1,398 research outputs found
Benchmarking Treatment Response in Touretteâs Disorder: A Psychometric Evaluation and Signal Detection Analysis of the Parent Tic Questionnaire
This study assessed the psychometric properties of a parent-reported tic severity measure, the Parent Tic Questionnaire (PTQ), and used the scale to establish guidelines for delineating clinically significant tic treatment response. Participants were 126 children ages 9 to 17 who participated in a randomized controlled trial of Comprehensive Behavioral Intervention for Tics (CBIT). Tic severity was assessed using the Yale Global Tic Severity Scale (YGTSS), Hopkins Motor/Vocal Tic Scale (HMVTS) and PTQ; positive treatment response was defined by a score of 1 (very much improved) or 2 (much improved) on the Clinical Global Impressions â Improvement (CGI-I) scale. Cronbachâs alpha and intraclass correlations (ICC) assessed internal consistency and test-retest reliability, with correlations evaluating validity. Receiver- and Quality-Receiver Operating Characteristic analyses assessed the efficiency of percent and raw-reduction cutoffs associated with positive treatment response. The PTQ demonstrated good internal consistency (α = 0.80 to 0.86), excellent test-retest reliability (ICC = .84 to .89), good convergent validity with the YGTSS and HM/VTS, and good discriminant validity from hyperactive, obsessive-compulsive, and externalizing (i.e., aggression and rule-breaking) symptoms. A 55% reduction and 10-point decrease in PTQ Total score were optimal for defining positive treatment response. Findings help standardize tic assessment and provide clinicians with greater clarity in determining clinically meaningful tic symptom change during treatment
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Evaluation of Daphnia ambigua for Routine Aquatic Toxicity Testing at the Savannah River Site
Short-term whole effluent toxicity testing, which is currently a requirement of the U.S. EPA`s National Pollution Discharge Elimination System (NPDES), commonly uses the cladoceran species Ceriodaphnia dubia. Despite the advantages to using a common test species to model the toxic effects of effluents, it could be argued that toxicity test results would be more meaningful if a wider variety of test organisms were commonly used. One particular argument against C. dubia is that tests conducted with this species do not always reflect local, site-specific conditions. The careful selection and use of an indigenous test species would produce a more realistic model of local instream effects and would account for regional differences in water quality. Permitted effluent discharges from Savannah River Site (SRS), a government weapons facility operated by the U.S. Department of Energy, require toxicity testing with C. dubia. However, water quality in these receiving streams is markedly different (lower pH and hardness) from standard laboratory water used for the culturing and testing of C. dubia, and it has been shown that this receiving water presents varying degrees of toxicity to C. dubia. Based on these results, it is possible that toxic effects observed during an effluent study could be the result of test organism stress from the dilution water and not the effects of SRS effluents. Therefore, this study addressed the substitution of C. dubia with an indigenous cladoceran species, Daphnia ambigua for routine regulatory testing at SRS. Given the indigenous nature of this species, combined with the fact that it has been successfully cultured by other investigators, D. ambigua was ideal for consideration as a replacement for C. dubia, but further study of the overall success and sensitivity of laboratory-reared D. ambigua was required. This investigation determined that D. ambigua could be laboratory cultured with only minimal changes to established regulatory protocol and that the life-cycle characteristics of this species were conducive to traditional acute and chronic aquatic toxicity test methods. Acute toxicity tests showed that when comparing LC50 values for C. dubia and D. ambigua, D. ambigua was less sensitive to some toxicants (sodium chloride, copper sulfate, and sodium lauryl sulfate) while more sensitive to others (chlorpyrifos). Results of chronic tests with copper sulfate and sodium chloride resulted in the same NOEC/LOEC values for both species. When exposed to unaltered SRS stream water, C. dubia demonstrated a `toxic` response for two of the three streams tested, while reproduction for D. ambigua was higher in all stream samples. Acute toxicity tests with sodium chloride in stream water, generally followed the sensitivity trend noted in tests conducted with regular laboratory water
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Rapid bioassessment methods for assessing the toxicity of terrestrial waste sites at the Savannah River Site using the earthworm, Eisenia foetida
Studies were conducted to assess the feasibility of using the earthworm, Eisenia foetida, to evaluate the toxicity of contaminated soils at the Savannah River Site. Survival was assessed in several uncontaminated soils, including sandy loams and clayey loams, as well as in soils contaminated with coal fines, ash, diesel fuel, and heavy metals. In addition, behavior responses, changes in biomass, and bioaccumulation of heavy metals were assessed as sublethal indicators of toxicity. The results indicate excellent survival of Eisenia foetida in uncontaminated sandy and clayey soils. No amendment of these uncontaminated soils or addition of food was necessary to sustain the worms for the 14-day test period. In contaminated soils, no significant mortality was observed, except in soils which have very low pH (< 3). However, sublethal responses were observed in earthworms exposed to several of the contaminated soils. These responses included worms clumping on the surface of the soil, worms clumping between the sides of the test container and the soil, increased burrowing times, reductions in biomass, and elevated concentrations of heavy metals in worm tissue
Rationality of quotients by linear actions of affine groups
Let G be the (special) affine group, semidirect product of SL_n and C^n. In
this paper we study the representation theory of G and in particular the
question of rationality for V/G where V is a generically free G-representation.
We show that the answer to this question is positive if the dimension of V is
sufficiently large and V is indecomposable. We have a more precise theorem if V
is a two-step extension 0 -> S -> V -> Q -> 0 with S, Q completely reducible.Comment: 18 pages; dedicated to Fabrizio Catanese on the occasion of his 60th
birthda
Generalized Involution Models for Wreath Products
We prove that if a finite group has a generalized involution model, as
defined by Bump and Ginzburg, then the wreath product also has a
generalized involution model. This extends the work of Baddeley concerning
involution models for wreath products. As an application, we construct a
Gelfand model for wreath products of the form with abelian, and
give an alternate proof of a recent result due to Adin, Postnikov, and Roichman
describing a particularly elegant Gelfand model for the wreath product \ZZ_r
\wr S_n. We conclude by discussing some notable properties of this
representation and its decomposition into irreducible constituents, proving a
conjecture of Adin, Roichman, and Postnikov's.Comment: 29 page
Coulomb Blockade in low mobility nanometer size Si:MOSFETs
We investigate coherent transport in Si:MOSFETs with nominal gate lengths 50
to 100nm and various widths at very low temperature. Independent of the
geometry, localized states appear when G=e^{2}/h and transport is dominated by
resonant tunnelling through a single quantum dot formed by an impurity
potential. We find that the typical size of the relevant impurity quantum dot
is comparable to the channel length and that the periodicity of the observed
Coulomb blockade oscillations is roughly inversely proportional to the channel
length. The spectrum of resonances and the nonlinear I-V curves allow to
measure the charging energy and the mean level energy spacing for electrons in
the localized state. Furthermore, we find that in the dielectric regime, the
variance var(lng) of the logarithmic conductance lng is proportional to its
average value consistent with one-electron scaling models.Comment: 4 pages, 4 figure
Lattice instabilities of PbZrO3/PbTiO3 [1:1] superlattices from first principles
Ab initio phonon calculations for the nonpolar reference structures of the
(001), (110), and (111) PbZrO_3/PbTiO_3 [1:1] superlattices are presented. The
unstable polar modes in the tetragonal (001) and (110) structures are confined
in either the Ti- or the Zr-centered layers and display two-mode behavior,
while in the cubic (111) case one-mode behavior is observed. Instabilities with
pure oxygen character are observed in all three structures. The implications
for the ferroelectric behavior and related properties are discussed.Comment: 12 pages, 2 figures, 7 tables, submitted to PR
New learning opportunities in a networked world: developing a research agenda on innovative uses of ICTS for learning and teaching
IDRC Project Title: Developing a Research Agenda on Expanding New Digital Learning Opportunities in Developing Countries;IDRC Project Number: 107628The report describes outcomes of the activities carried out for the project âNew Learning Opportunities in a Networked World: Developing a Research Agenda on Innovative uses of ICTs for Learning and Teachingâ. The research consists of three main activities, namely desk research, written expert consultation and group concept mapping study involving a 2-day workshop and a follow-up with experts who could not attend the workshop. These activities are interconnected elements of the consultative approach to establishing a research agenda.International Development Research Centre (IDRC), Canad
Light emission from a scanning tunneling microscope: Fully retarded calculation
The light emission rate from a scanning tunneling microscope (STM) scanning a
noble metal surface is calculated taking retardation effects into account. As
in our previous, non-retarded theory [Johansson, Monreal, and Apell, Phys. Rev.
B 42, 9210 (1990)], the STM tip is modeled by a sphere, and the dielectric
properties of tip and sample are described by experimentally measured
dielectric functions. The calculations are based on exact diffraction theory
through the vector equivalent of the Kirchoff integral. The present results are
qualitatively similar to those of the non-retarded calculations. The light
emission spectra have pronounced resonance peaks due to the formation of a
tip-induced plasmon mode localized to the cavity between the tip and the
sample. At a quantitative level, the effects of retardation are rather small as
long as the sample material is Au or Cu, and the tip consists of W or Ir.
However, for Ag samples, in which the resistive losses are smaller, the
inclusion of retardation effects in the calculation leads to larger changes:
the resonance energy decreases by 0.2-0.3 eV, and the resonance broadens. These
changes improve the agreement with experiment. For a Ag sample and an Ir tip,
the quantum efficiency is 10 emitted photons in the visible
frequency range per tunneling electron. A study of the energy dissipation into
the tip and sample shows that in total about 1 % of the electrons undergo
inelastic processes while tunneling.Comment: 16 pages, 10 figures (1 ps, 9 tex, automatically included); To appear
in Phys. Rev. B (15 October 1998
Shaping the Phase of a Single Photon
While the phase of a coherent light field can be precisely known, the phase
of the individual photons that create this field, considered individually,
cannot. Phase changes within single-photon wave packets, however, have
observable effects. In fact, actively controlling the phase of individual
photons has been identified as a powerful resource for quantum communication
protocols. Here we demonstrate the arbitrary phase control of a single photon.
The phase modulation is applied without affecting the photon's amplitude
profile and is verified via a two-photon quantum interference measurement,
which can result in the fermionic spatial behaviour of photon pairs. Combined
with previously demonstrated control of a single photon's amplitude, frequency,
and polarisation, the fully deterministic phase shaping presented here allows
for the complete control of single-photon wave packets.Comment: 4 pages, 4 figure
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