2,233 research outputs found
CARICOM Bilateral Trade: A Preliminary Analysis Using the Gravity Model
This paper investigates the determinants of intra-CARICOM bilateral trade and the CARICOM member's trade with the North American and European countries using the gravity model. Seventeen annual cross-sections are estimated for the period 1980 through 1996. Overall, the empirical results indicate that the gravity model has considerable potential to explain intra-CARICOM bilateral trade as well as trade between CARICOM members and non-members. The evidence suggests that both the importer's GDP per capita and the exporter's GDP per capita exert strong positive effects on CARICOM trade levels. Since these effects are found to be statistically the same, we conclude that the gravity model is symmetric with respect to GDP per capita. Further, sharing a common language, colonial ties, or membership in the CARICOM all significantly contribute to larger volumes of bilateral trade, while geographic distance has the opposite effect. Both the exporting and the importing countries' populations have a positive effect on trade levels, indicating that larger economies have a wider production base and thus export and import more than would smaller economies.Caribbean economies, CARICOM, FTAA, gravity model, regional integration, International Relations/Trade,
Point-contact spectroscopy in heavy-fermion superconductors
We develop a minimal model to calculate point-contact spectra between a
metallic tip and a superconducting heavy-fermion system. We apply our tunneling
model to the heavy fermion CeCoIn5, both in the normal and superconducting
state. In point-contact and scanning tunneling spectroscopy many heavy-fermion
materials, like CeCoIn5, exhibit an asymmetric differential conductance, dI/dV,
combined with a strongly suppressed Andreev reflection signal in the
superconducting state. We argue that both features may be explained in terms of
a multichannel tunneling model in the presence of localized states near the
interface. We find that it is not sufficient to tunnel into two itinerant bands
of light and heavy electrons to explain the Fano line shape of the differential
conductance. Localized states in the bulk or near the interface are an
essential component for quantum interference to occur when an electron tunnels
from the metallic tip of the point contact into the heavy-fermion system.Comment: 13 pages, 9 figures. Accepted for publication in Physical Review
Unravelling the many facets of human cooperation in an experimental study
Humans readily cooperate, even with strangers and without prospects of reciprocation. Despite thousands of studies, this finding is not well understood. Most studies focussed on a single aspect of cooperation and were conducted under anonymous conditions. However, cooperation is a multi-faceted phenomenon, involving generosity, readiness to share, fairness, trust, trustworthiness, and willingness to take cooperative risks. Here, we report findings of an experiment where subjects had to make decisions in ten situations representing different aspects of cooperation, both under anonymous and ‘personalised’ conditions. In an anonymous setting, we found considerable individual variation in each decision situation, while individuals were consistent both within and across situations. Prosocial tendencies such as generosity, trust, and trustworthiness were positively correlated, constituting a ‘cooperativeness syndrome’, but the tendency to punish non-cooperative individuals is not part of this syndrome. In a personalised setting, information on the appearance of the interaction partner systematically affected cooperation-related behaviour. Subjects were more cooperative toward interaction partners whose facial photographs were judged ‘generous’, ‘trustworthy’, ‘not greedy’, ‘happy’, ‘attractive’, and ‘not angry’ by a separate panel. However, individuals eliciting more cooperation were not more cooperative themselves in our experiment. Our study shows that a multi-faceted approach can reveal general behavioural tendencies underlying cooperation, but it also uncovers new puzzling features of human cooperation
Bubbling Orientifolds
We investigate a class of 1/2-BPS bubbling geometries associated to
orientifolds of type IIB string theory and thereby to excited states of the
SO(N)/Sp(N) N=4 supersymmetric Yang-Mills theory. The geometries are in
correspondence with free fermions moving in a harmonic oscillator potential on
the half-line. Branes wrapped on torsion cycles of these geometries are
identified in the fermi fluid description. Besides being of intrinsic interest,
these solutions may also occur as local geometries in flux compactifications
where orientifold planes are present to ensure global charge cancellation. We
comment on the extension of this procedure to M-theory orientifolds.Comment: 25 pages, 11 figures. v2: few references adde
Extended peptide-based inhibitors efficiently target the proteasome and reveal overlapping specificities of the catalytic β-subunits
AbstractBackground: The 26S proteasome is responsible for most cytosolic proteolysis, and is an important protease in major histocompatibility complex class I-mediated antigen presentation. Constitutively expressed proteasomes from mammalian sources possess three distinct catalytically active species, β1, β2 and β5, which are replaced in the γ-interferon-inducible immunoproteasome by a different set of catalytic subunits, β1i, β2i and β5i, respectively. Based on preferred cleavage of short fluorogenic peptide substrates, activities of the proteasome have been assigned to individual subunits and classified as ‘chymotryptic-like’ (β5), ‘tryptic-like’ (β2) and ‘peptidyl-glutamyl peptide hydrolyzing’ (β1). Studies with protein substrates indicate a far more complicated, less strict cleavage preference. We reasoned that inhibitors of extended size would give insight into the extent of overlapping substrate specificity of the individual activities and subunits.Results: A new class of proteasome inhibitors, considerably extended in comparison with the commonly used fluorescent substrates and peptide-based inhibitors, has been prepared. Application of the safety catch resin allowed the generation of the target compounds using a solid phase protocol. Evaluation of the new compounds revealed a set of highly potent proteasome inhibitors that target all individual active subunits with comparable affinity, unlike the other inhibitors described to date. Modification of the most active compound, adamantane-acetyl-(6-aminohexanoyl)3-(leucinyl)3-vinyl-(methyl)-sulfone (AdaAhx3L3VS), itself capable of proteasome inhibition in living cells, afforded a new set of radio- and affinity labels.Conclusions: N-terminal extension of peptide vinyl sulfones has a profound influence on both their efficiency and selectivity as proteasome inhibitors. Such extensions greatly enhance inhibition and largely obliterate selectivity towards the individual catalytic activities. We conclude that for the interaction with larger substrates, there appears to be less discrimination of different substrate sequences for the catalytic activities than is normally assumed based on the use of small peptide-based substrates and inhibitors. The compounds described here are readily accessible synthetically, and are more potent inhibitors in living cells than their shorter peptide vinyl sulfone counterparts
Experimental entanglement distillation of mesoscopic quantum states
The distribution of entangled states between distant parties in an optical
network is crucial for the successful implementation of various quantum
communication protocols such as quantum cryptography, teleportation and dense
coding [1-3]. However, owing to the unavoidable loss in any real optical
channel, the distribution of loss-intolerant entangled states is inevitably
inflicted by decoherence, which causes a degradation of the transmitted
entanglement. To combat the decoherence, entanglement distillation, which is
the process of extracting a small set of highly entangled states from a large
set of less entangled states, can be used [4-14]. Here we report on the
mesoscopic distillation of deterministically prepared entangled light pulses
that have undergone non-Gaussian noise. The entangled light pulses [15-17] are
sent through a lossy channel, where the transmission is varying in time
similarly to light propagation in the atmosphere. By employing linear optical
components and global classical communication, the entanglement is
probabilistically increased.Comment: 13 pages, 4 figures. It's the first submitted version to the Nature
Physics. The final version is already published on Nature Physics vol.4,
No.12, 919 - 923 (2008
From Gravitons to Giants
We discuss exact quantization of gravitational fluctuations in the half-BPS
sector around AdSS background, using the dual super Yang-Mills
theory. For this purpose we employ the recently developed techniques for exact
bosonization of a finite number of fermions in terms of bosonic
oscillators. An exact computation of the three-point correlation function of
gravitons for finite shows that they become strongly coupled at
sufficiently high energies, with an interaction that grows exponentially in
. We show that even at such high energies a description of the bulk physics
in terms of weakly interacting particles can be constructed. The single
particle states providing such a description are created by our bosonic
oscillators or equivalently these are the multi-graviton states corresponding
to the so-called Schur polynomials. Both represent single giant graviton states
in the bulk. Multi-particle states corresponding to multi-giant gravitons are,
however, different, since interactions among our bosons vanish identically,
while the Schur polynomials are weakly interacting at high enough energies.Comment: v2-references added, minor changes and typos corrected; 24 pages,
latex, 3 epsf figure
NQO2 is a reactive oxygen species generating off-target for acetaminophen
[Image: see text] The analgesic and antipyretic compound acetaminophen (paracetamol) is one of the most used drugs worldwide. Acetaminophen overdose is also the most common cause for acute liver toxicity. Here we show that acetaminophen and many structurally related compounds bind quinone reductase 2 (NQO2) in vitro and in live cells, establishing NQO2 as a novel off-target. NQO2 modulates the levels of acetaminophen derived reactive oxygen species, more specifically superoxide anions, in cultured cells. In humans, NQO2 is highly expressed in liver and kidney, the main sites of acetaminophen toxicity. We suggest that NQO2 mediated superoxide production may function as a novel mechanism augmenting acetaminophen toxicity
A solid state light-matter interface at the single photon level
Coherent and reversible mapping of quantum information between light and
matter is an important experimental challenge in quantum information science.
In particular, it is a decisive milestone for the implementation of quantum
networks and quantum repeaters. So far, quantum interfaces between light and
atoms have been demonstrated with atomic gases, and with single trapped atoms
in cavities. Here we demonstrate the coherent and reversible mapping of a light
field with less than one photon per pulse onto an ensemble of 10 millions atoms
naturally trapped in a solid. This is achieved by coherently absorbing the
light field in a suitably prepared solid state atomic medium. The state of the
light is mapped onto collective atomic excitations on an optical transition and
stored for a pre-programmed time up of to 1 mu s before being released in a
well defined spatio-temporal mode as a result of a collective interference. The
coherence of the process is verified by performing an interference experiment
with two stored weak pulses with a variable phase relation. Visibilities of
more than 95% are obtained, which demonstrates the high coherence of the
mapping process at the single photon level. In addition, we show experimentally
that our interface allows one to store and retrieve light fields in multiple
temporal modes. Our results represent the first observation of collective
enhancement at the single photon level in a solid and open the way to multimode
solid state quantum memories as a promising alternative to atomic gases.Comment: 5 pages, 5 figures, version submitted on June 27 200
Shot noise in normal metal-d-wave superconducting junctions
We present theoretical calculations and predictions for the shot noise in
voltage biased junctions of superconductors and normal metal
counter-electrodes. In the clean limit for the d-wave superconductor the shot
noise vanishes at zero voltage because of resonant Andreev reflection by
zero-energy surface bound states. We examine the sensitivity of this resonance
to impurity scattering. We report theoretical results for the magnetic field
dependence of the shot noise, as well the fingerprints of subdominant - and
pairing channels.Comment: 15 pages, 8 figures and 3 tables embedde
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