7,641 research outputs found

    Poly(3-hydroxybutyrate)-ethyl cellulose based bio-composites with novel characteristics for infection free wound healing application

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    A series of bio-composites including poly3-hydroxybutyrate [P(3HB)] grafted ethyl cellulose (EC) stated as P(3HB)-EC were successfully synthesised. Furthermore, natural phenols e.g., p-4-hydroxybenzoic acid (HBA) and ferulic acid (FA) were grafted onto the newly developed P(3HB)-EC-based bio-composites under laccase-assisted environment without the use of additional initiators or crosslinking agents. The phenol grafted bio-composites were critically evaluated for their antibacterial and biocompatibility features as well as their degradability in soil. In particular, the results of the antibacterial evaluation for the newly developed bio-composites indicated that 20HBA-g-P(3HB)-EC and 15FA-g-P(3HB)-EC bio-composites exerted strong bactericidal and bacteriostatic activity against Gram- E. coli NTCT 10418 as compared to the Gram+ B. subtilis NCTC 3610. This study shows further that at various phenolic concentrations the newly synthesised bio-composites remained cytocompatible with human keratinocyte-like HaCaT skin cells, as 100% cell viability was recorded, in vitro. As for the degradation, an increase in the degradation rate was recorded during the soil burial analyses over a period of 42 days. These findings suggest that the reported bio-composites have great potential for use in wound healing; covering the affected skin area which may favour tissue repair over shorter periods

    Development of bio-composites with novel characteristics: Evaluation of phenol-induced antibacterial, biocompatible and biodegradable behaviours

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    This paper describes a laccase-assisted grafting of gallic acid (GA) and thymol (T) as functional entities onto the previously developed P(3HB)-g-EC composite. GA-g-P(3HB)-g-EC and T-g-P(3HB)-g-EC bio-composites were prepared by laccase-assisted free radical-induced graft polymerisation of GA and T onto the P(3HB)-g-EC based composite using surface dipping and incorporation technique. The results of the antibacterial evaluation for the prepared composites indicated that 15GA-g-P(3HB)-g-EC, 15T-g-P(3HB)-g-EC and 20T-g-P(3HB)-g-EC composites possessed the strongest bacteriostatic and bactericidal activities against Gram-positive B. subtilis NCTC 3610 and S. aureus NCTC 6571 and Gram-negative E. coli NTCT 10418 and P. aeruginosa NCTC 10662 strains. In this study, we have also tested GA-g-P(3HB)-g-EC and T-g-P(3HB)-g-EC bio-composites for their ability to support and maintain multilineage differentiation of human keratinocyte-like (HaCaT) skin cells in-vitro. From the cytotoxicity results, the tested composites showed 100% viability and did not induce any adverse effect on a HaCaT’s morphology. Finally, in soil burial evaluation, a progressive increase in the degradation rate of GA-g-P(3HB)-g-EC and T-g-P(3HB)-g-EC bio-composites was recorded with the passage of time up to 6 weeks. In summary, our current findings suggest that GA-g-P(3HB)-g-EC and T-g-P(3HB)-g-EC bio-composites are promising candidates for biomedical type applications such as skin regeneration, multiphasic tissue engineering and/or medical implants

    Teaching Data Literacy for Civic Engagement: Resources for Data Capture and Organization

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    Endangered Data Week emerged in the early months of 2017 as an effort to encourage conversations about government-produced, open data and the many factors that can limit its access. The event offers an internationally-coordinated series of events that includes publicizing the availability of datasets, increasing critical engagement with them, encouraging open data policies at all levels of government, and the fostering of data skills through workshops on curation, documentation and discovery, improved access, and preservation. The reflection provides an outline of the curriculum development happening through Endangered Data Week and encourages others to contribute

    Determining Optimal Levels of Nitrogen Fertilizer Using Random Parameter Models

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    The parameters of yield response functions can vary by year. Past studies usually assume yield functions are nstochastic ‘‘limited’’ stochastic. In this study, we estimate rye– ryegrass yield functions in which all parameters are random. The three functional forms considered are the linear response plateau, the quadratic, and the Spillman-Mitscherlich. Nonstochastic yield models are rejected in favor of stochastic parameter models. Quadratic functional forms fit the data poorly. Optimal nitrogen application recommendations are calculated for the linear response plateau and Spillman-Mitscherlich. The stochastic models lead to smaller recommended levels of nitrogen, but the economic benefits of using fully stochastic crop yield functions are small because expected profit functions are relatively flat for the stochastic yield functions. Stochastic crop yield functions provide a way of incorporating production, uncertainty into input decisions.cereal rye–ryegrass, Monte Carlo, nitrogen, random parameters, stochastic plateau, Production Economics, Q10, C12, D24,

    Determining Optimal Levels of Nitrogen Fertilizer Using Random Parameter Models

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    The parameters of yield response functions can vary by year. Past studies usually assume yield functions are nonstochastic or ‘limited’ stochastic. In this study, we estimate rye-ryegrass yield functions where all parameters are random. Optimal nitrogen rates are calculated for two yield response functions: linear response plateau and quadratic. Nonstochastic models are rejected in favor of stochastic parameter models. However, the economic benefits of using fully stochastic models are small since optimal nitrogen rates do not differ greatly between stochastic and nonstochastic models.Linear response plateau, Monte Carlo, nitrogen, random parameters, Agricultural and Food Policy, Crop Production/Industries, Farm Management, Production Economics,

    Development of novel antibacterial active, HaCaT biocompatible and biodegradable CA-g-P(3HB)-EC biocomposites with caffeic acid as a functional entity

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    International audienceWe have developed novel composites by grafting caffeic acid (CA) onto the P(3HB)-EC based material and laccase from Trametes versicolor was used for grafting purposes. The resulting composites were designated as CA-g-P(3HB)EC i.e., P(3HB)-EC (control), 5CA-g-P(3HB)-EC, 10CA-g-P(3HB)-EC, 15CA-g-P(3HB)-EC and 20CA-g-P(3HB)-EC. FT-IR (Fourier-transform infrared spectroscopy) was used to examine the functional and elemental groups of the control and laccase-assisted graft composites. Evidently, 15CA-g-P(3HB)-EC composite exhibited resilient antibacterial activity against Gram-positive and Gram-negative bacterial strains. Moreover, a significant level of biocompatibility and biodegradability of the CA-g-P(3HB)-EC composites was also achieved with the human keratinocytes-like HaCaT cells and soil burial evaluation, respectively. In conclusion, the newly developed novel composites with multi characteristics could well represent the new wave of biomaterials for medical applications, and more specifically have promising future in the infection free would dressings, burn and/or skin regeneration field due to their sophisticated characteristics

    The Role of Relapse Prevention and Goal Setting in Training Transfer Enhancement

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    This article reviews the effect of two post-training transfer interventions (relapse prevention [RP] and goal setting [GS]) on trainees’ ability to apply skills gained in a training context to the workplace. Through a review of post-training transfer interventions literature, the article identifies a number of key issues that remain unresolved or underexplored, for example, the inconsistent results on the impact of RP on transfer of training, the lack of agreement on which GS types are more efficient to improve transfer performance, the lack of clarity about the distinction between RP and GS, and the underlying process through which these two post-training transfer interventions influence transfer of training. We offer some recommendations to overcome these problems and also provide guidance for future research on transfer of training

    An examination of the most effective instructional method that disseminates content, context and process of the athletic training profession to its members through continuing professional education activities

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    Continuing education requirements in all fields and professions are intended to promote continued competence, to develop current knowledge and skills, and to enhance professional skills and judgment beyond the levels required for entry-level practice. The idea of enhancing one’s knowledge and the ability to stay current with the newest updates in one’s profession is vital to the success of an individual and his/her profession. The profession of athletic training is no different. Being a part of the allied health field, the profession of athletic training continues to evolve. All professionals continue their education through experiences, formal schooling or continuing education systems. How can continuing professional education be most effective in enhancing the certified athletic trainer (ATC) in the ever evolving allied health field? The purpose of the study was to examine and then determine the most preferred method of continuing professional education (CPE) for certified athletic trainers (ATC). The research study evaluates the most effective instructional method to disseminate the content, context and the process of the athletic training profession to its members through continuing education activities. Continuing education requirements are intended to promote continued competence, development of current knowledge and skills, and enhancement of professional skills and judgment beyond the levels required for entry-level practice. The governing body of the National Athletic Trainers’ Association (NATA) requires its members to participate in continuing education activities for these reasons. The study involved 287 certified athletic trainers (ATC) and their responses through a survey instrument. The survey instrument was sent to every certified athletic trainer in Indiana through the Internet and their responses were collected by Ball State University’s Research Design and Analysis Services. The ATCs responded to a multitude of questions concerning their view of continuing education, impediments to continuing education and their demographics. After reviewing the data, certified athletic trainers responses resulted in showing a strong preference to hands-on and interactive opportunities as being the best perceived delivery system to provide the profession and its members with continuing education experiences.Department of Educational LeadershipThesis (D. Ed.
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