Variations in seasonal solar insolation are associated with a history of suicide attempts in bipolar I disorder

Background: Bipolar disorder is associated with circadian disruption and a high risk of suicidal behavior. In a previous exploratory study of patients with bipolar I disorder, we found that a history of suicide attempts was associated with differences between winter and summer levels of solar insolation. The purpose of this study was to confirm this finding using international data from 42% more collection sites and 25% more countries. Methods: Data analyzed were from 71 prior and new collection sites in 40 countries at a wide range of latitudes. The analysis included 4876 patients with bipolar I disorder, 45% more data than previously analyzed. Of the patients, 1496 (30.7%) had a history of suicide attempt. Solar insolation data, the amount of the sun’s electromagnetic energy striking the surface of the earth, was obtained for each onset location (479 locations in 64 countries). Results: This analysis confirmed the results of the exploratory study with the same best model and slightly better statistical significance. There was a significant inverse association between a history of suicide attempts and the ratio of mean winter insolation to mean summer insolation (mean winter insolation/mean summer insolation). This ratio is largest near the equator which has little change in solar insolation over the year, and smallest near the poles where the winter insolation is very small compared to the summer insolation. Other variables in the model associated with an increased risk of suicide attempts were a history of alcohol or substance abuse, female gender, and younger birth cohort. The winter/summer insolation ratio was also replaced with the ratio of minimum mean monthly insolation to the maximum mean monthly insolation to accommodate insolation patterns in the tropics, and nearly identical results were found. All estimated coefficients were significant at p < 0.01. Conclusion: A large change in solar insolation, both between winter and summer and between the minimum and maximum monthly values, may increase the risk of suicide attempts in bipolar I disorder. With frequent circadian rhythm dysfunction and suicidal behavior in bipolar disorder, greater understanding of the optimal roles of daylight and electric lighting in circadian entrainment is needed

Exploratory study of ultraviolet B (UVB) radiation and age of onset of bipolar disorder

Background: Sunlight contains ultraviolet B (UVB) radiation that triggers the production of vitamin D by skin. Vitamin D has widespread effects on brain function in both developing and adult brains. However, many people live at latitudes (about > 40 N or S) that do not receive enough UVB in winter to produce vitamin D. This exploratory study investigated the association between the age of onset of bipolar I disorder and the threshold for UVB sufficient for vitamin D production in a large global sample. Methods: Data for 6972 patients with bipolar I disorder were obtained at 75 collection sites in 41 countries in both hemispheres. The best model to assess the relation between the threshold for UVB sufficient for vitamin D production and age of onset included 1 or more months below the threshold, family history of mood disorders, and birth cohort. All coefficients estimated at P ≤ 0.001. Results: The 6972 patients had an onset in 582 locations in 70 countries, with a mean age of onset of 25.6 years. Of the onset locations, 34.0% had at least 1 month below the threshold for UVB sufficient for vitamin D production. The age of onset at locations with 1 or more months of less than or equal to the threshold for UVB was 1.66 years younger. Conclusion: UVB and vitamin D may have an important influence on the development of bipolar disorder. Study limitations included a lack of data on patient vitamin D levels, lifestyles, or supplement use. More study of the impacts of UVB and vitamin D in bipolar disorder is needed to evaluate this supposition

Association between solar insolation and a history of suicide attempts in bipolar I disorder

In many international studies, rates of completed suicide and suicide attempts have a seasonal pattern that peaks in spring or summer. This exploratory study investigated the association between solar insolation and a history of suicide attempt in patients with bipolar I disorder. Solar insolation is the amount of electromagnetic energy from the Sun striking a surface area on Earth. Data were collected previously from 5536 patients with bipolar I disorder at 50 collection sites in 32 countries at a wide range of latitudes in both hemispheres. Suicide related data were available for 3365 patients from 310 onset locations in 51 countries. 1047 (31.1%) had a history of suicide attempt. There was a significant inverse association between a history of suicide attempt and the ratio of mean winter solar insolation/mean summer solar insolation. This ratio is smallest near the poles where the winter insolation is very small compared to the summer insolation. This ratio is largest near the equator where there is relatively little variation in the insolation over the year. Other variables in the model that were positively associated with suicide attempt were being female, a history of alcohol or substance abuse, and being in a younger birth cohort. Living in a country with a state-sponsored religion decreased the association. (All estimated coefficients p <0.01). In summary, living in locations with large changes in solar insolation between winter and summer may be associated with increased suicide attempts in patients with bipolar disorder. Further investigation of the impacts of solar insolation on the course of bipolar disorder is needed.Peer reviewe

Role of non-wood forest products for local livelihoods in countries with transition and market economies: case studies in Ukraine and Sweden

The role of non-wood forest products (NWFPs) in local economies differ in time and space. We analysed Ukrainian and Swedish national policies and management rules related to the use of NWFPs, and described how different forest stakeholders utilised NWFPs in rural areas in Ukraine and Sweden. In total we interviewed 114 local forest stakeholders in one rural region’s settlements in both countries. The topics for the field study were (1) the reasons and amounts of NWFPs harvested by different forest user categories; (2) traditional practices of NWFP use, including harvesting methods and (3) how these practices have changed over the past decades. At the national level, both countries allowed the utilisation of most NWFPs, did not regulate the use, and did not include NWFPs into forest management plans. In both case studies, historical use of NWFPs was intensive. This use remained important in Ukraine, but not in Sweden. Due to difficult economic transition in Ukraine, use of NWFPs by locals has increased. While hunting as a tradition was more popular in the Swedish case study, recreational use of forest was popular in both case studies. Finally, we discuss the role of NWFPs in countries with transition and market economies, and the extent to which the countries support sustainable use of NWFPs

South Atlantic Transect: Variations in Oceanic Crustal Structure at 31°S

Abstract We present an analysis of geophysical data acquired along a transect of 0–62 Ma crust located on the western flank of the Mid‐Atlantic Ridge at 31°S; all crust was formed at the same ridge segment. Crustal thickness, constrained by five wide‐angle profiles, has mean values of 5.6 km at 6.6 and 15.2 Ma, 7.0 km at 30.6 Ma, 5.5 km at 49.2 Ma, and 3.6 km at 61.2 Ma. Crustal thickness is uniform along each ridge‐parallel profile (standard deviations 0.1–0.3 km), indicating uniform along‐axis magmatic accretion over lateral distances of 40–60 km. The crustal structure of 61.2 Ma crust is not only anomalously thin compared to the other profiles but also contains regions with a linear velocity gradient from seafloor to Moho, which suggests that intense fracturing may extend to the base of the thin crust. Abyssal hill root‐mean‐square heights in the study region are 57–142 m and have an inverse correlation with spreading rate. These values are lower than the average root‐mean‐square height of 196 m elsewhere on the southern Mid‐Atlantic Ridge and indicate relatively high mantle temperatures in our study area. Unsedimented or lightly sedimented basement highs are prevalent at all ages; we argue that bottom currents scour the high topography, transporting sediment into adjacent basement lows. All drillsites planned for International Ocean Discovery Program Expeditions 390 and 393 are within 1–10 km of unsedimented or lightly sedimented basement highs, which should facilitate fluid flow and continued geochemical exchange between crust and seafloor