus have fairly quiescent merger histories. We assign bulge-to-disk ratios to simulated galaxies by assuming that mergers above a mass ratio threshold R_major convert stellar disks into spheroids. With R_major of 1:4, we obtain a fairly good match to the observed dependence of early-type fraction on galaxy mass. However, the predicted fraction of truly bulge-dominated systems (f_bulge} > 0.8) is small, and producing a substantial population of bulge-dominated galaxies may require a mechanism that shuts off gas accretion at late times and/or additional processes (besides major mergers) for producing bulges.Comment: submitted to MNRAS, 11 pages, 11 figures, a version of the paper with a high resolution version of Figure 2 at http://www.astro.umass.edu/~ari/pub.htm

Cancer of the Esophagus

This chapter in Cancer Concepts: A Guidebook for the Non-Oncologist presents an overview of esophageal cancer, including etiology, epidemiology, screening, pathology, staging, and treatment.https://escholarship.umassmed.edu/cancer_concepts/1027/thumbnail.jp

Simulating Subhalos at High Redshift: Merger Rates, Counts, and Types

Galaxies are believed to be in one-to-one correspondence with simulated dark matter subhalos. We use high-resolution N-body simulations of cosmological volumes to calculate the statistical properties of subhalo (galaxy) major mergers at high redshift (z=0.6-5). We measure the evolution of the galaxy merger rate, finding that it is much shallower than the merger rate of dark matter host halos at z>2.5, but roughly parallels that of halos at z<1.6. We also track the detailed merger histories of individual galaxies and measure the likelihood of multiple mergers per halo or subhalo. We examine satellite merger statistics in detail: 15%-35% of all recently merged galaxies are satellites and satellites are twice as likely as centrals to have had a recent major merger. Finally, we show how the differing evolution of the merger rates of halos and galaxies leads to the evolution of the average satellite occupation per halo, noting that for a fixed halo mass, the satellite halo occupation peaks at z~2.5.Comment: 17 pages, 12 figures, accepted in MNRAS, version matches published on

History of Galaxy Interactions and their Impact on Star Formation over the Last 7 Gyr from GEMS

We perform a comprehensive estimate of the frequency of galaxy mergers and their impact on star formation over z~0.24--0.80 (lookback time T_b~3--7 Gyr) using 3698 (M*>=1e9 Msun) galaxies with GEMS HST, COMBO-17, and Spitzer data. Our results are: (1) Among 790 high mass (M*>=2.5e10 Msun) galaxies, the visually-based merger fraction over z~0.24--0.80, ranges from 9%+-5% to 8%+-2%. Lower limits on the major and minor merger fractions over this interval range from 1.1% to 3.5%, and 3.6% to 7.5%, respectively. This is the first approximate empirical estimate of the frequency of minor mergers at z<1. For a visibility timescale of ~0.5 Gyr, it follows that over T_b~3--7 Gyr, ~68% of high mass systems have undergone a merger of mass ratio >1/10, with ~16%, 45%, and 7% of these corresponding respectively to major, minor, and ambiguous `major or minor' mergers. The mean merger rate is a few x 1e-4 Gyr-1 Mpc-3. (2) We compare the empirical merger fraction and rate for high mass galaxies to a suite of Lambda CDM-based models: halo occupation distribution models, semi-analytic models, and hydrodynamic SPH simulations. We find qualitative agreement between observations and models such that the (major+minor) merger fraction or rate from different models bracket the observations, and show a factor of five dispersion. Near-future improvements can now start to rule out certain merger scenarios. (3) Among ~3698 M*>=1e9 Msun galaxies, we find that the mean SFR of visibly merging systems is only modestly enhanced compared to non-interacting galaxies over z~0.24--0.80. Visibly merging systems only account for less than 30% of the cosmic SFR density over T_b~3--7 Gyr. This suggests that the behavior of the cosmic SFR density over the last 7 Gyr is predominantly shaped by non-interacting galaxies.Comment: Accepted for Publication in the Astrophysical Journal. 17 pages of text, 21 figures, 3 tables. Uses emulateapj5.st

The Preclinical Natural History of Serous Ovarian Cancer: Defining the Target for Early Detection

Pat Brown and colleagues carry out a modeling study and define what properties a biomarker-based screening test would require in order to be clinically useful

The mammalian centrosome and its functional significance

Primarily known for its role as major microtubule organizing center, the centrosome is increasingly being recognized for its functional significance in key cell cycle regulating events. We are now at the beginning of understanding the centrosome’s functional complexities and its major impact on directing complex interactions and signal transduction cascades important for cell cycle regulation. The centrosome orchestrates entry into mitosis, anaphase onset, cytokinesis, G1/S transition, and monitors DNA damage. Recently, the centrosome has also been recognized as major docking station where regulatory complexes accumulate including kinases and phosphatases as well as numerous other cell cycle regulators that utilize the centrosome as platform to coordinate multiple cell cycle-specific functions. Vesicles that are translocated along microtubules to and away from centrosomes may also carry enzymes or substrates that use centrosomes as main docking station. The centrosome’s role in various diseases has been recognized and a wealth of data has been accumulated linking dysfunctional centrosomes to cancer, Alstrom syndrome, various neurological disorders, and others. Centrosome abnormalities and dysfunctions have been associated with several types of infertility. The present review highlights the centrosome’s significant roles in cell cycle events in somatic and reproductive cells and discusses centrosome abnormalities and implications in disease