Joint Astrophysics Nascent Universe Satellite:. utilizing GRBs as high redshift probes

The Joint Astrophysics Nascent Universe Satellite (JANUS) is a multiwavelength cosmology mission designed to address fundamental questions about the cosmic dawn. It has three primary science objectives: (1) measure the massive star formation rate over 5 ≤ z ≤ 12 by discovering and observing high-z gamma-ray bursts (GRBs) and their afterglows, (2) enable detailed studies of the history of reionization and metal enrichment in the early Universe, and (3) map the growth of the first supermassive black holes by discovering and observing the brightest quasars at z ≥ 6. A rapidly slewing spacecraft and three science instruments – the X-ray Coded Aperture Telescope (XCAT), the Near InfraRed Telescope (NIRT), and the GAmma-ray Transient Experiment for Students (GATES) – make-up the JANUS observatory and are responsible for realizing the three primary science objectives. The XCAT (0.5–20 keV) is a wide field of view instrument responsible for detecting and localizing ∼60 z ≥ 5 GRBs, including ∼8 z ≥ 8 GRBs, during a 2-year mission. The NIRT (0.7–1.7 µm) refines the GRB positions and provides rapid (≤ 30 min) redshift information to the astronomical community. Concurrently, the NIRT performs a 20, 000 deg2 survey of the extragalactic sky discovering and localizing ∼300 z ≥ 6 quasars, including ∼50 at z ≥ 7, over a two-year period. The GATES provides high-energy (15 keV −1.0 MeV) spectroscopy as well as 60–500 keV polarimetry of bright GRBs. Here we outline the JANUS instrumentation and the mission science motivations

Bare electrodynamic tether ground simulations in a dense, high-speed plasma flow

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/76307/1/AIAA-2000-3869-300.pd

Properties of Modified Riemannian Extensions

Let M be an n-dimensional differentiable manifold with a symmetric connection ∇ and T*M be its cotangent bundle. In this paper, we study some properties of the modified Riemannian extension ğ∇, c on T*M defined by means of a symmetric (0, 2)-tensor field c on M. We get the conditions under which T*M endowed with the horizontal lift HJ of an almost complex structure J and with the metric ğ∇, c is a Kähler-Norden manifold. Also curvature properties of the Levi-Civita connection of the metric ğ∇, c are presented.Пусть M - n-мерное дифференцируемое многообразие с симметричной связностью ∇ а T*M - его кокасательное расслоение. В статье изучены некоторые свойства модифицированного риманова расширения ğ ∇, c на T*M, которое определяется с помощью симметричного (0, 2)-тензорного поля c на M. Получены условия, при которых T*M, наделенное горизонтальным лифтом HJ почти комплексной структуры J и метрикой ğ∇, c, является многообразием Kэлера-Нордена. Также представлены свойства кривизны связности Леви- Чивита метрики ğ ∇ , c.Нехай M — n-мірний диференційовний многовид із симетричного зв'язністго ∇, а T*M — його кодотичне розшарування. В статті вивчено деякі властивості модифікованого ріманова розширення ğ ∇, c на T*M, яке визначається за допомогою симетричного (0, 2)-тензорного поля с на М. Отримано умови, за яких T*M, наділене горизонтальним ліфтом HJ майже комплексної структури J і метрикого ğ∇, c, є многовидом Келера-Нордена. Також представлені властивості кривини зв'язності Леві-Чівіти метрики ğ∇, c

Leukocyte-specific protein 1 interacts with DC-SIGN and mediates transport of HIV to the proteasome in dendritic cells

Dendritic cells (DCs) capture and internalize human immunodeficiency virus (HIV)-1 through C-type lectins, including DC-SIGN. These cells mediate efficient infection of T cells by concentrating the delivery of virus through the infectious synapse, a process dependent on the cytoplasmic domain of DC-SIGN. Here, we identify a cellular protein that binds specifically to the cytoplasmic region of DC-SIGN and directs internalized virus to the proteasome. This cellular protein, leukocyte-specific protein 1 (LSP1), was defined biochemically by immunoprecipitation and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. LSP1 is an F-actin binding protein involved in leukocyte motility and found on the cytoplasmic surface of the plasma membrane. LSP1 interacted specifically with DC-SIGN and other C-type lectins, but not the inactive mutant DC-SIGNΔ35, which lacks a cytoplasmic domain and shows altered virus transport in DCs. LSP1 diverts HIV-1 to the proteasome. Down-regulation of LSP1 with specific small interfering RNAs in human DCs enhanced HIV-1 transfer to T cells, and bone marrow DCs from lsp1−/− mice also showed an increase in transfer of HIV-1BaL to a human T cell line. Proteasome inhibitors increased retention of viral proteins in lsp1+/+ DCs, and substantial colocalization of virus to the proteasome was observed in wild-type compared with LSP1-deficient cells. Collectively, these data suggest that LSP1 protein facilitates virus transport into the proteasome after its interaction with DC-SIGN through its interaction with cytoskeletal proteins

Spatio-Temporal Fusion Networks for Action Recognition

The video based CNN works have focused on effective ways to fuse appearance and motion networks, but they typically lack utilizing temporal information over video frames. In this work, we present a novel spatio-temporal fusion network (STFN) that integrates temporal dynamics of appearance and motion information from entire videos. The captured temporal dynamic information is then aggregated for a better video level representation and learned via end-to-end training. The spatio-temporal fusion network consists of two set of Residual Inception blocks that extract temporal dynamics and a fusion connection for appearance and motion features. The benefits of STFN are: (a) it captures local and global temporal dynamics of complementary data to learn video-wide information; and (b) it is applicable to any network for video classification to boost performance. We explore a variety of design choices for STFN and verify how the network performance is varied with the ablation studies. We perform experiments on two challenging human activity datasets, UCF101 and HMDB51, and achieve the state-of-the-art results with the best network

The VOrtex Ring Transit EXperiment (VORTEX) GAS project

Get Away Special (GAS) payload G-093, also called VORTEX (VOrtex Ring Transit EXperiment), is an investigation of the propagation of a vortex ring through a liquid-gas interface in microgravity. This process results in the formation of one or more liquid droplets similar to earth based liquid atomization systems. In the absence of gravity, surface tension effects dominate the drop formation process. The Shuttle's microgravity environment allows the study of the same fluid atomization processes as using a larger drop size than is possible on Earth. This enables detailed experimental studies of the complex flow processes encountered in liquid atomization systems. With VORTEX, deformations in both the vortex ring and the fluid surface will be measured closely for the first time in a parameters range that accurately resembles liquid atomization. The experimental apparatus will record images of the interactions for analysis after the payload has been returned to earth. The current design of the VORTEX payload consists of a fluid test cell with a vortex ring generator, digital imaging system, laser illumination system, computer based controller, batteries for payload power, and an array of housekeeping and payload monitoring sensors. It is a self-contained experiment and will be flown on board the Space Shuttle in a 5 cubic feet GAS canister. The VORTEX Project is entirely run by students at the University of Michigan but is overseen by a faculty advisor acting as the payload customer and the contact person with NASA. This paper summarizes both the technical and programmatic aspects of the VORTEX Project

Archaeosomes made of Halorubrum tebenquichense total polar lipids: A new source of adjuvancy

Background: Archaeosomes (ARC), vesicles prepared from total polar lipids (TPL) extracted from selected genera and species from the Archaea domain, elicit both antibody and cell-mediated immunity to the entrapped antigen, as well as efficient cross priming of exogenous antigens, evoking a profound memory response. Screening for unexplored Archaea genus as new sources of adjuvancy, here we report the presence of two new Halorubrum tebenquichense strains isolated from grey crystals (GC) and black mood (BM) strata from a littoral Argentinean Patagonia salt flat. Cytotoxicity, intracellular transit and immune response induced by two subcutaneous (sc) administrations (days 0 and 21) with BSA entrapped in ARC made of TPL either form BM (ARC-BM) and from GC (ARC-GC) at 2% w/w (BSA/lipids), to C3H/HeN mice (25 μg BSA, 1.3 mg of archaeal lipids per mouse) and boosted on day 180 with 25 μg of bare BSA, were determined. Results: DNA G+C content (59.5 and 61.7% mol BM and GC, respectively), 16S rDNA sequentiation, DNA-DNA hybridization, arbitrarily primed fingerprint assay and biochemical data confirmed that BM and GC isolates were two non-previously described strains of H. tebenquichense. Both multilamellar ARC mean size were 564 ± 22 nm, with -50 mV zeta-potential, and were not cytotoxic on Vero cells up to 1 mg/ml and up to 0.1 mg/ml of lipids on J-774 macrophages (XTT method). ARC inner aqueous content remained inside the phago-lysosomal system of J-774 cells beyond the first incubation hour at 37°C, as revealed by pyranine loaded in ARC. Upon subcutaneous immunization of C3H/HeN mice, BSA entrapped in ARC-BM or ARC-GC elicited a strong and sustained primary antibody response, as well as improved specific humoral immunity after boosting with the bare antigen. Both IgG1 and IgG2a enhanced antibody titers could be demonstrated in long-term (200 days) recall suggesting induction of a mixed Th1/Th2 response. Conclusion: We herein report the finding of new H. tebenquichense non alkaliphilic strains in Argentinean Patagonia together with the adjuvant properties of ARC after sc administration in mice. Our results indicate that archaeosomes prepared with TPL from these two strains could be successfully used as vaccine delivery vehicles

Use of polyethylene glycol coatings for optical fibre humidity sensing

Humidity induced change in the refractive index and thickness of the polyethylene glycol (PEG) coatings are in situ investigated for a range from 10 to 95%, using an optical waveguide spectroscopic technique. It is experimentally demonstrated that, upon humidity change, the optical and swelling characteristics of the PEG coatings can be employed to build a plastic fibre optic humidity sensor. The sensing mechanism is based on the humidity induced change in the refractive index of the PEG film, which is directly coated onto a polished segment of a plastic optical fibre with dip-coating method. It is observed that PEG, which is a highly hydrophilic material, shows no monotonic linear response to humidity but gives different characteristics for various ranges of humidity levels both in index of refraction and in thickness. It undergoes a physical phase change from a semi-crystal line structure to a gel one at around 80% relative humidity. At this phase change point, a drastic decrease occurs in the index of refraction as well as a drastic increase in the swelling of the PEG film. In addition, PEG coatings are hydrogenated in a vacuum chamber. It is observed that the hydrogen has a preventing effect on the humidity induced phase change in PEG coatings. Finally, the possibility of using PEG coatings in construction of a real plastic fibre optic humidity sensor is discussed. (C) 2008 The Optical Society of Japan

Archaeosomes made of Halorubrum tebenquichense total polar lipids: a new source of adjuvancy

<p>Abstract</p> <p>Background</p> <p>Archaeosomes (ARC), vesicles prepared from total polar lipids (TPL) extracted from selected genera and species from the Archaea domain, elicit both antibody and cell-mediated immunity to the entrapped antigen, as well as efficient cross priming of exogenous antigens, evoking a profound memory response. Screening for unexplored Archaea genus as new sources of adjuvancy, here we report the presence of two new <it>Halorubrum tebenquichense </it>strains isolated from grey crystals (<it>GC</it>) and black mood (<it>BM</it>) strata from a littoral Argentinean Patagonia salt flat. Cytotoxicity, intracellular transit and immune response induced by two subcutaneous (sc) administrations (days 0 and 21) with BSA entrapped in ARC made of TPL either form <it>BM </it>(ARC-BM) and from <it>GC </it>(ARC-GC) at 2% w/w (BSA/lipids), to C3H/HeN mice (25 μg BSA, 1.3 mg of archaeal lipids per mouse) and boosted on day 180 with 25 μg of bare BSA, were determined.</p> <p>Results</p> <p>DNA G+C content (59.5 and 61.7% mol <it>BM </it>and <it>GC</it>, respectively), 16S rDNA sequentiation, DNA-DNA hybridization, arbitrarily primed fingerprint assay and biochemical data confirmed that <it>BM </it>and <it>GC </it>isolates were two non-previously described strains of <it>H. tebenquichense</it>. Both multilamellar ARC mean size were 564 ± 22 nm, with -50 mV zeta-potential, and were not cytotoxic on Vero cells up to 1 mg/ml and up to 0.1 mg/ml of lipids on J-774 macrophages (XTT method). ARC inner aqueous content remained inside the phago-lysosomal system of J-774 cells beyond the first incubation hour at 37°C, as revealed by pyranine loaded in ARC. Upon subcutaneous immunization of C3H/HeN mice, BSA entrapped in ARC-BM or ARC-GC elicited a strong and sustained primary antibody response, as well as improved specific humoral immunity after boosting with the bare antigen. Both IgG1 and IgG2a enhanced antibody titers could be demonstrated in long-term (200 days) recall suggesting induction of a mixed Th1/Th2 response.</p> <p>Conclusion</p> <p>We herein report the finding of new <it>H. tebenquichense </it>non alkaliphilic strains in Argentinean Patagonia together with the adjuvant properties of ARC after sc administration in mice. Our results indicate that archaeosomes prepared with TPL from these two strains could be successfully used as vaccine delivery vehicles.</p

Proceedings of the second "international Traveling Workshop on Interactions between Sparse models and Technology" (iTWIST'14)

The implicit objective of the biennial "international - Traveling Workshop on Interactions between Sparse models and Technology" (iTWIST) is to foster collaboration between international scientific teams by disseminating ideas through both specific oral/poster presentations and free discussions. For its second edition, the iTWIST workshop took place in the medieval and picturesque town of Namur in Belgium, from Wednesday August 27th till Friday August 29th, 2014. The workshop was conveniently located in "The Arsenal" building within walking distance of both hotels and town center. iTWIST'14 has gathered about 70 international participants and has featured 9 invited talks, 10 oral presentations, and 14 posters on the following themes, all related to the theory, application and generalization of the "sparsity paradigm": Sparsity-driven data sensing and processing; Union of low dimensional subspaces; Beyond linear and convex inverse problem; Matrix/manifold/graph sensing/processing; Blind inverse problems and dictionary learning; Sparsity and computational neuroscience; Information theory, geometry and randomness; Complexity/accuracy tradeoffs in numerical methods; Sparsity? What's next?; Sparse machine learning and inference.Comment: 69 pages, 24 extended abstracts, iTWIST'14 website: http://sites.google.com/site/itwist1