Geographic proximity and firm-university innovation linkages: evidence from Great Britain

We investigate evidence for spatially mediated knowledge transfer from university research. We examine whether firms locate their R&D labs near universities, and whether those that do are more likely to co-operate with, or source knowledge from universities. We find that pharmaceutical firms locate R&D near to frontier chemistry research departments, consistent with accessing localised knowledge spillovers, but also linked to the presence of science parks. In industries such as chemicals and vehicles there is less evidence of immediate co-location, but those innovative firms that do locate near to relevant research departments are more likely to engage with universities

An experimental study of the properties of surface pressure fluctuations in strong adverse pressure gradient turbulent boundary layers

Experimental data were obtained on blade self-noise generation by strong adverse-pressure-gradient attached boundary layers and by separated turbulent boundary layers that accompany stall. Two microphones were calibrated, placed in plastic housing, and installed in a wind tunnel where observations of acoustic and turbulent signals permitted decomposition of the surface pressure fluctuation signals into the propagated acoustic part and the turbulent-flow generated portion. To determine the convective wave speed of the turbulent contributions, the microphones were spaced a small distance apart in the streamwise direction and correlations were obtained. The turbulent surface pressure spectra upstream of detachment and downstream of the beginning of separation are discussed as well as measurements of turbulent velocity spectra and wavespeeds

Experimental measurements of unsteady turbulent boundary layers near separation

Investigations conducted to document the behavior of turbulent boundary layers on flat surfaces that separate due to adverse pressure gradients are reported. Laser and hot wire anemometers measured turbulence and flow structure of a steady free stream separating turbulent boundary layer produced on the flow of a wind tunnel section. The effects of sinusoidal and unsteadiness of the free stream velocity on this separating turbulent boundary layer at a reduced frequency were determined. A friction gage and a thermal tuft were developed and used to measure the surface skin friction and the near wall fraction of time the flow moves downstream for several cases. Abstracts are provided of several articles which discuss the effects of the periodic free stream unsteadiness on the structure or separating turbulent boundary layers

An experimental study of the properties of surface pressure fluctuations for separating turbulent boundary layers

Noise generated by helicopter and turbomachine rotors is a nuisance that designers would like to predict and to minimize within other design constraints. A key element for the noise calculation procedure is knowledge relating the flowfield structure to the surface pressure fluctuation structure. Surface pressure fluctuation data for zero-pressure-gradient and accelerating turbulent boundary layers were obtained. The zero-pressure-gradient turbulent boundary layers were examined with freestream velocities of 72 and 105 fps. Mean and fluctuation velocity profiles and streamwise velocity spectra and wavespeeds were obtained for momentum thickness Reynolds numbers up to 18000 for the zero-pressure-gradient case and up to 4000 for the favorable-pressure-gradient case. The wall shearing stress was estimated from a Clauser plot of the near wall data. It is clear that turbulent pressure fluctuations are produced by turbulent velocity fluctuations. Detailed simultaneous measurements of all of these fluctuations are needed to determine in more detail the structural relationships between velocity and pressure fields. Although some measurements were made for unseparated flows, none were made for separated flows

Modelling & Improving Flow Establishment in RSVP

RSVP has developed as a key component for the evolving Internet, and in particular for the Integrated Services Architecture. Therefore, RSVP performance is crucially important; yet this has been little studied up till now. In this paper, we target one of the most important aspects of RSVP: its ability to establish flows. We first identify the factors influencing the performance of the protocol by modelling the establishment mechanism. Then, we propose a Fast Establishment Mechanism (FEM) aimed at speeding up the set-up procedure in RSVP. We analyse FEM by means of simulation, and show that it offers improvements to the performance of RSVP over a range of likely circumstances

Investigation of blown boundary layers with an improved wall jet system

The behavior of two dimensional incompressible turbulent wall jets submerged in a boundary layer when they are used to prevent boundary layer separation on plane surfaces is investigated. The experimental set-up and instrumentation are described. Experimental results of zero pressure gradient flow and adverse pressure gradient flow are presented. Conclusions are given and discussed

Leishmania tarentolae: taxonomic classification and its application as a promising biotechnological expression host

In this review, we summarize the current knowledge concerning the eukaryotic protozoan parasite Leishmania tarentolae, with a main focus on its potential for biotechnological applications. We will also discuss the genus, subgenus, and species-level classification of this parasite, its life cycle and geographical distribution, and similarities and differences to human-pathogenic species, as these aspects are relevant for the evaluation of biosafety aspects of L. tarentolae as host for recombinant DNA/protein applications. Studies indicate that strain LEM-125 but not strain TARII/UC of L. tarentolae might also be capable of infecting mammals, at least transiently. This could raise the question of whether the current biosafety level of this strain should be reevaluated. In addition, we will summarize the current state of biotechnological research involving L. tarentolae and explain why this eukaryotic parasite is an advantageous and promising human recombinant protein expression host. This summary includes overall biotechnological applications, insights into its protein expression machinery (especially on glycoprotein and antibody fragment expression), available expression vectors, cell culture conditions, and its potential as an immunotherapy agent for human leishmaniasis treatment. Furthermore, we will highlight useful online tools and, finally, discuss possible future applications such as the humanization of the glycosylation profile of L. tarentolae or the expression of mammalian recombinant proteins in amastigotelike cells of this species or in amastigotes of avirulent human-pathogenic Leishmania species