The Spirit Moves

The Charismatic Movement represents one of the most significant developments in the life of the Church today. During the past decade and a half it has rapidly spread through the “mainline” denominational churches. As a result, a great deal of misunderstanding and tension has developed. Everything from devil worship to divisions in the Church has been attributed to the Holy Spirit Movement. Since there is much misunderstanding, prejudice and ignorance about the Holy Spirit Movement and the Holy Spirit moving, the following is presented which centres attention on the Biblical basis for this movement

Scattering matrices and expansion coefficients of Martian analogue palagonite particles

We present measurements of ratios of elements of the scattering matrix of Martian analogue palagonite particles for scattering angles ranging from 3 to 174 degrees and a wavelength of 632.8 nm. To facilitate the use of these measurements in radiative transfer calculations we have devised a method that enables us to obtain, from these measurements, a normalized synthetic scattering matrix covering the complete scattering angle range from 0 to 180 degrees. Our method is based on employing the coefficients of the expansions of scattering matrix elements into generalized spherical functions. The synthetic scattering matrix elements and/or the expansion coefficients obtained in this way, can be used to include multiple scattering by these irregularly shaped particles in (polarized) radiative transfer calculations, such as calculations of sunlight that is scattered in the dusty Martian atmosphere.Comment: 34 pages 7 figures 1 tabl

The dark days are overcast : iron-bearing clouds on HD 209458 b and WASP-43 b can explain low-dayside albedos

Funding; This project has received funding from STFC, under project number ST/V000861/1. Ch.H. and L.C. acknowledges funding from the European Union H2020-MSCA-ITN-2019 under grant agreement no. 860470 (CHAMELEON). K.L.C further acknowledges funding by UK Research and Innovation (UKRI) under the UK government’s Horizon Europe funding guarantee as part of an ERC Starter Grant [grant number EP/Y006313/1].We simulate the geometric albedo spectra of hot Jupiter exoplanets HD 209458 b and WASP-43 b, based on global climate model (GCMs) post-processed with kinetic cloud models. We predict WASP-43 b to be cloudy throughout its dayside, while HD 209458 b has a clear upper atmosphere around the hot sub-solar point, largely due to the inclusion of strong optical absorbers TiO and VO in the GCM for the latter causes a temperature inversion. In both cases our models find low geometric albedos - 0.026 for WASP-43b and 0.028 for HD 209458 b when averaged over the CHaracterizing ExOPlanet Satellite bandpass of ∼0.35 - 1.1 μm - indicating dark daysides, similar to the low albedos measured by observations. We demonstrate the strong impact of clouds that contain Fe-bearing species on the modelled geometric albedos; without Fe-bearing species forming in the clouds, the albedos of both planets would be much higher (0.518 for WASP-43 b, 1.37 for HD 209458 b). We conclude that a cloudy upper or mid-to-lower atmosphere that contains strongly absorbing Fe-bearing aerosol species, is an alternative to a cloud-free atmosphere in explaining the low dayside albedos of hot Jupiter atmospheres such as HD 209458 b and WASP-43 b.Peer reviewe

Slowing of oscillatory brain activity is a stable characteristic of Parkinson's disease without dementia

Extensive changes in resting-state oscillatory brain activity have recently been demonstrated using magnetoencephalography (MEG) in moderately advanced, non-demented Parkinson's disease patients relative to age-matched controls. The aim of the present study was to determine the onset and evolution of these changes over the disease course and their relationship with clinical parameters. In addition, we evaluated the effects of dopaminomimetics on resting-state oscillatory brain activity in levodopa-treated patients. MEG background oscillatory activity was studied in a group of 70 Parkinson's disease patients with varying disease duration and severity (including 18 de novo patients) as well as in 21 controls that were age-matched to the de novo patients. Whole head 151-channel MEG recordings were obtained in an eyes-closed resting-state condition. Levodopa-treated patients (N = 37) were examined both in a practically defined 'OFF' as well as in the 'ON' state. Relative spectral power was calculated for delta, theta, low alpha, high alpha, beta and gamma frequency bands and averaged for 10 cortical regions of interest (ROIs). Additionally, extensive clinical and neuropsychological testing was performed in all subjects. De novo Parkinson's disease patients showed widespread slowing of background MEG activity relative to controls. Changes included a widespread increase in theta and low alpha power, as well as a loss of beta power over all but the frontal ROIs and a loss of gamma power over all but the right occipital ROI. Neuropsychological assessment revealed abnormal perseveration in de novo patients, which was associated with increased low alpha power in centroparietal ROIs. In the whole group of Parkinson's disease patients, longer disease duration was associated with reduced low alpha power in the right temporal and right occipital ROI, but not with any other spectral power measure. No association was found between spectral power and disease stage, disease severity or dose of dopaminomimetics. In patients on levodopa therapy, a change from the 'OFF' to the 'ON' state was associated with decreases in right frontal theta, left occipital beta and left temporal gamma power and an increase in right parietal gamma power. Widespread slowing of oscillatory brain activity is a characteristic of non-demented Parkinson's disease patients from the earliest clinical stages onwards that is (largely) independent of disease duration, stage and severity and hardly influenced by dopaminomimetic treatment. Some early cognitive deficits in Parkinson's disease appear to be associated with increased low alpha power. We postulate a role for hypofunctional non-dopaminergic ascending neurotransmitter systems in spectral power changes in non-demented Parkinson's disease patients. © The Author (2007). Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved

Reduced Toxicity Conditioning with Busulfan, Fludarabine, Alemtuzumab and Allogeneic Stem Cell Transplantation From HLA-Matched Sibling Donors in Children with High Risk Sickle Cell Disease Results in Long Term Donor Chimerism and Low Incidence of aGVHD

Purpose It is still equivocal whether oxygen uptake recovery kinetics are limited by oxygen delivery and can be improved by supplementary oxygen. The present study aimed to investigate whether measurements of muscle and pulmonary oxygen uptake kinetics can be used to assess oxygen delivery limitations in healthy subjects. Methods Sixteen healthy young adults performed three sub-maximal exercise tests (6 min at 40% Wmax) under hypoxic (14%O2), normoxic (21%O2) and hyperoxic (35%O2) conditions on separate days in randomized order. Both Pulmonary VO2 and near infra red spectroscopy (NIRS) based Tissue Saturation Index (TSI) offset kinetics were calculated using mono-exponential curve fitting models. Results Time constant τ of VO2 offset kinetics under hypoxic (44.9 ± 7.3s) conditions were significantly larger than τ of the offset kinetics under normoxia (37.9 ± 8.2s, p = 0.02) and hyperoxia (37±6s, p = 0.04). TSI mean response time (MRT) of the offset kinetics under hypoxic conditions (25.5 ± 13s) was significantly slower than under normoxic (15 ± 7.7, p = 0.007) and hyperoxic (13 ± 7.3, p = 0.008) conditions. Conclusion The present study shows that there was no improvement in the oxygen uptake and muscle oxygenation recovery kinetics in healthy subjects under hyperoxic conditions. Slower TSI and VO2 recovery kinetics under hypoxic conditions indicate that both NIRS and spiro-ergometry are appropriate non-invasive measurement tools to assess the physiological response of a healthy individual to hypoxic exercise

Serological markers of gluten sensitivity in Border terriers with gall bladder mucocoeles

Objectives To evaluate serological markers of gluten sensitivity in conjunction with cholecystokinin measurement in Border terriers with gall bladder mucocoeles. Materials and Methods Medical records from two referral hospitals were obtained between 2011 and 2019 to identify Border terriers with gall bladder mucocoeles, non‐Border terriers with gall bladder mucocoeles and control Border terriers with non‐biliary diseases. Enzyme‐linked immunosorbent assays were performed on stored fasted serum samples for anti‐gliadin IgG, anti‐canine transglutaminase‐2‐IgA autoantibodies and cholecystokinin. Statistical analysis was performed using the Kruskall‐Wallis test to identify differences between the groups. Results Fifteen Border terriers with gall bladder mucocoeles, 17 non‐Border terriers with gall bladder mucocoeles and 14 control Border terriers with non‐biliary diseases were recruited. Median transglutaminase‐2‐IgA autoantibodies in Border terriers with gall bladder mucocoeles was 0.73 (range: 0.18 to 1.67), which was significantly greater than in control Border terriers at 0.41 (0.07 to 1.14). Median cholecystokinin concentration in Border terriers with gall bladder mucocoeles was 13 pg/mL (6 to 45 pg/mL), which was significantly lower than in control Border terriers at 103 pg/mL (9 to 397 pg/mL). There was no difference in the anti‐gliadin IgG between these groups. There was no difference observed in the non‐Border terriers with gall bladder mucocoeles with either of the other groups. Clinical Significance Reduced cholecystokinin and increased transglutaminase‐2‐IgA autoantibodies was detected in Border terriers with gall bladder mucocoeles; which is in part homologous to gall bladder disease identified in human coeliac disease. The results suggest an immunological disease with impaired cholecystokinin release may be affecting gall bladder motility and possibly contributing to mucocoele formation in Border terriers

Modelling reflected polarized light from close-in giant exoplanet WASP-96b using PolHEx (Polarisation of hot exoplanets)

Funding: This project has received funding from STFC, under project number ST/V000861/1. ChH further acknowledges funding from the European Union H2020-MSCA-ITN-2019 under grant agreement number 860470 (CHAMELEON). DS acknowledge financial support from the Austrian Academy of Sciences.We present the Polarisation of Hot Exoplanets (PolHEx) code for modelling the total flux (F) and degree of linear polarisation (P) of light spectra reflected by close-in, tidally locked exoplanets. We use the output from a global climate model (GCM) combined with a kinetic cloud model of hot Jupiter WASP-96b as a base to investigate effects of atmospheric longitudinal-latitudinal inhomogeneities on these spectra. We model F and P-spectra as functions of wavelength and planet orbital phase for various model atmospheres. We find different materials and sizes of cloud particles to impact the reflected flux F, and particularly the linear polarisation state P. A range of materials are used to form inhomogeneous mixed-material cloud particles (Al2O3, Fe2O3, Fe2SiO4, FeO, Fe, Mg2SiO4, MgO, MgSiO3, SiO2, SiO, TiO2), with Fe2O3, Fe, and FeO the most strongly absorbing species. The cloud particles near the relatively cool morning terminator are expected to have smaller average sizes and a narrower size distribution than those near the warmer evening terminator, which leads to different reflected spectra at the respective orbital phases. We also find differences in the spectra of F and P as functions of orbital phase for irregularly or spherically shaped cloud particles. This work highlights the importance of including polarisation in models and future observations of the reflection spectra of exoplanets.Publisher PDFPeer reviewe