2 research outputs found
Delivering Timely Extension Information with the Agronomic Crops Team in Ohio
The Agronomic Crops Team was formed in 1995 to provide an Extension program that linked all disciplines together in an attempt to provide an integrated delivery mechanism designed to address all producer needs in a timely fashion. The team provides a newsletter, Web site, agronomy meetings and workshops, and a satellite broadcast to better serve state clientele. To date, the impact of the Agronomic Crops Team has been substantial, reaching managers of over 2.6 million acres of production ground in the state with an economic impact of over $11 million
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Configurational entropy is an intrinsic driver of tissue structural heterogeneity
Tissues comprise ordered arrangements of cells that can be surprisingly disordered in their details. How the properties of single cells and their microenvironment contribute to the balance between order and disorder at the tissue-scale remains poorly understood. Here, we address this question using the self-organization of human mammary organoids as a model. We find that organoids behave like a dynamic structural ensemble at the steady state. We apply a maximum entropy formalism to derive the ensemble distribution from three measurable parameters - the degeneracy of structural states, interfacial energy, and tissue activity (the energy associated with positional fluctuations). We link these parameters with the molecular and microenvironmental factors that control them to precisely engineer the ensemble across multiple conditions. Our analysis reveals that the entropy associated with structural degeneracy sets a theoretical limit to tissue order and provides new insight for tissue engineering, development, and our understanding of disease progression