Cartilage on the Move: Cartilage Lineage Tracing During Tadpole Metamorphosis

The reorganization of cranial cartilages during tadpole metamorphosis is a set of complex processes. The fates of larval cartilage-forming cells (chondrocytes) and sources of adult chondrocytes are largely unknown. Individual larval cranial cartilages may either degenerate or remodel, while many adult cartilages appear to form de novo during metamorphosis. Determining the extent to which adult chondrocytes/cartilages are derived from larval chondrocytes during metamorphosis requires new techniques in chondrocyte lineage tracing. We have developed two transgenic systems to label cartilage cells throughout the body with fluorescent proteins. One system strongly labels early tadpole cartilages only. The other system inducibly labels forming cartilages at any developmental stage. We examined cartilages of the skull (viscero- and neurocranium), and identified larval cartilages that either resorb or remodel into adult cartilages. Our data show that the adult otic capsules, tecti anterius and posterius, hyale, and portions of Meckel\u27s cartilage are derived from larval chondrocytes. Our data also suggest that most adult cartilages form de novo, though we cannot rule out the potential for extreme larval chondrocyte proliferation or de- and re-differentiation, which could dilute our fluorescent protein signal. The transgenic lineage tracing strategies developed here are the first examples of inducible, skeleton-specific, lineage tracing in Xenopus

Attorney Fees as Superfund Response Costs

Although other areas of natural resources law have been hit by hard times, the environ- mental area is burgeoning. The intricacies of the Comprehensive Environmental Response, Com- pensation and Liability Act (CERCLA or Super- fund), as amended by the Superfund Amendments and Reauthorization Act of 1986 (SARA), ensure attorney participation. Further- more, much of the fuel that drives CERCIA lit- igation is the presumption by many clients that their attorney fees are costs that can be re- covered as response costs under section 107 of CERCLA. 42 U.S.C. S 9607 (1983). Such an assumption may be a serious and costly mistake. It is well established that the federal gov- ernment can recover its attorney fees as re- sponse costs. This conclusion is based upon section 104(b)(1) of CERCLA which provides that the President may undertake such plan- ning, legal, fiscal, economic, engineering, ar- chitectural, and other studies or investigations as he may deem necessary or appropriate to plant and direct response actions, to recover the costs thereof and to enforce the provisions of this chapter. 42 U.S.C. � 9604(b)(1) (1988) (em- phasis added)

Local Thermal Equilibrium in Quantum Field Theory on Flat and Curved Spacetimes

The existence of local thermal equilibrium (LTE) states for quantum field theory in the sense of Buchholz, Ojima and Roos is discussed in a model-independent setting. It is shown that for spaces of finitely many independent thermal observables there always exist states which are in LTE in any compact region of Minkowski spacetime. Furthermore, LTE states in curved spacetime are discussed and it is observed that the original definition of LTE on curved backgrounds given by Buchholz and Schlemmer needs to be modified. Under an assumption related to certain unboundedness properties of the pointlike thermal observables, existence of states which are in LTE at a given point in curved spacetime is established. The assumption is discussed for the sets of thermal observables for the free scalar field considered by Schlemmer and Verch.Comment: 16 pages, some minor changes and clarifications; section 4 has been shortened as some unnecessary constructions have been remove

High Rate Discharge Studies of LI/SO2 Batteries

A battery composed of twelve lithium/sulfur dioxide D size cells in series is forced discharged at 21 amperes. This current is established by the proposed use of the battery and represented a discharge condition which might produce venting. Discharge of the battery into voltage reversal results not only in cells venting but also in the violent rupture of at least one cell

Thermodynamics of a d-wave Superconductor Near a Surface

We study the properties of an anisotropically paired superconductor in the presence of a specularly reflecting surface. The bulk stable phase of the superconducting order parameter is taken to have $d_{x^2-y^2}$ symmetry. Contributions by order parameter components of different symmetries vanish in the bulk, but may enter in the vicinity of a wall. We calculate the self-consistent order parameter and surface free energy within the quasiclassical formulation of superconductivity. We discuss, in particular, the dependence of these quantities on the degree of order parameter mixing and the surface to lattice orientation. Knowledge of the thermodynamically stable order parameter near a surface is a necessary precondition for calculating measurable surface properties which we present in a companion paper.Comment: 12 pages of revtex text with 12 compressed and encoded figures. To appear in J. Low Temp. Phys., December, 199

The linear tearing instability in three dimensional, toroidal gyrokinetic simulations

Linear gyro-kinetic simulations of the classical tearing mode in three-dimensional toroidal geometry were performed using the global gyro kinetic turbulence code, GKW . The results were benchmarked against a cylindrical ideal MHD and analytical theory calculations. The stability, growth rate and frequency of the mode were investigated by varying the current profile, collisionality and the pressure gradients. Both collision-less and semi-collisional tearing modes were found with a smooth transition between the two. A residual, finite, rotation frequency of the mode even in the absense of a pressure gradient is observed which is attributed to toroidal finite Larmor-radius effects. When a pressure gradient is present at low collisionality, the mode rotates at the expected electron diamagnetic frequency. However the island rotation reverses direction at high collisionality. The growth rate is found to follow a $\eta^{1/7}$ scaling with collisional resistivity in the semi-collisional regime, closely following the semi-collisional scaling found by Fitzpatrick. The stability of the mode closely follows the stability using resistive MHD theory, however a modification due to toroidal coupling and pressure effects is seen

Feedback methods for inverse simulation of dynamic models for engineering systems applications

Inverse simulation is a form of inverse modelling in which computer simulation methods are used to find the time histories of input variables that, for a given model, match a set of required output responses. Conventional inverse simulation methods for dynamic models are computationally intensive and can present difficulties for high-speed applications. This paper includes a review of established methods of inverse simulation,giving some emphasis to iterative techniques that were first developed for aeronautical applications. It goes on to discuss the application of a different approach which is based on feedback principles. This feedback method is suitable for a wide range of linear and nonlinear dynamic models and involves two distinct stages. The first stage involves design of a feedback loop around the given simulation model and, in the second stage, that closed-loop system is used for inversion of the model. Issues of robustness within closed-loop systems used in inverse simulation are not significant as there are no plant uncertainties or external disturbances. Thus the process is simpler than that required for the development of a control system of equivalent complexity. Engineering applications of this feedback approach to inverse simulation are described through case studies that put particular emphasis on nonlinear and multi-input multi-output models

Towards a construction of inclusive collision cross-sections in the massless Nelson model

The conventional approach to the infrared problem in perturbative quantum electrodynamics relies on the concept of inclusive collision cross-sections. A non-perturbative variant of this notion was introduced in algebraic quantum field theory. Relying on these insights, we take first steps towards a non-perturbative construction of inclusive collision cross-sections in the massless Nelson model. We show that our proposal is consistent with the standard scattering theory in the absence of the infrared problem and discuss its status in the infrared-singular case.Comment: 23 pages, LaTeX. As appeared in Ann. Henri Poincar\'