5 research outputs found
Omecamtiv mecarbil in chronic heart failure with reduced ejection fraction, GALACTICâHF: baseline characteristics and comparison with contemporary clinical trials
- Author
- Aaronson Keith
- Abadier Rafik
- Abbasi Siddique A.
- Abdullah Shuaib
- Abelson Mark
- Abhayaratna Walter
- Ablasser Klemens
- Aboyans Victor
- AboâAuda Wael
- Abuannadi Mohammad
- Adams Kirkwood
- Adams Kirkwood F.
- Adhya Shaumik
- Adler Alexander
- Aggarwala Gaurav
- Agostoni Piergiuseppe
- Ahmad Saad
- Aiub Jorge Roberto
- Al Mohammad Abdallah
- Alharethi Rami
- Alieksieieva Liudmyla
- Almeida Filipa
- Almousalli Omar
- Amano Tetsuya
- Amanullah Aman
- Ambardekar Amrut
- Amerena John
- Anand Inder
- Anderson William
- Ando Kenji
- Andreka Peter
- Antalik Lubomir
- Aradi Daniel
- Araiza Raul Reyes
- Arbolishvili Georgy
- Ariani Mehrdad
- AriasâMendoza Alexandra
- Arora Raveen
- Arroyo Julian Alonso Coronel
- Artis Andre
- Asakura Masanori
- Asano Hiroshi
- Ashcom Thomas
- Aslam Shamaila
- Asubiaro Joshua
- Atherton John
- Avaca Horacio Alberto
- Babapulle Mohan
- Bacal Fernando
- Badak Ozer
- Badariene Jolita
- Badat Aysha
- Baker Mathue
- Balsam Pawel
- Banerji Sourin
- Barbarash Olga
- Barbetseas Ioannis
- Barr Craig
- Barros e Silva Pedro Gabriel Melo
- Barua Rajat
- Bauerlein Eugene Joseph
- Baweja Paramdeep
- Bednarkiewicz Zbigniew
- Beelen Driek
- Begg Alistair
- Bekar Lutfu
- Belenkiy Dmitriy
- Belohlavek Jan
- Beltrame John
- Berdague Philippe
- Berglund Stefan
- Berk Martin
- Berkowski Piotr
- Berra Fernando Colombo
- Bertolet Barry
- Besada Diego Alejandro
- Beug Daniel
- Bezzegh Katalin
- Bhagwat Ravi
- Bhargava Rakesh
- BieringâSĂžrensen Tor
- Bilato Claudio
- Blicharski Tomasz
- Boccalandro Fernando
- Boehm Michael
- Boehmer John
- Bogaev Roberta
- Bolshakova Olga
- Boman Kurt
- Bonderman Diana
- Bonet Luis Almenar
- Bonfanti Alberto Cadena
- Bordonava Anselmo Paulino
- Bostick Brian
- Boswijk Dirk
- Bourgeois Ronald
- Bourhaial Hakima
- Bouza Manuel
- Braga Joao Carlos
- Brasca Daniela Garcia
- Brinkley Douglas
- Brito Dulce
- Brunetti Natale Daniele
- Bruno Marco Raul Litvak
- Bu Peili
- Burgess Lesley
- Busak Ladislav
- Buynak Robert
- Buysschaert Ian
- Bykov Alexander
- Böhm Michael
- Caccavo Alberto
- Canesin Manoel
- Cardona Jose
- Cardoso Juliano
- Carluccio Erberto
- Carrasco Jose Alfredo Pagola
- Carson Peter
- Castillo Armando Garcia
- Cavallini Claudio
- Cavusoglu Yuksel
- Cech Vladimir
- Celik Ahmet
- Celutkiene Jelena
- Cepelak Michal
- Cerci Rodrigo Julio
- Chandra Lokesh
- Chandrasekaran Badrinathan
- Chang David
- Chaves Renato
- Chehayeb Raja
- Cheirif Jorge
- Chen Guoqin
- Chen Jiyan
- Chmielak Zbigniew
- Chouchane Iman
- Chung Eugene
- Cid Maria Cristina Schnettler
- Civitello Andrew
- Clark Andrew
- Cleland John G.F.
- Clifford Piers
- Coletti Andrew
- Collins John
- Colque Roberto
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- Contreras Johanna
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- Corbalan Ramon
- Correa Luis Eduardo Echeverria
- Corredor Miguel Alfredo Moncada
- Cosansu Kahraman
- CostaâVitali Atilio
- Cotarlan Vladimir
- Coufal Zdenek
- Cox Jeremy
- CrespoâLeiro Maria G.
- Cruz Kimberly
- Cubero Javier Segovia
- Cui Hanbin
- Cymerman Krzysztof
- Dahlström Ulf
- Damy Thibaud
- Dauber Ira
- De Geeter Guillaume
- De los Rios Ibarra Manuel Odin
- De Pasquale Carmine
- Decoulx Eric
- Demir Mesut
- Desai Pratik
- Diaz Rafael
- Diaz Rafael
- Diaz Victor Alfonso Jimenez
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- Diez Mirta
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- Doblas Juan Jose Gomez
- Doi Masayuki
- Domae Hiroshi
- Donal Erwan
- Dong Yugang
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- Dorobantu Maria
- Dovgolis Svetlana
- Doyle Timothy
- Drexel Heinz
- Dronov Dmitry
- Droogne Walter
- Drozdz Jaroslaw
- Duarte Tatiana
- Duengen HansâDirk
- Dujardin Karl
- Dupont Matthias
- Duran Ruben Omar Garcia
- Duzenli Mehmet
- Dzupina Andrej
- Eaton Charles
- Ebato Mio
- Ebelt Henning
- Eberly Arthur
- Ebner Christian
- Echeverria Correa Luis E.
- Elliott James
- Elmahi Einas
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- Fang James C.
- Farris Neil
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- Fu Xin
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- Vandekerckhove Hans
- Vanhecke Thomas
- Varin Claire
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- Vasilev Ivaylo
- Vasilyeva Larysa
- Vaz Garth
- Vazquez Eduardo Salcido
- Vega Mario
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- Venegas Manuel Eduardo Rodriguez
- Videbaek Lars
- Vidotti Maria Helena
- Vijay Nampalli
- Vilamajo Oscar Alberto Gomez
- Vilchez Francisco Gonzalez
- Villani Giovanni Quinto
- Villoch Mario
- Villota Julio Eduardo Nuñez
- Vinanska Daniela
- Vincenzi Antonella
- Vinereanu Dragos
- Vinereanu Dragos
- Vishnevsky Alexander
- Voevoda Mikhail
- Vogel Daniel
- Voicu OlgaâCristina
- Volterrani Maurizio
- Voors Adriaan
- Voors Adriaan A.
- Voronkov Leonid
- Vraa Soren
- Wada Atsuyuki
- Wahid Faisal
- Wal Ruud
- Wang Yi
- Wang Zhifang
- Watanabe Naoki
- Wei Yu
- Weir Robin
- Westenfeld Ralf
- Wheeler Matthew
- Whellan David
- Wiggers Henrik
- Wilkett Matt
- Willems Frank
- Williams Celeste
- Wlodarczyk Aleksander
- Wodlin Peter
- Wong Kenneth
- WozakowskaâKaplon Beata
- Wu Weiheng
- Yagensky Andriy
- Yamamoto Mitsutaka
- Yan Jing
- Yang Ping
- Yang Xuming
- Yang Zhenyu
- Yeoman Gary
- Yigit Zerrin
- Yilmaz Mehmet B.
- Yoshida Takeshi
- Yoshikawa Masaki
- Yousuf Kabir
- Yuan Zuyi
- Yuge Masaru
- Zabowka Maciej
- Zaca Valerio
- Zaidman Cesar
- Zanetti Fernando Tomas Lanas
- Zannad Faiez
- Zapata Gerardo
- Zdrenghea Dumitru
- Zeman Kamil
- Zeymer Uwe
- Zhang Jinguo
- Zhang Lily
- Zhang Shouyan
- Zhang Xuelian
- Zhang Yuhui
- Zhang Yuqing
- Zheng Yang
- Zheng Zhe
- Zhou Changyong
- Zieroth Shelley
- Zilahi Zsolt
- Zimmet Hendrik
- Zolty Ronald
- Zrazhevskiy Konstantin
- Zwaan Coenraad
- Publication venue
- 'Wiley'
- Publication date
- 01/11/2020
- Field of study
Aims:
The safety and efficacy of the novel selective cardiac myosin activator, omecamtiv mecarbil, in patients with heart failure with reduced ejection fraction (HFrEF) is tested in the Global Approach to Lowering Adverse Cardiac outcomes Through Improving Contractility in Heart Failure (GALACTICâHF) trial. Here we describe the baseline characteristics of participants in GALACTICâHF and how these compare with other contemporary trials.
Methods and Results:
Adults with established HFrEF, New York Heart Association functional class (NYHA)ââ„âII, EF â€35%, elevated natriuretic peptides and either current hospitalization for HF or history of hospitalization/ emergency department visit for HF within a year were randomized to either placebo or omecamtiv mecarbil (pharmacokineticâguided dosing: 25, 37.5 or 50âmg bid). 8256 patients [male (79%), nonâwhite (22%), mean age 65âyears] were enrolled with a mean EF 27%, ischemic etiology in 54%, NYHA II 53% and III/IV 47%, and median NTâproBNP 1971âpg/mL. HF therapies at baseline were among the most effectively employed in contemporary HF trials. GALACTICâHF randomized patients representative of recent HF registries and trials with substantial numbers of patients also having characteristics understudied in previous trials including more from North America (n = 1386), enrolled as inpatients (n = 2084), systolic blood pressureâ<â100âmmHg (n = 1127), estimated glomerular filtration rate <â30âmL/min/1.73 m2 (n = 528), and treated with sacubitrilâvalsartan at baseline (n = 1594).
Conclusions:
GALACTICâHF enrolled a wellâtreated, highârisk population from both inpatient and outpatient settings, which will provide a definitive evaluation of the efficacy and safety of this novel therapy, as well as informing its potential future implementation
A Saude da Infancia ou conselhos as mães sobre a conservação dos filhos durante os ultimos tempos de prenhez e sua educação physica no primeiro periodo da vida commum
- Author
- Publication venue
- Porto : Typographia de JosĂ© Pereira da Silva & FÂș
- Publication date
- 01/01/1865
- Field of study
A criança e o seu desenvolvimento em discursos mĂ©dicos e pedagĂłgicos que circularam no contexto portuguĂȘs (sĂ©culos XVIII a XX)
- Author
- ABREU José Rodrigues de
- ALMEIDA Francisco José de
- AntĂłnio Gomes Ferreira
- ARIĂS Philippe
- BECCHI Egle
- BECCHI Egle
- BECQUEREL A.
- BEE H.
- BIAGGIO A.B.
- BOTO Carlota
- CARVALHO Francisco da Silva
- CASTRO Luiz de Barros de Faria e
- CHASSAGNE Serge
- CHAVES Armando
- COMĂNIO JoĂŁo AmĂłs
- COMĂNIO JoĂŁo AmĂłs
- CRUZ Emygio Pereira
- FERREIRA AntĂłnio Gomes
- FERREIRA AntĂłnio Gomes
- FERREIRA AntĂłnio Gomes
- FRANCO Francisco de Melo
- FREIRE Antonio José Pimenta
- GAUPP Robert
- GONDRA José G
- GOUV A
- LEITĂO Manuel da Silva
- LEITĂO Manuel JosĂ©
- LEMOS Maximiano
- LIMA Antonio Martins de Souza
- LIMA Manoel Carvalho d'Araujo
- LOBO Alfredo Duarte
- LUC Jean-Noël
- MARTINS Ălvaro
- MOULY G.J.
- MUSSEN P.H.
- MUSSEN P.H.
- PAIVA Manuel Joaquim Henriques de
- PARRA Francisco Ignacio
- PIMENTEL FILHO Alberto
- PROENĂA AntĂłnio Augusto
- RIBEIRO Guilherme Urbano da Costa
- ROSA M.
- SANTOS Alves
- SARMENTO Aurélia de Moraes
- SAWREY J.M.
- THONG TRAN
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
Make EU trade with Brazil sustainable
- Author
- Aalders Inge
- Aavik Tsipe
- Addison Prue
- af Segerstad Louise Hard
- Aguilee Robin
- Aguilera Eduardo
- Albanito Fabrizio
- Alexanderson Helena
- Alonso Juan C.
- Alonso-Alvarez Carlos
- Altringham John
- Alvarez Matheus Rodriguez
- Ammer Christian
- Amo Luisa
- Andresen Louise C.
- Ange Olivia
- Antal Miklos
- Antonelli Alexandre
- Antwis Rachael
- Aragon Pedro
- Arlidge William
- Arlt Debora
- Ascensao Fernando
- Ascoli Davide
- Bacon Christine D.
- Bager Simon L.
- Bagneres Anne-Genevieve
- Balmford Andrew
- Balmford Andrew
- Banks-Leite Cristina
- Barlow Jos
- Barrientos Rafael
- Bastos Araujo Miguel
- Batsleer Femke
- Battisti Corrado
- Battiston Roberto
- Bauer Barbara
- Baumann Matthias
- Benavides Lucia
- Bennett Dominic J.
- Benyei Petra
- Berenguer Erika
- Bernardo-Madrid Ruben
- Bhan Manan
- Biedermann Peter
- Billen Gilles
- Bjoersne Anna-Karin
- Bjorck Svante
- Bjorklund Heidi
- Blanco Moreno Jose M.
- Bleyhl Benjamin
- Bocquillon Pierre
- Boehnert Tim
- Bongalov Boris
- Boonstra Wiebren
- Booth Hollie
- Borges Paulo A. V.
- Borregaard Michael Krabbe
- Borrell Asuncion
- Boto Luis
- Brambach Fabian
- Briens Francois
- Brown Calum
- Brumelis Guntis
- Bruna Josef
- Buckley David
- Buckley Yvonne
- Buzzetti Filippo Maria
- Cabello Javier
- Cabeza Mar
- Cabral Juliano Sarmento
- Cahen-Fourot Louison
- Caillon Sophie
- Canals Oriol
- Canteri Elisabetta
- Caprio Enrico
- Cardoso Pedro
- Carmenta Rachel
- Carnicer Jofre
- Carrillo Juan D.
- Carvalho Joana
- Casazza Marco
- Cassar Louis F.
- Cathy Vet Gibault
- Cattaneo Claudio
- Celine Bellard
- Cesarz Simone
- Challender Dan
- Chenet Hugues
- Chobanov Dragan Petrov
- Christie Alec Philip
- Christophe Piquet Julien
- Chuine Isabelle
- Chvatalova Veronika
- Clark Mike
- Coenen Johanna
- Colino Rabanal Victor
- Collalti Alessio
- Comandulli Carolina
- Conde Marta
- Conrad Elisabeth
- Cooke Sophia
- Cooper Conor
- Corbera Esteve
- Cordero Ana Maria Araujo
- Cornell Sarah
- Cotta Benedetta
- Cottyn Hanne
- Crona Beatrice
- Csergo Anna Maria
- Curtis David
- D'Amico Marcello
- da Fonte Luis Fernando Marin
- da Silva Jessica Fonseca
- da Silva Sven
- Danet Alain
- Daniel-Ferreira Juliana
- Dara Andrey
- Darras Kevin
- Dauriach Alice
- Davoli Marco
- Daw Tim
- de Agua Luis Borda
- de Castro Fabio
- de Castro Paula Drummond
- de Freitas Flavio Luiz Mazzaro
- de Frutos Angel
- De Knijf Geert
- de la Pena Eduardo
- De la Riva Ignacio
- De Marzo Teresa
- De Smedt Pallieter
- De Smedt Sebastian
- de Waroux Yann le Polain
- Deguines Nicolas
- Dengler Juergen
- Di Gregorio Monica
- Diaz Mario
- Doherty Anya
- Domingos Tiago
- Duran Paz
- Durieux Laurent
- Edler Daniel
- Eiro Flavio
- Eisenhauer Nico
- Elias Marianne
- Emperaire Laure
- Engel Thore
- Engert Manuela
- Engl Tobias
- Engler Jan Oliver
- Englund Oskar
- Enqvist Johan
- Enseroth Tanja
- Erb Karlheinz
- Eriksson K. Martin
- Ernst Stefan
- Escobar Neus
- Esculier Fabien
- Essl Franz
- Evans Amy Louise
- Faberova Tamara
- Fandos Guillermo
- Fargallo Juan A.
- Farrell Katharine N.
- Felipe-Lucia Maria
- Felix Rob
- Fernandez-Llamazares Alvaro
- Figueiredo Ludmilla
- Fischer Joern
- Fischer-Kowalski Marina
- Fitton Nuala
- Fleischer Katrin
- Florencio Margarita
- Florez Laura V.
- Fraixedas Sara
- Franco Aldina
- Frantz David
- Friis Cecilie
- Frossard Carolina M.
- Fuchs Richard
- Gambin Belinda
- Garcia del Amo David
- Garcia Maria Mancilla
- Garnett Emma
- Garnett Tara
- Garnier Josette
- Gebara Maria Fernanda
- Geldmann Jonas
- Gerlach Justin
- Geschke Jonas
- Ghazoul Jaboury
- Gherghel Iulian
- Ghoddousi Arash
- Gil Diego
- Gledhill John
- Godde Cecile
- Goepel Jan
- Goerg Christoph
- Golland Ami
- Gollnow Florian
- Gomes Carmen Bessa
- Gonzalez Adriana Trompetero
- Goula Marta
- Granda Elena
- Grass Ingo
- Greenfield Michael
- Gremillet David
- Grieco Elisa
- Grilo Clara
- Gruychev Gradimir Valentinov
- Guedes Thais
- Gueldner Dino
- Guerrero Mayra Daniela Pena
- Guth Miriam Karen
- Haberl Helmut
- Hacket-Pain Andrew
- Hadjichambis Andreas
- Hahn Thomas
- Haklay Muki
- Hankerson Brett
- Heikkinen Anna
- Heikkurinen Pasi
- Heinen Julia Helena
- Heller Klaus-Gerhard
- Helm Aveliina
- Henders Sabine
- Henriksson Patrik J. G.
- Henrique Faria Sergio
- Henriques Sergio
- Hernandez Miguel
- Heylen Brigitte
- Hide Geoff
- Hinsley Amy
- Hinton Jennifer
- Hissa Leticia B. V.
- Hochkirch Axel
- Holzschuh Andrea
- Hortal Joaquin
- Hosner Peter A.
- Hurtado Fernando
- Infante-Amate Juan
- Islar Mine
- Ivkovic Slobodan
- Jacobs Sander
- Janke Rebekka
- Jarcuska Benjamin
- Johanisova Nadia
- Johansson Maria
- Johnson Mark D.
- Jones Julia Patricia Gordon
- Jucker Tommaso
- Juergensen Jonathan
- Jung Martin
- Junginger Martin
- Kallis Giorgos
- Kaltenpoth Martin
- Kanka Robert
- Karagouni Niki
- Kasimir Asa
- Kastner Thomas
- Kati Vassiliki
- Kechev Mihail Ognianov
- Kehoe Laura
- Kehoe Laura
- Keil Petr
- Keller Alexander
- Kerner Janika
- Kessner-Beierlein Daniela
- Kipson Marina
- Knohl Alexander
- Koh Niak
- Koster Martijn
- Kovar Pavel
- Krause Torsten
- Kreft Holger
- Kristin Anton
- Krofel Miha
- Krueger Tobias
- Kuemmerle Tobias
- Kuemmerle Tobias
- Kurdikova Vendula
- Langerwisch Fanny
- Lapka Miloslav
- Larson Sven Ake
- Lassaletta Luis
- Latella Leonardo
- Lavorel Sandra
- Lehikoinen Aleksi
- Leidinger Ludwig
- Leijten Floris
- Leitao Pedro J.
- Lena Philippe
- Lens Luc
- Leonhardt Sara Diana
- Leroy Boris
- Leve Marine
- Levers Christian
- Lewerentz Anne
- Lewis Jerome
- Libbrecht Romain
- Lindkvist Emilie
- Lipsky Zdenek
- Ljubomirov Toshko
- Llusia Diego
- Lobmann Michael
- Lobo Jorge M.
- Loetters Stefan
- Londo Marc
- Lopez Baucells Adria
- Lopez Bosch David
- Lopez Hernandez Heriberto D.
- Lopez-Marquez Violeta
- Lorrilliere Romain
- Louis Deharveng
- Lukic Marko
- Lutter Stephan
- Macdiarmid Jennie
- Mace Georgina
- Machordom Annie
- Macia Manuel J.
- Mairota Paola
- Malecore Eva
- Marescaux Audrey
- Marselle Melissa
- Martin Arnaud
- Martin Jean-Louis
- Martin Philip
- Martins Andrea Damacena
- Marull Joan
- Mas Navarro Maria
- Mascarenhas Andre
- Massa Bruno
- Masterson Vanessa Anne
- Matenaar Daniela
- Mateos David Moreno
- Matos-Maravi Pavel
- Maurel Noelie
- Mayer Andreas
- Mayer Martin
- McKay David Armstrong
- Mckeon Caroline
- McPhearson Timon
- Medvedovic Jasna
- Mehrabi Zia
- Mempel Finn
- Menzel Florian
- Mertz Ole
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- Meyer Carsten
- Meyer Christoph
- Meyfroidt Patrick
- Milchev Boyan Petrov
- Monserand Antoine
- Montade Vincent
- Morales Manuel B.
- Moreira Francisco
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- Moreta Lys Sanz
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- Motivans Elena
- Motta Renzo
- Moyano Fernando Esteban
- Mueller Daniel
- Mueller Joerg
- Mumby Hannah S.
- Munteanu Catalina
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- Mutke Jens
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- Novoa Ana
- Nuernberger Fabian
- Nuissl Henning
- Nunes Matheus Henrique
- Nygren Michelle
- Ochu Erinma
- Oddie Melissa
- Ohrling Christian
- Oliveira Eduardo
- Olsson Gunilla Almered
- Olsson Urban
- Oppel Steffen
- Orach Kirill
- Orland Chloe
- Ostapowicz Katarzyna
- Ostermann Ole
- Oyanedel Rodrigo
- Padro Caminal Roc
- Paitan Claudia Parra
- Palm Celinda
- Palmeirim Jorge
- Panferov Oleg
- Partel Meelis
- Pascual Unai
- Pe'er Guy
- Peco Begona
- Pedersen Anna Frohn
- Pendrill Florence
- Penone Caterina
- Pereira Laura
- Peres Carlos A.
- Perez-Ortega Sergio
- Pergl Jan
- Perrigo Allison
- Persson Joel
- Persson Martin
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- Peterson Gustaf
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- Petrik Petr
- Petrovan Silviu
- Petter Gunnar
- Phalan Ben
- Pichler Melanie
- Piemontese Luigi
- Pienkowski Thomas
- Pilo Francesca
- Piotrowski Jan A.
- Piquer-Rodriguez Maria
- Polaina Ester
- Pollet Marc
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- Presa Asencio Juan Jose
- Prevel Leonie
- Prince Karine
- Pucetaite Milda
- Pueyo Salvador
- Pynegar Edwin L.
- Pysek Petr
- Qin Siyu
- Rammig Anja
- Rands Mike
- Razanajatovo Mialy
- Rebelo Hugo
- Redlich Sarah
- Reis Tiago
- Renaud Pierre-Cyril
- Revilla Eloy
- Reyes-Garcia Victoria
- Rhee Howon
- Richardson Vanessa A.
- Riede Klaus
- Riggi Laura
- Rilovic Andro
- Ringsmuth Andrew
- Ritter Camila Duarte
- Robillard Tony
- Rocha Juan Carlos
- Rocha Ricardo
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- Rodriguez-Labajos Beatriz
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- Romero-Munoz Alfredo
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- Rothhaupt Karl-Otto
- Roturier Samuel
- Rounsevell Mark
- Roux Nicolas
- Rozylowicz Laurentiu
- Ruedenauer Fabian
- Rufin Philippe
- Rugani Benedetto
- Rust Niki
- Rutschmann Benjamin
- Rutting Tobias
- Salaseviciene Alvija
- Salek Martin
- Sanchez-Fernandez David
- Santagata Remo
- Santos Ana M. C.
- Sanz-Cobena Alberto
- Savaget Paulo
- Sayol Ferran
- Schilthuizen Menno
- Schindler Stefan
- Schleicher Judith
- Schlerf Martin
- Schmelzer Stefan
- Schmoll Tim
- Schneider Christoph
- Schnitzler Jan
- Schroeder Heike
- Schuenzel Julia
- Schug Franz
- Schumacher Kim
- Schwieder Marcel
- Seebens Hanno
- Sekerka Lukas
- Selva Nuria
- Semper-Pascual Asuncion
- Seppelt Ralf
- Seufert Verena
- Sieger Charlotte Sophie
- Silvestro Daniele
- Simaika John P.
- Simon Judy
- Sinare Hanna
- Sindicic Magda
- Singh Chandrakant
- Sjoberg Sissel
- Skejo Josip
- Smetschka Barbara
- Smith Annabel
- Smith Pete
- Smith Rebecca
- Snell Katherine
- Sober Virve
- Somma Francesca
- Souza Queiroz Allan
- Sovova Lucie
- Sperfeld Erik
- Staal Arie
- Stajerova Katerina
- Stanek Nicola
- Staude Ingmar
- Stein Anke
- Steinberger Julia K.
- Stenseke Marie
- Stibral Karel
- Strubbe Diederik
- Strugariu Alexandru
- Suarez Manuela Gonzalez
- Sullivan Martin
- Sutherland William J.
- Swinfield Tom
- Taiti Stefano
- Tatin Laurent
- Taylor Astrid
- Tello Enric
- Tengo Maria
- Teplitsky Celine
- Theurl Michaela C.
- Thieu Vincent
- Thonicke Kirsten
- Tiralla Nina
- Toledo-Hernandez Manuel
- Torre Ignasi
- Torres Aurora
- Traba Diaz Juan
- Trogisch Stefan
- Truong Minh-Xuan A.
- Tscharntke Teja
- Uddling Johan
- Ulgiati Sergio
- Vacchiano Giorgio
- Vaclavik Tomas
- Vajda Vivi
- Valdecasas Antonio G.
- Valentini Riccardo
- Valladares Fernando
- van den Burg Matthijs P.
- van der Ent Ruud J.
- van der Linden Sebastian
- van Kleunen Mark
- Vasconcelos Sasha
- Vavra Jan
- Verburg Peter
- Vieites David
- Vighi Morgana
- Vila Traver Jaime
- Villen-Perez Sara
- Vira Bhaskar
- Virah-Sawmy Malika
- Vlahos George
- Voigt Christian C.
- Voigt Maria
- Volaire Florence
- von Doehren Peer
- Wagner Norman
- Wandl Marie-Theres
- Wang-Erlandsson Lan
- Wanger Thomas Cherico
- Wassen M. J.
- Weigelt Patrick
- Weigend Maximilian
- Whittaker Robert J.
- Wiegand Kerstin
- Wieringa Jan J.
- Willemse Luc
- Winiwarter Verena
- Winter Marten
- Wong Grace
- Wordley Claire
- Worthington Thomas
- Yates Katherine
- Yin Fang
- Zafra-Calvo Noelia
- Zang Christian
- Zemp Delphine Clara
- Zhang Zhijie
- Zirion Maria
- Zobel Martin
- zu Ermgassen Erasmus
- Zucaro A.
- Zurell Damaris
- Publication venue
- 'American Association for the Advancement of Science (AAAS)'
- Publication date
- 01/01/2019
- Field of study
Brazil, home to one of the planet's last great forests, is currently in trade negotiations with its second largest trading partner, the European Union (EU). We urge the EU to seize this critical opportunity to ensure that Brazil protects human rights and the environment
Cardiac myosin activation with omecamtiv mecarbil in systolic heart failure
- Author
- A Alan Chu
- A Shekhar Pandey
- Aaron Sverdlov
- Abbasi S. A.
- Abdallah Al Mohammad
- Abdul Al-Hesayen
- Adams K. F.
- Adnan Malik
- Adriaan Voors
- Adrian Shandling
- Agata Marina Floresta
- Ahmet Celik
- Ailiman Mahemuti
- Aize van der Sluis
- Akihiro Koike
- Akihiro Nakamura
- Akihiro Terasawa
- Alan Gass
- Alan Kono
- Alan Meholick
- Alberto Caccavo
- Alberto Cadena Bonfanti
- Alberto Esteban Bazzoni Ruiz
- Alberto Fernandez
- Alberto Margonato
- Aldo Prado
- Alejandro Recio Mayoral
- Aleksander Wlodarczyk
- Aleksandra Manolova
- Alessandro Fucili
- Alex Mauricio Villablanca Sepulveda
- Alexander Adler
- Alexander Bykov
- Alexander Parkhomenko
- Alexander Sherenkov
- Alexander Timofeev
- Alexander Vishnevsky
- Alexandr Schee
- Alexandra Arias Mendoza
- Alexandre Tognon
- Alexey Repin
- Alicia Contreras Rodriguez
- Alina Giuca
- Alisdair Ryding
- Alistair Begg
- Almir Ferraz
- Alonzo Jones
- Amal Muthumala
- Aman Amanullah
- Amarinder Bindra
- Amin Karim
- Amin Yehya
- Amit Shah
- Amrut Ambardekar
- Ana Maria De Leon Flores
- Anand I.
- Anays Santana Izquierdo
- Andras Papp
- Andre Artis
- Andrea Mortara
- Andrej Dzupina
- Andres Iñiguez Romo
- Andrew Boyle
- Andrew Civitello
- Andrew Clark
- Andrew Coletti
- Andrew Hamilton
- Andrew Ludman
- Andrew Sauer
- Andrew Sindone
- Andriy Yagensky
- Andrzej Rynkiewicz
- Aniko Papp
- Anil Shah
- Anna Paszczuk
- Anna Stankiewicz
- Anselmo Paulino Bordonava
- Anthony Gemignani
- Anthony King
- Antonella Vincenzi
- Antonio Juan Castro Fernandez
- Antonio Lara Padron
- Apostolos Karavidas
- Arias-Mendoza A.
- Arif Elvan
- Arman Postadzhiyan
- Armando Garcia Castillo
- Arnold Seto
- Arthur Eberly 3rd
- Arun Krishnamoorthy
- Arunima Misra
- Assad Mouhaffel
- Assen Goudev
- Athanasios Manolis
- Atilio Costa-Vitali
- Atsushi Hirayama
- Atsutoshi Takagi
- Atsuyuki Wada
- Attila Mohacsi
- Aurelio Ortiz
- Aysha Badat
- Badrinathan Chandrasekaran
- Balgit Chhokar
- Barbara Pisani
- Barna Szabo
- Barry Bertolet
- Barry H Greenberg
- Barry Uretsky
- Batlagundu Lakshminarayanan
- Beat Knusel
- Beata Wozakowska-Kaplon
- Beatriz Diaz Molina
- Bela Herczeg
- Bela Merkely
- Benjamin Trichon
- Bhola Rama
- Biering-Sorensen T.
- Binoy Skaria
- Binu Jacob
- Bohm M.
- Bojidar Dimov
- Bonderman D.
- Boris Goloshchekin
- Bozena Sobkowicz
- Brack Hattler
- Bradley Weinberg
- Brenda Lemus
- Brenda Peart
- Brian Bostick
- Brian Claggett
- Brian Gordon
- Brian Houston
- Bruce Jackson
- Bruce Sussex
- Bruno Paolino
- Candida Fonseca
- Carl-Johan Lindholm
- Carlo Gabriele Tocchetti
- Carlos Alberto Luengas
- Carlos Arrieta Garcia
- Carlos Conejeros Kindel
- Carlos Poy
- Carmine De Pasquale
- Carol Davila
- Carsten Schmalfuss
- Celeste Williams
- Cesar Zaidman
- Cevat Kirma
- CezarEugen Macarie
- Changyong Zhou
- Charles Eaton
- Charles Koo
- Charles Lovell
- Charles Treasure
- Chavdar Velikov
- Chester Hedgepeth
- Chiara Melloni
- Chim Lang
- Christian Constance
- Christian Ebner
- Christian Mueller
- Christian Paolo Pincetti Jofre
- Christoph Kadel
- Christopher E Kurtz
- Christopher Judkins
- Christopher Lang
- Christopher Pickett
- Christopher Rowan
- Christopher Vaccari
- Christos Kassiotis
- Ciro Indolfi
- Claire Varin
- Clara Ines Saldarriaga Giraldo
- Claudia Raineri
- Claudio Bilato
- Claudio Cavallini
- Claudio Rodolfo Majul
- Cleland J. G. F.
- Coenraad van der Zwaan
- Constantin Militaru
- Corbalan R.
- Craig Barr
- Craig Hametz
- Crespo-Leiro M. G.
- Cristian Gheorghe Podoleanu
- Cristiano Pederneiras Jaeger
- Cristina Danila
- Csaba Salamon
- Dahlstrom U.
- Dalia Jarasuniene
- Dallas Price
- Dalton McLean
- Daniel Aradi
- Daniel Beug
- Daniel Fisher
- Daniel Gaudet
- Daniel Lenihan
- Daniel Lighezan
- Daniel Pauly
- Daniel Savard
- Daniel Vogel
- Daniela Garcia Brasca
- Daniela Pini
- Daniela Vinanska
- Dariusz Korczyk
- David Chang
- David F Kong
- David Henderson
- David Lanfear
- David Murray
- David Rawitscher
- David Schultz
- David Stepek
- David Whellan
- Debashis Roy
- Deddo Moertl
- Denis-Carl Phaneuf
- Dennis Rupka
- Deovrat Singh
- Devesh Patel
- Diana Bonderman
- Diaz R.
- Diego Alejandro Besada
- Diego Felipe Martinez
- Dimitrios Tziakas
- Dinesh Gupta
- Dipti Itchhaporia
- Dirk Boswijk
- Dirk Lok
- Dirk Schellings
- Dmitriy Belenkiy
- Dmitry Dronov
- Dmytro Reshotko
- Domenico Bonaduce
- Domingo Andres Pascual Figal
- Dongye Li
- Donna Mancini
- Dora Ines Molina de Salazar
- Douglas Brinkley
- Douglas Martel
- Douglas Sawyer
- Dragos Vinereanu
- Driek Beelen
- Dulce Brito
- Dumitru Zdrenghea
- Echeverria L. E.
- Edmundo Alfredo Bayram Llamas
- Edo Kaluski
- Eduardo Perna
- Eduardo Salcido Vazquez
- Edward Geltman
- Edward Portnay
- Egon Lenner
- Eileen O'Meara
- Einas Elmahi
- Eiran Gorodeski
- Elena Cowan
- Elena Kosmacheva
- Elena Kulibaba
- Elena Shutemova
- Ellis Lader
- Elvin Kedhi
- Erberto Carluccio
- Eric Decoulx
- Eric Klug
- Erik Hajko
- Ersel Onrat
- Ertugrul Okuyan
- Erwan Donal
- Eugene Chung
- Eugene Joseph Bauerlein
- Euler Roberto Fernandes Manenti
- Eva Goncalvesova
- Eva Peterfai
- Ewa Kalecinska-Krystkiewicz
- Ewa Straburzynska-Migaj
- Fabiana Rollini
- Fabio Silveira
- Fady I Malik
- Faiez Zannad
- Faisal Wahid
- Fang J. C.
- Farid Jadbabaie
- Felice Achilli
- Felix Ramires
- Feng Liu
- Ferenc Lakatos
- Fernando Bacal
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- Voors A. A.
- Vyacheslav Mareev
- Vyacheslav Ryabov
- W Schuyler Jones
- Wael AboAuda
- Wakaya Fujiwara
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- Wayne Gray
- Weiheng Wu
- Weimar Kunz Barroso de Souza
- Weimin Li
- Wentang Niu
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- William Nelson
- William Randall
- Wissam Khalife
- Xin Fu
- Xuelian Zhang
- Xuming Yang
- Yafei Mi
- Yajun Han
- Yang Zheng
- Yanling Qu
- Yann Rosamel
- Yasuchika Takeishi
- Yasuhiro Maejima
- Yasuki Kihara
- Yasunori Ueda
- Yasuo Okumura
- Yasushi Sakata
- Yevgeniya Svishchenko
- Yi Wang
- Yilmaz M. B.
- Yinjun Li
- Yorihiko Higashino
- Yoshihiko Saito
- Yoshiki Hata
- Yoshinori Yasaka
- Yoshitoshi Urabe
- Yu Wei
- Yuemin Sun
- Yugang Dong
- Yuhui Zhang
- Yuji Nakazato
- Yukihiko Momiyama
- Yukihito Sato
- Yukiko Morita
- Yuksel Cavusoglu
- Yuqing Zhang
- Yurii Lymar
- Yuriy Mostovoy
- Yury Lukyanov
- Yury Shvarts
- Yutaka Akatsuka
- Yves Pesant
- Zannad F.
- Zbigniew Bednarkiewicz
- Zbigniew Chmielak
- Zbigniew Gola
- Zbigniew Kalarus
- Zbigniew Pijanowski
- Zbynek Pozdisek
- Zdenek Coufal
- Zdenek Klimsa
- Zdenek Monhart
- Zehra Lale Koldas
- Zerrin Yigit
- Zhanna Kobalava
- Zhanquan Li
- Zhaoping Li
- Zhe Zheng
- Zhenyu Yang
- Zhifang Wang
- Zoltan Laszlo
- Zsolt Zilahi
- Zuyi Yuan
- Zuzana Motovska
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2021
- Field of study
BACKGROUND The selective cardiac myosin activator omecamtiv mecarbil has been shown to improve cardiac function in patients with heart failure with a reduced ejection fraction. Its effect on cardiovascular outcomes is unknown. METHODS We randomly assigned 8256 patients (inpatients and outpatients) with symptomatic chronic heart failure and an ejection fraction of 35% or less to receive omecamtiv mecarbil (using pharmacokinetic-guided doses of 25 mg, 37.5 mg, or 50 mg twice daily) or placebo, in addition to standard heart-failure therapy. The primary outcome was a composite of a first heart-failure event (hospitalization or urgent visit for heart failure) or death from cardiovascular causes. RESULTS During a median of 21.8 months, a primary-outcome event occurred in 1523 of 4120 patients (37.0%) in the omecamtiv mecarbil group and in 1607 of 4112 patients (39.1%) in the placebo group (hazard ratio, 0.92; 95% confidence interval [CI], 0.86 to 0.99; P = 0.03). A total of 808 patients (19.6%) and 798 patients (19.4%), respectively, died from cardiovascular causes (hazard ratio, 1.01; 95% CI, 0.92 to 1.11). There was no significant difference between groups in the change from baseline on the Kansas City Cardiomyopathy Questionnaire total symptom score. At week 24, the change from baseline for the median N-terminal pro-B-type natriuretic peptide level was 10% lower in the omecamtiv mecarbil group than in the placebo group; the median cardiac troponin I level was 4 ng per liter higher. The frequency of cardiac ischemic and ventricular arrhythmia events was similar in the two groups. CONCLUSIONS Among patients with heart failure and a reduced ejection, those who received omecamtiv mecarbil had a lower incidence of a composite of a heart-failure event or death from cardiovascular causes than those who received placebo. (Funded by Amgen and others; GALACTIC-HF ClinicalTrials.gov number, NCT02929329; EudraCT number, 2016 -002299-28.)