A Computational Complexity Theory in Membrane Computing

In this paper, a computational complexity theory within the framework of Membrane Computing is introduced. Polynomial complexity classes associated with di erent models of cell-like and tissue-like membrane systems are de ned and the most relevant results obtained so far are presented. Many attractive characterizations of P 6= NP conjecture within the framework of a bio-inspired and non-conventional computing model are deduced.Ministerio de Educación y Ciencia TIN2006-13425Junta de Andalucía P08–TIC-0420

Estimación de la pérdida de producción de leche en relación con el recuento de células somáticas de leche de tanque

publishedTomo I . Sección: Sistemas Ganaderos-Economía y Gestión. Sesión: Economía II. Ponencia nº 2

Design Patterns for Efficient Solutions to NP-Complete Problems in Membrane Computing

Many variants of P systems have the ability to generate an exponential number of membranes in linear time. This feature has been exploited to elaborate (theoretical) efficient solutions to NP-complete, or even harder, problems. A thorough review of the existent solutions shows the utilization of common techniques and procedures. The abstraction of the latter into design patterns can serve to ease and accelerate the construction of efficient solutions to new hard problems.Ministerio de Economía y Competitividad TIN2017-89842-

KBE Application for the Design and Manufacture of HSM Fixtures

The design of machining fixtures for aeronautical parts is strongly based in the knowledge of the fixture designer, and it comprises certain repetitive tasks. An analysis of the design process allows us to state its suitability for developing Knowledge Based Engineering (KBE) applications in order to capture the knowledge, and to systematize and automate the designs.This work justifies the importance of fixtures for High Speed Milling (HSM), and explains the development of a KBE application to automate the design and manufacturing of such elements. The application is the outcome of a project carried out in collaboration with the company EADS.In the development process, a specific methodology was used in order to represent the knowledge in a semi-structured way and to document the information needed to define the system. The developed KBE application is independent of the parts design system. This makes it necessary to use an interface to input the part geometry into the KBE application, where it is analyzed in order to extract the relevant information for the fixture design process. The results obtained from the application come in three different ways: raw material drawings, fixture 3D solid models, and text files (Bill Of Materials – BOM, and Numerical Control – NC programs). All the results are exported to other applications for use in other tasks. The designer interacts with the application through an ad hoc interface, where he is asked to select or input some data and where the results are also visualized. The prototype KBE application has been carried out in the ICAD development environment and the main interface is with the CAD/CAM system CATIA V4.

BN 52021 (a platelet activating factor-receptor antagonist) decreases alveolar macrophage-mediated lung injury in experimental extrinsic allergic alveolitis.

Several lines of research indirectly suggest that platelet activating factor (PAF) may intervene in the pathogenesis of extrinsic allergic alveolitis (EAA). The specific aim of our study was to evaluate the participation of PAF on macrophage activation during the acute phase of EAA in an experimental model of this disease developed in guinea pigs. Initially we measured the concentration of PAF in bronchoalvedar lavage fluid, blood and lung tissue. In a second phase we evaluate the participation of PAF on alveolar macrophage activation and parenchymal lung injury. The effect of PAF on parenchymal lung injury was evaluated by measuring several lung parenchymatous lesion indices (lung index, bronchoalvedar lavage fluid (BALF) lactic hydrogenase activity and BALF alkaline phosphatase activity) and parameters of systemic response to the challenge (acute phase reagents). We observed that induction of the experimental EAA gave rise to an increase in the concentration of PAF in blood and in lung tissue. The use of the PAF-receptor antagonist BN52021 decreases the release of lysosomal enzymes (beta-glucuronidase and tartrate-sensitive acid phosphatase) to the extracellular environment both in vivo and in vitro. Furthermore, antagonism of the PAF receptors notably decreases pulmonary parenchymatous lesion. These data suggest that lung lesions from acute EAA are partly mediated by local production of PAF

Determinación de mecanismos de deslizamientosa en áreas urbanizadas de la Sierra de las Apretaderas, término de Alcuzcuz, Benahavís, Málaga

La naturaleza intrínseca del material mantiene una estrecha relación con el tipo de inestabilidad. El trabajo recoge la experiencia en la determinación de mecanismo de deslizamientos en el área de la Sierra de Las Apretaderas, término de Alcuzcuz, en Benahavís, Málaga. La intensa urbanización de amplias áreas serranas conlleva la transformación del medio a través de la construcción de infraestructuras de comunicación y extensas áreas residenciales y la interacción de dichas construcciones con el medio provoca a menudo el desencadenamiento de siniestros relacionados con los deslizamientos de ladera en ocasiones poco sospechosos. El trabajo que se presenta recoge la experiencia de un siniestro acaecido bajo estas circunstancias y provocando numerosos daños materiales en edificaciones de lujo e infraestructuras anejas

Role of lysosomal enzymes released by alveolar macrophages in the pathogenesis of the acute phase of hypersensitivity pneumonitis

Hydrolytic enzymes are the major constituents of alveolar macrophages (AM) and have been shown to be involved in many aspects of the inflammatory pulmonary response. The aim of this study was to evaluate the role of lysosomal enzymes in the acute phase of hypersensitivity pneumonitis (HPs). An experimental study on AM lysosomal enzymes of an HP-guinea-pig model was performed. The results obtained both in vivo and in vitro suggest that intracellular enzymatic activity decrease is, at least partly, due to release of lysosomal enzymes into the medium. A positive but slight correlation was found between extracellular lysosomal activity and four parameters of lung lesion (lung index, bronchoalveolar fluid total (BALF) protein concentration, BALF LDH and BALF alkaline phosphatase activities). All the above findings suggest that the AM release of lysosomal enzymes during HP is a factor involved, although possibly not the only one, in the pulmonary lesions appearing in this disease