Material Characterization at High Strain Rates with Special Emphasis on Miniaturization and Size Dependencies

Within the present work the size-dependent flow stress and failure behaviour of various metallic materials is described. Starting with special issues of testing miniaturized specimens, the influence of manufacturing routes and manufacturing induced geometrical deviations is investigated. The specimen size and time-dependent flow stress behavior of C45E, Ti-6-22-22S, and Al7075T6 is presented. The measured behavior is explained by size-dependent friction effects. Additionally, the influence of size and time scaling on the occurring of failure is investigated. A decrease of compressive deformability with increasing size and strain rate was found. The consideration of a size-dependent thermodynamic process character provides a possible explanation for measured size dependencies

The vertical distribution of zooplankton in the Goggausee (the influence of algae and Chaoborus flavicans) [Translation from: Carinthia II 166/186 373-385, 1976]

The Goggausee, a small, shallow, meromictic lake(700m long, 150m wide, max. depth=12m, mean depth=6m), was the site of a week long study (19-26 May 1974) of the limnology department of the University of Vienna. The study comprised pollen analysis and palaeolimnological studies on the one hand, as well as a stock- taking of physiochemical factors, primary production, bacteria, zooplankton, zoo benthos and fish on the other. This paper studies the zooplankton of the lake. The Goggausee is a meromictic lake, with its anoxic deep water, that restricts the vertical distribution of most zooplankton. The aim of the study was to pursue the vertical distribution of the rotifers and Crustacea. Density of individuals, biomass, percentages of zooplankton together and crustaceans and rotifers as groups. Special consideration is given to the the Dipteran Chaoborus flavicans

Genomic organization and classification of the bovine WC1 genes and expression by peripheral blood gamma delta T cells

Background: WC1 co-receptors are group B scavenger receptor cysteine-rich molecules that are found exclusively on γδT cells and are thought to be encoded by a multi-gene family. Previous studies have shown γδT cells that respond to a particular stimulus have unique WC1 molecules expressed. Prior to the onset of the studies described here only one full-length WC1 nucleotide sequence was publicly available, though three WC1 molecules had been distinguished based on monoclonal antibody reactivity. Furthermore, the number of WC1 genes found in the bovine genome and their sequences had not yet been resolved. Results: By annotating the bovine genome Btau_3.1 assembly, here we show the existence of 13 members in the WC1 gene family and their organization within two loci on chromosome 5 including three distinct exon-intron gene structures one of which coded for a potentially more primitive and smaller WC1 molecule that is similar to the swine WC1 gene. We also provide cDNA evidence as verification for many of the annotated sequences and show transcripts for isoforms derived by alternative splicing. Conclusion: It is possible that WC1 diversity contributes to functional differences that have been observed between γδT cell populations. The studies described here demonstrate that WC1 molecules are encoded by a large, multi-gene family whose transcripts undergo extensive alternative splicing. Similar to other non-rearranging immunoreceptors, it is likely that the WC1 gene repertoire underwent expansion in order to keep pace with rapidly changing ligands

General practitioners can evaluate the material, social and health dimensions of patient social status

OBJECTIVE: To identify which physician and patient characteristics are associated with physicians' estimation of their patient social status.DESIGN: Cross-sectional ulticentric survey. SETTING: Fourty-seven primary care private offices in Western Switzerland. PARTICIPANTS: Random sample of 2030 patients ≥ 16, who encountered a general practitioner (GP) between September 2010 and February 2011. MAIN MEASURES: PRIMARY OUTCOME: patient social status perceived by GPs, using the MacArthur Scale of Subjective Social Status, ranging from the bottom (0) to the top (10) of the social scale.Secondary outcome: Difference between GP's evaluation and patient's own evaluation of their social status. Potential patient correlates: material and social deprivation using the DiPCare-Q, health status using the EQ-5D, sources of income, and level of education. GP characteristics: opinion regarding patients' deprivation and its influence on health and care. RESULTS: To evaluate patient social status, GPs considered the material, social, and health aspects of deprivation, along with education level, and amount and type of income. GPs declaring a frequent reflexive consideration of their own prejudice towards deprived patients, gave a higher estimation of patients' social status (+1.0, p = 0.002). Choosing a less costly treatment for deprived patients was associated with a lower estimation (-0.7, p = 0.002). GP's evaluation of patient social status was 0.5 point higher than the patient's own estimate (p<0.0001). CONCLUSIONS: GPs can perceive the various dimensions of patient social status, although heterogeneously, according partly to their own characteristics. Compared to patients' own evaluation, GPs overestimate patient social status

The classification of irreducible admissible mod p representations of a p-adic GL_n

Let F be a finite extension of Q_p. Using the mod p Satake transform, we define what it means for an irreducible admissible smooth representation of an F-split p-adic reductive group over \bar F_p to be supersingular. We then give the classification of irreducible admissible smooth GL_n(F)-representations over \bar F_p in terms of supersingular representations. As a consequence we deduce that supersingular is the same as supercuspidal. These results generalise the work of Barthel-Livne for n = 2. For general split reductive groups we obtain similar results under stronger hypotheses.Comment: 55 pages, to appear in Inventiones Mathematica

Annotation and classification of the bovine T cell receptor delta genes

Abstract Background: gδ T cells differ from ab T cells with regard to the types of antigen with which their T cell receptors interact; gδ T cell antigens are not necessarily peptides nor are they presented on MHC. Cattle are considered a “gδ T cell high” species indicating they have an increased proportion of gδ T cells in circulation relative to that in “gδ T cell low” species such as humans and mice. Prior to the onset of the studies described here, there was limited information regarding the genes that code for the T cell receptor delta chains of this gδ T cell high species. Results: By annotating the bovine (Bos taurus) genome Btau_3.1 assembly the presence of 56 distinct T cell receptor delta (TRD) variable (V) genes were found, 52 of which belong to the TRDV1 subgroup and were comingled with the T cell receptor alpha variable (TRAV) genes. In addition, two genes belonging to the TRDV2 subgroup and single TRDV3 and TRDV4 genes were found. We confirmed the presence of five diversity (D) genes, three junctional (J) genes and a single constant (C) gene and describe the organization of the TRD locus. The TRDV4 gene is found downstream of the C gene and in an inverted orientation of transcription, consistent with its orthologs in humans and mice. cDNA evidence was assessed to validate expression of the variable genes and showed that one to five D genes could be incorporated into a single transcript. Finally, we grouped the bovine and ovine TRDV1 genes into sets based on their relatedness. Conclusions: The bovine genome contains a large and diverse repertoire of TRD genes when compared to the genomes of “gδ T cell low” species. This suggests that in cattle gδ T cells play a more important role in immune function since they would be predicted to bind a greater variety of antigens

Granular jamming based controllable organ design for abdominal palpation

Medical manikins play an essential role in the training process of physicians. Currently, most available simulators for abdominal palpation training do not contain controllable organs for dynamic simulations. In this paper, we present a soft robotics controllable liver that can simulate various liver diseases and symptoms for effective and realistic palpation training. The tumors in the liver model are designed based on granular jamming with positive pressure, which converts the fluid-like impalpable particles to a solid-like tumor state by applying low positive pressure on the membrane. Through inflation, the tumor size, liver stiffness, and liver size can be controlled from normal liver state to various abnormalities including enlarged liver, cirrhotic liver, and multiple cancerous and malignant tumors. Mechanical tests have been conducted in the study to evaluate the liver design and the role of positive pressure granular jamming in tumor simulations

Weight and Body Image Perceptions in Nutrition and Dietetics University Students

Stereotypical and prejudicial attitudes towards people considered overweight or obese are documented in professionals ranging from physicians, nurses, fitness and general nutrition professionals, and registered dietitian nutritionists (RDN) and may introduce barriers to equitable care. To identify the prevalence of anti-fat attitudes (AFA); fat phobia (FPS); and body appreciation scores (BA) in nutrition and dietetics’ students (ND) and non-nutrition and dietetics’ students (NND) through a cross-sectional design. During 2018, students (n=297) from two California State Universities completed a survey including three validated instruments. Additionally, height, weight, and waist circumference were collected using NHANES procedures. A series of ANCOVA’s and correlation coefficients were computed. Significant differences existed in BA between ND (M=3.61, SD=0.66) and NND students (M=3.81, SD=0.70); t(288) = 2.49, p=0.013. Scores indicated existing anti-fat attitudes and fat phobia. Significant positive correlations existed between FPS and anthropometrics. Weight related perceptions were identified. A need exists for a fundamental evidence-based training specifically focused on knowledge and awareness related to health metrics and social justice pedagogy to help RDN work unbiasedly with patients of all shapes

Instruments for investigating fitness to drive - needs and expectations in primary care: a qualitative study

Background: Primary care physicians are often requested to assess their patients' fitness to drive. Little is however known on their needs to help them in this task. Aims: The aim of this study is to develop theories on needs, expectations, and barriers for clinical instruments helping physicians assess fitness to drive in primary care. Methods: This qualitative study used semi-structured interviews to investigate needs and expectations for instruments used to assess fitness to drive. From August 2011 to April 2013, we recorded opinions from five experts in traffic medicine, five primary care physicians, and five senior drivers. All interviews were integrally transcribed. Two independent researchers extracted, coded, and stratified categories relying on multi-grounded theory. All participants validated the final scheme. Results: Our theory suggests that for an instruments assessing fitness to drive to be implemented in primary care, it need to contribute to the decisional process. This requires at least five conditions: 1) it needs to reduce the range of uncertainty, 2) it needs to be adapted to local resources and possibilities, 3) it needs to be accepted by patients, 4) choices of tasks need to adaptable to clinical conditions, 5) and interpretation of results need to remain dependant of each patient's context. Discussion and conclusions: Most existing instruments assessing fitness to drive are not designed for primary care settings. Future instruments should also aim to support patient-centred dialogue, help anticipate driving cessation, and offer patients the opportunity to freely take their own decision on driving cessation as often as possible