Communication as a juridical method. Hermeneutics and analytics in the communicational Theory of Law

The existence of Law depends also on legal communication, a good method can rationalize and facilitate the processes of communication, in other words, the understanding of the meaning and the structural and conceptual interpretation of the legal message. This is the objective of the analytical hermeneutic method as a communicational method, this is one of the objectives of the TCD, to provide the jurist with tools, to provide a theoretical and methodological framework useful for his work, both scientific and practical. The fundamental purpose throughout this research work has been to show how in the same paradigm of communication methodical models are given that, if applied in the development of the juridical phenomenon, can allow us a more rational juridical communication. "Communication as a juridical method" is therefore a mere constructive proposal, the purpose of which is a beneficial use for all those who operate with the law: jurists and not jurists

A comprehensive system for semantic spatiotemporal assessment of risk in urban areas

AbstractRisk assessment of urban areas aims at limiting the impact of harmful events by increasing awareness of their possible consequences. Qualitative risk assessment allows to figure out possible risk situations and to prioritize them, whereas quantitative risk assessment is devoted to measuring risks from data, in order to improve preparedness in case of crisis situations. We propose an automatic approach to comprehensive risk assessment. This leverages on a semantic and spatiotemporal representation of knowledge of the urban area and relies on a software system including: a knowledge base; two components for quantitative and qualitative risk assessments, respectively; and a WebGIS interface. The knowledge base consists of the TERMINUS domain ontology, to represent urban knowledge, and of a geo‐referenced database, including geographical, environmental and urban data as well as temporal data related to the levels of operation of city services. CIPcast DSS is the component devoted to quantitative risk assessment, and WS‐CREAM is the component supporting qualitative risk assessment based on computational creativity techniques. Two case studies concerning the city of Rome (Italy) show how this approach can be used in a real scenario for crisis preparedness. Finally, we discuss issues related to plausibility of risks and objectivity of their assessment

Modeling Resilience in Electrical Distribution Networks

Electrical distribution networks deliver a fundamental service to citizens. However, they are still highly vulnerable to natural hazards as well as to cyberattacks; therefore, additional commitment and investments are needed to foster their resilience. Toward that, this paper presents and proposes the use of a complex simulation model, called reconfiguration simulator (RecSIM), enabling to evaluate the effectiveness of resilience enhancement strategies for electric distribution networks and the required resources to implement them. The focus is, in particular, on one specific attribute of resilience, namely, the readiness, i.e., the promptness and efficiency to recover the service functionality after a crisis event by managing and deploying the available resources rapidly and effectively. RecSIM allows estimating how and to what extent technological, topological, and management issues might improve electrical distribution networks’ functionality after the occurrence of accidental faults, accounting for interdependency issues and reconfiguration possibilities. The viability of implementing RecSIM on a real and large urban network is showcased in the paper with reference to the study case of the electrical distribution network (EDN) of Rome city

Glyphozines and treatment of cardiac disease

Glyphozines also called SGLT2 inhibitors, are a new class of agents that inhibit reabsorption of glucose in the kidney, in proximal tubules, and therefore lower blood sugar. They act by inhibiting sodiumglucose transport protein 2 (SGLT2). Glyphozines are used in the treatment of type II diabetes mellitus. In studies with canagliflozin, a member of this class, the medication was found to enhance blood sugar control as well as reduce body weight and systolic and diastolic blood pressure. In addition to regulate blood glucose, recent studies have shown that glyphozines have important positive cardiovascular benefits, such as weight loss, decreased volaemia and PA, reduced triglycerides, natriuresis and improved endothelial wall dysfunction. Clinical studies have shown reduction in deaths from cardiovascular events among diabetic patients treated with glyphozines. At the moment these drugs are being studied for an extension of the therapeutic indication also for cardiovascular diseases such as heart failure. In this review, we discuss the class of SGLT2 inhibitors in the treatment of diabetes, and studies focused on their possible role in the treatment of cardiac disease

Identification of protein-protein interactions of human HtrA1.

The human heat shock protein HtrA1, a member of the HtrA family of serine proteases, is a evolutionarily highly conserved factor which displays a widespread pattern of expression. The yeast two-hybrid technique was employed to identify new cellular proteins physically interacting with HtrA1, and thus potential targets of this serine protease. An enzymatically inactive HtrA1 point mutant, HtrA1-S328A, was generated and used as bait in a yeast two-hybrid system. Fifty-two plasmids were isolated from primary positive yeast clones. Subsequent sequencing and BLAST analysis revealed cDNAs encoding for 13 different proteins. These putative binding partners of HtrA1 appeared to be a) components of extracellular matrix; b) factors related to signal pathways, and c) unknown proteins. Among the 13 positive clones identified and reported here, it is worth of note that the interaction of HtrA1 with tubulin and collagen (extracellular matrix proteins) and with tuberin (cytoplasmic protein) is confirmed by other studies, and this further supports previous findings in which HtrA1 can be found active as an intracytoplasmic protein or as secreted protein as well

Analysis of the influence of flange thickness, web thickness and heat input on angular distortions in fillet joints

Este trabalho utilizou metodologia proposta por teorias de Projeto de Experimentos para quantificar o efeito da energia de soldagem, espessura da aba e espessura da alma na distorção angular em juntas de filete soldadas pelo processo MIG/MAG com modo de transferência curto-circuito. A Análise de Variância identificou como significativos o efeito da energia de soldagem, da espessura da aba e a interação dos fatores energia de soldagem e espessura da aba. Observou-se menores distorções para a combinação de maior energia de soldagem e menor espessura de aba, e para menor energia de soldagem e maior espessura de aba. Adicionalmente, demonstrou-se que o gradiente de temperatura na aba da junta não determina a máxima distorção angular, e sim a máxima temperatura atingida na superfície inferior da aba, com máxima distorção angular obtida para temperatura atingida de 425 °C em ponto na superfície inferior da aba e paralelo à margem do cordão.This work uses a methodology proposed by Experimental Design theories to quantify the effect of heat input, flange thickness and web thickness on angular distortion in welded T- joints by the MIG / MAG process with short-circuit transfer mode. The analysis of Variance identified as significant the effect of the heat input, the thickness of the flange and the interaction of the factors of heat input and thickness of the flange. Minimum distortions were observed for the combination of higher heat input and lower flange thickness, and for lower heat input and higher flange thickness. Additionally, it was demonstrated that the temperature gradient in the flange does not determine the maximum angular distortion, but the maximum temperature reached in the lower surface of the flange, with maximum angular distortion obtained for a temperature reached of 425 °C in point in the lower surface of the flange and parallel to the edge of the weld bead

A low-power high-speed InP microdisk modulator heterogeneously integrated on a SOI waveguide

We report on the modulation characteristics of indium phosphide (InP) based microdisks heterogeneously integrated on a silicon–on–insulator (SOI) waveguide. We present static extinction ratios and dynamic operation up to 10 Gb/s. Operation with a bit–error rate below 1 × 10-9 is demonstrated at 2.5, 5.0 and 10.0 Gb/s and the performance is compared with that of a commercial modulator. Power penalties are analyzed with respect to the pattern length. The power consumption is calculated and compared with state–of–the–art integrated modulator concepts. We demonstrate that InP microdisk modulators combine low–power and low–voltage operation with low footprint and high–speed. Moreover, the devices can be fabricated using the same technology as for lasers, detectors and wavelength converters, making them very attractive for co–integration

Loss of renal function in the elderly italians: a physiologic or pathologic process?

Abstract BACKGROUND: Nowadays it seems that chronic kidney disease (CKD) is outbreaking, mostly in the elderly participants. The aim of this study was to assess the progression of CKD in different ages. METHODS: We conducted a monocentric, retrospective, observational study enrolling 116 patients afferent to our outpatient clinic. INCLUSION CRITERIA: age >18 years, follow-up ≥5 years, estimated glomerular filtration rate (eGFR) <60mL/min/1.73 m(2), and/or diagnosed renal disease and/or presence of renal damage. Patients were divided into four groups according to their age: 25-55 years (n = 27), 56-65 (25), 66-75 (42), and 76-87 (22). eGFR was calculated using the modification of diet in renal disease and the CKD-epidemiology collaboration formulas. RESULTS: Younger patients had a significantly longer follow-up and less comorbidities, evaluated by the cumulative illness rating scale score, compared with the other groups. There was no difference between creatinine at baseline and at the end-of-follow-up period among the groups. Even though renal function significantly decreased in all groups, we noticed a slower progression as the age increased, and the difference between basal and end-of-follow-up eGFR was minimal in the group of patients aged 76-87 years. Analyzing the eGFR of every ambulatory control plotted against the year of follow-up, we showed a more rapid loss of filtrate in the younger group. Instead, loss of renal function decreased as the age of patients increased. CONCLUSIONS: This study demonstrates that, in elderly Italian participants, progression of CKD occurs more slowly than in younger patients. This implies that we may probably face an epidemic of CKD but that most of elderly patients diagnosed with CKD may not evolve to end-stage renal disease and require renal replacement therapy

design of dss for supporting preparedness to and management of anomalous situations in complex scenarios

Decision Support Systems (DSS) are complex technological tools, which enable an accurate and complete scenario awareness, by integrating data from both "external" (physical) situation and current behaviour and state of functioning of the technological systems. The aim is to produce a scenario analysis and to guess identify educated the most efficient strategies to cope with possible crises. In the domain of Critical Infrastructures (CI) Protection, DSS can be used to support strategy elaboration from CI operators, to improve emergency managers capabilities, to improve quality and efficiency of preparedness actions. For these reasons, the EU project CIPRNet, among others, has realised a new DSS designed to help operators to deal with the complex task of managing multi-sectorial CI crises, due to natural events, where many different CI might be involved, either directly or via cascading effects produced by (inter-)dependency mechanisms. This DSS, called CIPCast, is able to produce a real-time operational risk forecast of CI in a given area; other than usable in a real-time mode, CIPCast could also be used as scenario builder, by using event simulators enabling the simulation of synthetic events whose impacts on CI could be emulated. A major improvement of CIPCast is its capability of measuring societal consequences related to the unavailability of primary services such as those delivered by CI