1,711 research outputs found
Is the Lambda CDM Model Consistent with Observations of Large-Scale Structure?
The claim that large-scale structure data independently prefers the Lambda
Cold Dark Matter model is a myth. However, an updated compilation of
large-scale structure observations cannot rule out Lambda CDM at 95%
confidence. We explore the possibility of improving the model by adding Hot
Dark Matter but the fit becomes worse; this allows us to set limits on the
neutrino mass.Comment: To appear in Proceedings of "Sources and Detection of Dark
Matter/Energy in the Universe", ed. D. B. Cline. 6 pages, including 2 color
figure
Chemical trends in the Galactic halo from APOGEE data
Indexación: Web of Science; Scopus.The galaxy formation process in the A cold dark matter scenario can be constrained from the analysis of stars in the Milky Way's halo system. We examine the variation of chemical abundances in distant halo stars observed by the Apache Point Observatory Galactic Evolution Experiment ( APOGEE), as a function of distance from the Galactic Centre ( r) and iron abundance ([M/H]), in the range 5 less than or similar to r less than or similar to 30 kpc and - 2.5 15 kpc and [M/H] > - 1.1 (larger in the case of O, Mg, and S) with respect to the nearest halo stars. This result confirms previous claims for low-alpha stars found at larger distances. Chemical differences in elements with other nucleosynthetic origins (Ni, K, Na, and Al) are also detected. C and N do not provide reliable information about the interstellar medium from which stars formed because our sample comprises red giant branch and asymptotic giant branch stars and can experience mixing of material to their surfaces.https://academic.oup.com/mnras/article-lookup/doi/10.1093/mnras/stw286
Toward High-Precision Measures of Large-Scale Structure
I review some results of estimation of the power spectrum of density
fluctuations from galaxy redshift surveys and discuss advances that may be
possible with the Sloan Digital Sky Survey. I then examine the realities of
power spectrum estimation in the presence of Galactic extinction, photometric
errors, galaxy evolution, clustering evolution, and uncertainty about the
background cosmology.Comment: 24 pages, including 11 postscript figures. Uses crckapb.sty (included
in submission). To appear in ``Ringberg Workshop on Large-Scale Structure,''
ed D. Hamilton (Kluwer, Amsterdam), p. 39
Anti-tumor therapy with macroencapsulated endostatin producer cells
<p>Abstract</p> <p>Background</p> <p>Theracyte is a polytetrafluoroethylene membrane macroencapsulation system designed to induce neovascularization at the tissue interface, protecting the cells from host's immune rejection, thereby circumventing the problem of limited half-life and variation in circulating levels. Endostatin is a potent inhibitor of angiogenesis and tumor growth. Continuous delivery of endostatin improves the efficacy and potency of the antitumoral therapy. The purpose of this study was to determine whether recombinant fibroblasts expressing endostatin encapsulated in Theracyte immunoisolation devices can be used for delivery of this therapeutic protein for treatment of mice bearing B16F10 melanoma and Ehrlich tumors.</p> <p>Results</p> <p>Mice were inoculated subcutaneously with melanoma (B16F10 cells) or Ehrlich tumor cells at the foot pads. Treatment began when tumor thickness had reached 0.5 mm, by subcutaneous implantation of 10<sup>7 </sup>recombinant encapsulated or non-encapsulated endostatin producer cells. Similar melanoma growth inhibition was obtained for mice treated with encapsulated or non-encapsulated endostatin-expressing cells. The treatment of mice bearing melanoma tumor with encapsulated endostatin-expressing cells was decreased by 50.0%, whereas a decrease of 56.7% in tumor thickness was obtained for mice treated with non-encapsulated cells. Treatment of Ehrlich tumor-bearing mice with non-encapsulated endostatin-expressing cells reduced tumor thickness by 52.4%, whereas lower tumor growth inhibition was obtained for mice treated with encapsulated endostatin-expressing cells: 24.2%. Encapsulated endostatin-secreting fibroblasts failed to survive until the end of the treatment. However, endostatin release from the devices to the surrounding tissues was confirmed by immunostaining. Decrease in vascular structures, functional vessels and extension of the vascular area were observed in melanoma microenvironments.</p> <p>Conclusions</p> <p>This study indicates that immunoisolation devices containing endostatin-expressing cells are effective for the inhibition of the growth of melanoma and Ehrlich tumors.</p> <p>Macroencapsulation of engineered cells is therefore a reliable platform for the refinement of innovative therapeutic strategies against tumors.</p
Properties of Galaxies in and around Voids
Two surveys for intrinsically faint galaxies towards nearby voids have been
conducted at the MPI f\"ur Astronomie, Heidelberg. One selected targets from a
new diameter limited () catalog with morphological criteria while
the other used digitized objective prism Schmidt plates to select mainly HII
dwarf galaxies. For some 450 galaxies, redshifts and other optical data were
obtained. We studied the spatial distribution of the sample objects, their
luminosity function, and their intrinsic properties. Most of the galaxies
belong to already well known sheets and filaments. But we found about a dozen
highly isolated galaxies in each sample (nearest neighborhood distance ). These tend to populate additional structures and are not
distributed homogeneously throughout the voids. As our results on 'void
galaxies' still suffer from small sample statistics, I also tried to combine
similar existing surveys of nearby voids to get further hints on the larger
structure and on the luminosity function of the isolated galaxies. No
differences in the luminosity function of sheet and void galaxies could be
found. The optical and infrared properties of both samples are in the normal
range for samples dominated by late-type dwarfs. Follow-up HI studies show that
the isolated dwarfs in both samples have unusual high amount of neutral gas for
a given luminosity.Comment: 10 pages, 4 figures, latex, to appear in the proceedings of the
'Ringberg workshop on Large Scale Structure', hold Sep. 23-28, 199
Stellar Population Diagnostics of Elliptical Galaxy Formation
Major progress has been achieved in recent years in mapping the properties of
passively-evolving, early-type galaxies (ETG) from the local universe all the
way to redshift ~2. Here, age and metallicity estimates for local cluster and
field ETGs are reviewed as based on color-magnitude, color-sigma, and
fundamental plane relations, as well as on spectral-line indices diagnostics.
The results of applying the same tools at high redshifts are then discussed,
and their consistency with the low-redshift results is assessed. Most low- as
well as high-redshift (z~1) observations consistently indicate 1) a formation
redshift z>~3 for the bulk of stars in cluster ETGs, with their counterparts in
low-density environments being on average ~1-2 Gyr younger, i.e., formed at
z>~1.5-2, 2) the duration of the major star formation phase anticorrelates with
galaxy mass, and the oldest stellar populations are found in the most massive
galaxies. With increasing redshift there is evidence for a decrease in the
number density of ETGs, especially of the less massive ones, whereas existing
data appear to suggest that most of the most-massive ETGs were already fully
assembled at z~1. Beyond this redshift, the space density of ETGs starts
dropping significantly, and as ETGs disappear, a population of massive,
strongly clustered, starburst galaxies progressively becomes more and more
prominent, which makes them the likely progenitors to ETGs.Comment: To appear on Annual Review of Astronomy & Astrophysics, Vol. 44
(2006). 46 pages with 16 figures. Replaced version includes updated
references, few typos less, and replaces Fig. 11 and Fig. 16 which had been
skrewed u
Neural development features: Spatio-temporal development of the Caenorhabditis elegans neuronal network
The nematode Caenorhabditis elegans, with information on neural connectivity,
three-dimensional position and cell linage provides a unique system for
understanding the development of neural networks. Although C. elegans has been
widely studied in the past, we present the first statistical study from a
developmental perspective, with findings that raise interesting suggestions on
the establishment of long-distance connections and network hubs. Here, we
analyze the neuro-development for temporal and spatial features, using birth
times of neurons and their three-dimensional positions. Comparisons of growth
in C. elegans with random spatial network growth highlight two findings
relevant to neural network development. First, most neurons which are linked by
long-distance connections are born around the same time and early on,
suggesting the possibility of early contact or interaction between connected
neurons during development. Second, early-born neurons are more highly
connected (tendency to form hubs) than later born neurons. This indicates that
the longer time frame available to them might underlie high connectivity. Both
outcomes are not observed for random connection formation. The study finds that
around one-third of electrically coupled long-range connections are late
forming, raising the question of what mechanisms are involved in ensuring their
accuracy, particularly in light of the extremely invariant connectivity
observed in C. elegans. In conclusion, the sequence of neural network
development highlights the possibility of early contact or interaction in
securing long-distance and high-degree connectivity
Depression in medical students: insights from a longitudinal study
Background: Factors associated with depression of medical students are poorly understood. The purpose of this study is to determine the prevalence of depression in medical students, its change during the course, if depression persists for affected students, what are the factors associated with depression and how these factors change over time.
Methods: A prospective, longitudinal observational study was conducted at the Medical School of the University of Minho, Portugal, between academic years 2009-2010 to 2012-2013. We included students who maintained their participation by annually completing a questionnaire including Beck Depression Inventory (BDI). Anxiety and burnout were assessed using the State Trait Anxiety Inventory and Maslach Burnout Inventory. Surveys on socio-demographic variables were applied to evaluate potential predictors, personal and academic characteristics and perceived difficulties. ANOVA with multiple comparisons were used to compare means of BDI score. The medical students were organized into subgroups by K-means cluster analyses. ANOVA mixed-design repeated measurement was performed to assess a possible interaction between variables associated with depression.
Results: The response rate was 84, 92, 88 and 81% for academic years 2009-2010, 2010-2011,2011-2012 and 2012/2013, respectively. Two hundred thirty-eight medical students were evaluated longitudinally. For depression the prevalence ranged from 21.5 to 12.7% (academic years 2009/2010 and 2012/2013). BDI scores decreased during medical school. 19.7% of students recorded sustained high BDI over time. These students had high levels of trait-anxiety and choose medicine for anticipated income and prestige, reported more relationship issues, cynicism, and decreased satisfaction with social activities. Students with high BDI scores at initial evaluation with low levels of trait-anxiety and a primary interest in medicine as a career tended to improve their mood and reported reduced burnout, low perceived learning problems and increased satisfaction with social activities at last evaluation. No difference was detected between men and women in the median BDI score over time.
Conclusions: Our findings suggest that personal factors (anxiety traits, medicine choice factors, relationship patterns and academic burnout) are relevant for persistence of high levels of BDI during medical training. Medical schools need to identity students who experience depression and support then, as early as possible, particularly when depression has been present over time.info:eu-repo/semantics/publishedVersio
The use of zootherapeutics in folk veterinary medicine in the district of Cubati, Paraíba State, Brazil
<p>Abstract</p> <p>Background</p> <p>The present work addresses the use of zootherapy in folk veterinary medicine (ethnoveterinary) by the residents of the municipal district of Cubati, microregion of Seridó, Paraíba State, Brazil. It sought to identify the principal animals used as medicinal sources for zootherapeutics and to contribute to the preservation and sustainability of this traditional knowledge.</p> <p>Methods</p> <p>Field research was undertaken on a weekly or biweekly basis during the period November, 2006, to January, 2007. Free, semi-structured, and open interviews were made with local residents of the municipal district of Cubati (in both urban and rural settings) as well as with venders in public markets. A total of 25 individuals of both sexes were interviewed (with ages varying from 26 to 78 years) although only 16 were finally chosen as informants as these people demonstrated the greatest degree of knowledge concerning zootherapeutics. Graphs and percentages were generated using Microsoft<sup>© </sup>Excel 2007 software, and the species were identified by photographic registration and subsequent bibliographical surveys.</p> <p>Results</p> <p>Mammals constitute the main medicinal zootherapeutic source for folk veterinary medicines in the studied area, both in terms of the total number of species used and the frequency of their citation. Sheep (<it>Ovis aries</it>), pigs (<it>Sus scrofa</it>), cattle (<it>Bos taurus</it>), and foxes (<it>Cerdocyon thous</it>) were mentioned by 62.5, 43.75, 37.5, and 31.25% of the informants, respectively, as being used in folk veterinary medicine. Additionally, chameleons (<it>Iguana iguana</it>), chickens (<it>Gallus domesticus</it>), and rattlesnakes (<it>Crotalus durissus</it>) were mentioned by 75, 43.75, and 31.25% of the informants, respectively. Relatively simple animal illnesses, such as furuncles, or injuries resulting from embedded thorns or skin eruptions are responsible for the largest number of zootherapeutic treatment, while, diseases of greater complexity, such as rabies and brucellosis, were not even mentioned. Fat from various animals constituted the most frequently cited resource used for its medicinal-veterinary properties.</p> <p>Conclusion</p> <p>The examination of folk knowledge and health practices allows a better understanding of human interactions with their local environment, and aids in the formulation of appropriate strategies for natural resource conservation.</p
Cold gas accretion in galaxies
Evidence for the accretion of cold gas in galaxies has been rapidly
accumulating in the past years. HI observations of galaxies and their
environment have brought to light new facts and phenomena which are evidence of
ongoing or recent accretion:
1) A large number of galaxies are accompanied by gas-rich dwarfs or are
surrounded by HI cloud complexes, tails and filaments. It may be regarded as
direct evidence of cold gas accretion in the local universe. It is probably the
same kind of phenomenon of material infall as the stellar streams observed in
the halos of our galaxy and M31. 2) Considerable amounts of extra-planar HI
have been found in nearby spiral galaxies. While a large fraction of this gas
is produced by galactic fountains, it is likely that a part of it is of
extragalactic origin. 3) Spirals are known to have extended and warped outer
layers of HI. It is not clear how these have formed, and how and for how long
the warps can be sustained. Gas infall has been proposed as the origin. 4) The
majority of galactic disks are lopsided in their morphology as well as in their
kinematics. Also here recent accretion has been advocated as a possible cause.
In our view, accretion takes place both through the arrival and merging of
gas-rich satellites and through gas infall from the intergalactic medium (IGM).
The infall may have observable effects on the disk such as bursts of star
formation and lopsidedness. We infer a mean ``visible'' accretion rate of cold
gas in galaxies of at least 0.2 Msol/yr. In order to reach the accretion rates
needed to sustain the observed star formation (~1 Msol/yr), additional infall
of large amounts of gas from the IGM seems to be required.Comment: To appear in Astronomy & Astrophysics Reviews. 34 pages.
Full-resolution version available at
http://www.astron.nl/~oosterlo/accretionRevie
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