The Use of Multi-beam Sonars to Image Bubbly Ship Wakes

During the past five years, researchers at Penn State University (PSU) have used upward-looking multi-beam (MB) sonar to image the bubbly wakes of surface ships. In 2000, a 19-beam, 5° beam width, 120° sector, 250 kHz MB sonar integrated into an autonomous vehicle was used to obtain a first-of-a-kind look at the three-dimensional variability of bubbles in a large ship wake. In 2001 we acquired a Reson 8101 MB sonar, which operates at 240 kHz and features 101-1.5º beams spanning a 150º sector. In July 2002, the Reson sonar was deployed looking upward from a 1.4 m diameter buoy moored at 29.5 m depth in 550 m of water using three anchor lines. A fiber optic cable connected the sonar to a support ship 500 m away. Images of the wake of a small research vessel provided new information about the persistence of bubble clouds in the ocean. An important goal is to use the MB sonar to estimate wake bubble distributions, as has been done with single beam sonar. Here we show that multipath interference and strong, specular reflections from the sea surface adversely affect the use of MB sonars to unambiguously estimate wake bubble distributio

Evaluation of rigid registration methods for whole head imaging in diffuse optical tomography

Functional brain imaging has become an important neuroimaging technique for the study of brain organization and development. Compared to other imaging techniques, diffuse optical tomography (DOT) is a portable and low-cost technique that can be applied to infants and hospitalized patients using an atlas-based light model. For DOT imaging, the accuracy of the forward model has a direct effect on the resulting recovered brain function within a field of view and so the accuracy of the spatially normalized atlas-based forward models must be evaluated. Herein, the accuracy of atlas-based DOT is evaluated on models that are spatially normalized via a number of different rigid registration methods on 24 subjects. A multileveled approach is developed to evaluate the correlation of the geometrical and sensitivity accuracies across the full field of view as well as within specific functional subregions. Results demonstrate that different registration methods are optimal for recovery of different sets of functional brain regions. However, the “nearest point to point” registration method, based on the EEG 19 landmark system, is shown to be the most appropriate registration method for image quality throughout the field of view of the high-density cap that covers the whole of the optically accessible cortex

IgG4 autoantibodies and autoantigens in the context of IgG4-autoimmune disease and IgG4-related disease

Immunoglobulins are an essential part of the humoral immune response. IgG4 antibodies are the least prevalent subclass and have unique structural and functional properties. In this review, we discuss IgG4 class switch and B cell production. We review the importance of IgG4 antibodies in the context of allergic responses, helminth infections and malignancy. We discuss their anti-inflammatory and tolerogenic effects in allergen-specific immunotherapy, and ability to evade the immune system in parasitic infection and tumour cells. We then focus on the role of IgG4 autoantibodies and autoantigens in IgG4-autoimmune diseases and IgG4-related disease, highlighting important parallels and differences between them. In IgG4-autoimmune diseases, pathogenesis is based on a direct role of IgG4 antibodies binding to self-antigens and disturbing homeostasis. In IgG4-related disease, where affected organs are infiltrated with IgG4-expressing plasma cells, IgG4 antibodies may also directly target a number of self-antigens or be overexpressed as an epiphenomenon of the disease. These antigen-driven processes require critical T and B cell interaction. Lastly, we explore the current gaps in our knowledge and how these may be addressed

High-density speckle contrast optical tomography (SCOT) for three dimensional tomographic imaging of the small animal brain

High-density speckle contrast optical tomography (SCOT) utilizing tens of thousands of source-detector pairs, was developed for in vivo imaging of blood flow in small animals. The reduction in cerebral blood flow (CBF) due to local ischemic stroke in a mouse brain was transcanially imaged and reconstructed in three dimensions. The reconstructed volume was then compared with corresponding magnetic resonance images demonstrating that the volume of reduced CBF agrees with the infarct zone at twenty-four hours.Peer ReviewedPostprint (author's final draft

Validating the National Survey of Student Engagement (NSSE) at a Research-Intensive University

The National Survey of Student Engagement (NSSE) has been used at universities across the U.S. and Canada to gather information about the quality of engagement of first-year students and graduating students. Institutions use NSSE’s five benchmarks of effective educational practice to compare themselves with other schools and to focus in on ways to improve the educational experiences of their students. However, studies indicate that these benchmarks may not be a valid way to convey NSSE information. This study was conducted to investigate whether or not NSSE’s five-factor model is the best fit for student engagement data collected at a large, public, research-intensive, land-grant university. The five-factor model did not fit the data for the 2008 sample of senior students at this university. Rather, a revised model using six factors instead of five and 21 of 42 items provided a more valid test blueprint. This new model was then tested and found to fit the 2011 sample of senior students at the same university. Discussion regarding use of a nationally collected data at an individual institution is provided

IgG4 autoantibodies and autoantigens in the context of IgG4-autoimmune disease and IgG4-related disease

Immunoglobulins are an essential part of the humoral immune response. IgG4 antibodies are the least prevalent subclass and have unique structural and functional properties. In this review, we discuss IgG4 class switch and B cell production. We review the importance of IgG4 antibodies in the context of allergic responses, helminth infections and malignancy. We discuss their anti-inflammatory and tolerogenic effects in allergen-specific immunotherapy, and ability to evade the immune system in parasitic infection and tumour cells. We then focus on the role of IgG4 autoantibodies and autoantigens in IgG4-autoimmune diseases and IgG4-related disease, highlighting important parallels and differences between them. In IgG4-autoimmune diseases, pathogenesis is based on a direct role of IgG4 antibodies binding to self-antigens and disturbing homeostasis. In IgG4-related disease, where affected organs are infiltrated with IgG4-expressing plasma cells, IgG4 antibodies may also directly target a number of self-antigens or be overexpressed as an epiphenomenon of the disease. These antigen-driven processes require critical T and B cell interaction. Lastly, we explore the current gaps in our knowledge and how these may be addressed

GSFC Cutting Edge Avionics Technologies for Spacecraft

With the launch of NASA's first fiber optic bus on SAMPEX in 1992, GSFC has ushered in an era of new technology development and insertion into flight programs. Predating such programs the Lewis and Clark missions and the New Millenium Program, GSFC has spearheaded the drive to use cutting edge technologies on spacecraft for three reasons: to enable next generation Space and Earth Science, to shorten spacecraft development schedules, and to reduce the cost of NASA missions. The technologies developed have addressed three focus areas: standard interface components, high performance processing, and high-density packaging techniques enabling lower cost systems. To realize the benefits of standard interface components GSFC has developed and utilized radiation hardened/tolerant devices such as PCI target ASICs, Parallel Fiber Optic Data Bus terminals, MIL-STD-1773 and AS1773 transceivers, and Essential Services Node. High performance processing has been the focus of the Mongoose I and Mongoose V rad-hard 32-bit processor programs as well as the SMEX-Lite Computation Hub. High-density packaging techniques have resulted in 3-D stack DRAM packages and Chip-On-Board processes. Lower cost systems have been demonstrated by judiciously using all of our technology developments to enable "plug and play" scalable architectures. The paper will present a survey of development and insertion experiences for the above technologies, as well as future plans to enable more "better, faster, cheaper" spacecraft. Details of ongoing GSFC programs such as Ultra-Low Power electronics, Rad-Hard FPGAs, PCI master ASICs, and Next Generation Mongoose processors