THE HEMOSTATIC ACTIVITY OF BIS (2-AMINOETHAN-1-SULFONATE) CALCIUM

Objective: It is known that local or systemic injection of hemostatic drugs is used to reduce blood loss and number of blood transfusions in patients with hypocoagulation and hemorrhagic diathesis. However, the analysis of literature data shows that the drugs applied for the control of bleeding, traditionally used in medical practice, are not effective enough. This study deals with the systemic hemostatic activity of bis (2-aminoethan-1- sulfonate) calcium in the experiment.Methods: Experimental work in vitro is performed on the blood of healthy male donors, under conditions in vivo it is done on intraperitoneal injection in male rats. Thromboelastography was carried out with apparatus Thromboelastography (TEG) 5000 (Haemoscope Corporation, United States). The influence of first synthesized derivative and ethamsylate on functional activity of platelets was studied using a platelet aggregation analyzer Biola 230LA†(Russia). Experimental evaluation of the system specific hemostatic activity in vivo was carried out using the model of parenchymatous bleeding in mature male rats. The interference came amid registration of bleeding stop time and extent of blood loss.Results: Bis (2-aminoethan-1-sulfonate) calcium shows procoagulation and proaggregant activity both in vitro and in vivo. Proaggregatory effect of bis (2-aminoethan-1-sulfonate) calcium is successfully implemented in the systemic hemostatic activity in terms of parenchymal bleeding, surpassing the control group and the group of etamsylate.Conclusion: The results of these studies reveal potentially high systemic hemostatic activity of bis (2-aminoethan-1-sulfonate) calcium, urging the need for further study on this compound and its analogs to create on their basis highly efficient, selective correctors of the hemostatic system

To the problem of optimization design air boiler heat exchange element scheme IGCC

Different approaches are considered for calculating the heat exchange element of an air boiler. The technical characteristics of the heat exchange element, namely the heat transfer coefficient, specific surface area, length and air speed, are studied, depending on the pipe diameter and air.Рассмотрены различные подходы для расчета теплообменного элемента воздушного котла. Исследованы технические характеристики теплообменного элемента, а именно коэффициент теплоотдачи, удельная поверхность, длина теплообменного элемента и скорость воздуха, в зависимости от диаметра труб и давления воздуха

DIAMETER INFLUENCE DETERMINATION OF THE EXCHANGE ELEMENT ON THE HIGH TEMPERATURE COMPRESSED AIR HEATER HEATING SURFACES UNIT COST

In the work heat exchange element is considered a high-temperature compressed air heater. The influence of the tubular heat exchanger element diameter in the heating surfaces unit cost and obtained its optimal parameters.В работе рассмотрен теплообменный элемент высокотемпературного воздухонагревателя компримированного воздуха. Проанализировано влияние диаметра трубного теплообменного элемента на удельные затраты поверхностей нагрева и получены его оптимальные параметры

The role of cytokines in the mechanism of development of chronic generalized periodontitis

The article presents information on the role of cytokines in the pathogenetic mechanisms of development of chronic inflammation in periodontal tissues. The aim of the study was the investigation of the mechanisms of cytokine regulation in chronic inflammatory process in periodontal tissues in patients with chronic generalized periodontitis and brakesman. Methodology. The object of study steel 317 patients with periodontal disease easy and moderate severity. Investigated in oral fluid range of cytokines to determine their role in the pathogenetic mechanisms of development of chronic inflammation in periodontal tissues. The control group consisted of 112 people. Both groups were matched for age and sex. Results. Among patients with chronic generalized periodontitis were identified statisticheski significant imbalance of Pro - and anti-inflammatory cytokines. State changes in the status of cytokines has allowed to determine the informative criteria with prognathic value in the oral fluid, contributing to reduction in inflammation. Conclusions. The revealed changes testify to the breakdown of adaptive processes and the development of clinical symptoms of periodontal disease.В статье представлены сведения о роли цитокинов в патогенетических механизмах развития хронического воспаления в тканях пародонта. Целью исследования послужило изучение механизмов цитокиновой регуляции при хроническом воспалительном процессе в тканях пародонта у пациентов с хроническим генерализованным пародонтитом и брукизмом. Методология. Объектом изучения стали 317 пациентов, имеющих заболевание пародонта легкой и средней степени тяжести. Исследовали в ротовой жидкости спектр цитокинов для выявления их роли в патогенетических механизмах развития хронического воспаления в тканях пародонта. Группу контроля составили 112 человек. Обе группы были сопоставимы по возрасту и полу. Результаты. Среди пациентов с хроническим генерализованным пародонтитом был выявлен статитически значимый дисбаланс про- и противовоспалительных цитокинов. Изменения состояния в их статусе цитокинов позволили определить информативные критерии обладающие прогнатической ценностью в ротовой жидкости, способствующие купированию воспалительных процессов. Выводы. Выявленные изменения свидетельствуют о срыве адаптационных процессов и развитии клинических симптомов заболевания пародонта

SAFETY AND EFFECTIVENESS OF INTRAARTICULAR ADMINISTRATION OF ADIPOSE-DERIVED STROMAL VASCULAR FRACTION FOR TREATMENT OF KNEE ARTICULAR CARTILAGE DEGENERATIVE DAMAGE: PRELIMINARY RESULTS OF A CLINICAL TRIAL

The incidence of knee osteoarthritis tends to increase every year and constitutes more than 83% of overall OA morbidity. Moreover, the OA morbidity among younger patients is also increasing. However, currently available treatment methods do not provide quite satisfactory outcomes.Purpose of the study – to evaluate safety and efficacy of intraarticular introduction of autologous adipose-derived stromal vascular fraction for treatment of knee osteoarthritis.Material and methods. By the moment of writing the present report, 28 patients were included into the study. All patients underwent tumescent liposuction under local anesthesia. The stromal vascular fraction was isolated from lipoaspirate within 1,5 hours after harvesting and subsequently injected into the articular cavity. Follow-up period was 6 months after injections. The authors report on efficacy data of 10 patients who completed the study according to protocol and safety data of all 28 patients. Efficacy was evaluated basing on laboratory assessments and patient’s subjective assessment by validated questionnaires.Results. Neither adverse reactions no adverse events were observed. Significant decrease of pain severity by VAS was noted in one week after injection and pain score continued decreasing during the whole follow up period. The increase of KOOS score was noted starting on the fifth week after injection. KSS part 1 score increased in 8 weeks, KSS part 2 score — in 6 months after injection. Physical health, assessed with SF-36 questionnaire significantly improved in 2 and 6 months after the procedure. There was a clear trend towards improvement of mental health.Conclusion. Preliminary results of clinical study suggest intraarticular injection of autologous adipose-derived stromal vascular fraction to be a safe and efficient method of the treatment of knee osteoarthritis

Эффективность и безопасность эрибулина при различных подтипах рака молочной железы: данные из реальной клинической практики в России

The article presents a pooled experience of the use of eribulin in the real clinical practice of treatment of metastatic breast cancer in Russian oncological institutions. The effectiveness of the drug in monotherapy with HER2‑negative breast cancer was analyzed, groups of patients with most effective use of eribulin were identified depending on the localization of metastases, the most effective lines of therapy. The effectiveness of the drug in combination with trastuzumab in HER2‑positive breast cancer is described, as well as toxic reactions. В статье представлен обобщенный опыт применения эрибулина в реальной клинической практике онкологических учреждений РФ при метастатическом раке молочной железы. Проанализирована эффективность препарата в монотерапии при HER2-отрицательном раке молочных желез, выделены группы больных в зависимости от локализации метастазов, линии терапии, в которых препарат оказался максимально эффективным. Описана эффективность препарата в комбинации с трастузумабом при HER2-положительном раке молочной железы, а также токсические реакции. 

Peculiarity of implementation of the national cultural code in tatar poetry and prose of the second half of the XX century

© BEIESP. The study of the specifics of the manifestation of cultural codes in Tatar poetry and prose of the second half of the 20th century is of great scientific and practical interest. The timeliness of the chosen topic is conditioned by the need to identify the uniqueness, originality of Tatar national poetry and prose of the given period. At the same time, it should be noted that Tatar poetry and prose of the period of returning to national origins has not undergone comprehensive, holistic, detailed, structural study in terms of reflecting national identity. The goal of research: Systematic and comprehensive study of the creative work of Tatar writers of the second half of the 20th century in respect of the aspect of the specifics of the manifestation of the national cultural code in them, identifying the nature of literary interactions and interrelations with Russian literature. The article deals with the specifics of the implementation of the Tatar national cultural code in the works of Amirkhan Eniki, Mirgaziyan Yunys, Ravil Bukharaev, Zulfat, Robert Minnullin, Renat Haris, Hassan Tufan and Ildar Yuzeev. The works under study reflect the Tatar national worldview and contain its main components: The image of homeland and native land, national holidays, moral and spiritual values and the history of the Tatar people. They also reflect the organic connection of the creative work of these writers and poets with the Tatar national culture and literature

Peculiarity of implementation of the national cultural code in tatar poetry and prose of the second half of the XX century

© BEIESP. The study of the specifics of the manifestation of cultural codes in Tatar poetry and prose of the second half of the 20th century is of great scientific and practical interest. The timeliness of the chosen topic is conditioned by the need to identify the uniqueness, originality of Tatar national poetry and prose of the given period. At the same time, it should be noted that Tatar poetry and prose of the period of returning to national origins has not undergone comprehensive, holistic, detailed, structural study in terms of reflecting national identity. The goal of research: Systematic and comprehensive study of the creative work of Tatar writers of the second half of the 20th century in respect of the aspect of the specifics of the manifestation of the national cultural code in them, identifying the nature of literary interactions and interrelations with Russian literature. The article deals with the specifics of the implementation of the Tatar national cultural code in the works of Amirkhan Eniki, Mirgaziyan Yunys, Ravil Bukharaev, Zulfat, Robert Minnullin, Renat Haris, Hassan Tufan and Ildar Yuzeev. The works under study reflect the Tatar national worldview and contain its main components: The image of homeland and native land, national holidays, moral and spiritual values and the history of the Tatar people. They also reflect the organic connection of the creative work of these writers and poets with the Tatar national culture and literature