Antidiabetic activity of Trichosanthes cucumerina in normal and streptozotocin–induced diabetic rats

Aerial parts of Trichosanthes cucumerina (Family: Cucurbitaceae) are used in traditional medical systems for treatment of diabetes and other diseases. The present study was designed to experimentally evaluate the antidiabetic potential of a hot water extract (HWE) of T. cucumerina (TC) aerial parts. In normoglycemic rats, HWE mediated (a) a dose dependent reduction in fasting blood glucose (FBS) levels (by 35% at 4h post-treatment with dose of 750 mg/kg) and (b) a significant (

An analysis of student engagement when taught in classes of different sizes in rural, regional and metropolitan campuses of an Australian university

This study investigates the impact of class size on student engagement and student performance. It is based on an analysis of student university enter scores, student grades and student evaluations in metropolitan, regional and rural campuses of an Australian universityduring trimester 1 of years 2008, 9 &amp; 10. Past literature appears to support the predominant influence of the class size effect on learning, though some findings are mixed and inconclusive. Contrary to the accepted view that higher entry level scores result in higher grades and, conversely, lower entry level scores result in lower grades, the findings suggest that factorsother than entry level scores, contribute to student outcomes and student engagement. The study reveals that student satisfaction of teaching quality is higher in the rural and regional campuses where the cohorts are smaller than at the metropolitan campus. This may be an indication that class size seems to have a predominant influence on student engagement and learning outcomes.<br /

Case report: Rare skeletal manifestations in a child with primary hyperparathyroidism

Background: Primary hyperparathyroidism (PHPT) is uncommon among children with an incidence of 1:300,000. This diagnosis is often missed in children in contrast to adults where it is detected at a pre symptomatic stage due to routine blood investigations. Etiology of PHPT can be due to adenoma, hyperplasia or rarely carcinoma. Case presentation: A 12year old Sri Lankan girl presented with progressive difficulty in walking since 1year. On examination she had bilateral genu valgum. Skeletal survey revealed valgus deformity of knee joints, bilateral subluxation of upper femoral epiphysis(SUFE), epiphyseal displacement of bilateral humeri, rugger jersey spine and subperiosteal bone resorptions in lateral aspects of 2nd and 3rd middle phalanges. There were no radiological manifestations of rickets. Metabolic profile revealed hypercalcemia with hypophosphatemia. Intact parathyroid hormone levels were elevated at 790pg/ml. Vitamin D levels were deficient. She had low bone mineral density with Z score of -3.4. Vitamin D supplementation resulted in worsening of hypercalcemia without reduction in PTH levels. Tc 99 Sestamibi uptake scan showed abnormal tracer retention in left inferior pole of thyroid. A large parathyroid gland was removed with histology favoring parathyroid adenoma. Post operatively she developed hypocalcemia. Bilateral osteotomy was done for SUFE and further surgeries for correction of limb deformities planned. Conclusion: PHPT in children is usually diagnosed late when irreversible organ damage has occurred. Children can present with non specific symptoms involving gastrointestinal, musculoskeletal, renal and neurological systems. PHPT can cause disarray in bone and epiphysis in children during pubertal growth spurt. Genu valgum and SUFE are rare skeletal manifestations in PHPT and only 10 cases of genu valgum and 9 cases of SUFE have been reported up to now. So far no cases have been reported on epiphyseal displacement of humeri. Awareness regarding the occurrence of these rare skeletal manifestations especially during puberty is important for early diagnosis to prevent irreversible outcomes

Factors influencing postgraduate students' university choice in Nigeria.

An understanding of postgraduate students’ choice criteria for universities selection is essential for marketing higher education, securing the long-term success of the universities, as well as its marketing strategy. While previous studies have focused on developed countries and undergraduate students, this chapter explores factors influencing postgraduate students’ decision making. The study recognises that the rapid expansion of the enrolment of undergraduates has also stimulated students’ enthusiasm for postgraduate studies and importantly, postgraduate students have prior experience in a university service environment (compared to undergraduate students). The semi-structured interview was conducted with first-year postgraduate students at a private university in South-West, Nigeria. Some of the participants were new to the university while some did their undergraduate studies there. Findings from the study revealed four key factors which are the desire to study for a postgraduate degree, the facilities of the University, including its geographical location, the courses on offer and influence of other stakeholders like parents, siblings and friends. This influence of stakeholders aligns with the fundamental values in a collectivist culture like Nigeria. This study contributes to literature on higher education marketing, especially in Africa and for postgraduate students. The chapter presents an integral insight into marketing higher education in Nigeria and Africa, as this is an under-researched area

Piper betle L. Piperaceae

Artanthe hexagyna Miq.; Betela mastica Raf.; Chavica betle (L.) Miq.; Chavica blumei Miq.; Chavica chuvya Miq.; Chavica densa Miq.; Chavica siriboa (L.) Miq.; Cubeba melamiri Miq.; Cubeba seriboa Miq.; Macropiper potamogetonifolium (Opiz) Miq.; Piper anisodorum Blanco; Piper bathicarpum C.DC.; Piper bidentatum Stokes; Piper blancoi Merr.; Piper blumei (Miq.) Backer; Piper canaliculatum Opiz; Piper carnistilum C.DC.; Piper densum Blume; Piper fenixii C.DC.; Piper macgregorii C.DC.; Piper malamiri Blume; Piper malamiris L.; Piper malarayatense C.DC.; Piper marianum Opiz; Piper philippinense C.DC.; Piper pinguispicum C.DC. & Koord.; Piper potamogetonifolium Opiz; Piper puberulinodum C.DC.; Piper rubroglandulosum Chaveer. & Mokkamul; Piper saururus Burm.; Piper siriboa L.; Piperi betlum (L.) St.-Lag

Gastroprotective effect of Piper betle Linn. leaves grown in Sri Lanka

Background: Piper betle Linn. (Piperaceae) is used as a remedy for gastric ulcers in traditional medicinal systems in Sri Lanka. However, the gastroprotective activity has never been proven scientifically using betel leaves grown in Sri Lanka. Objective: To evaluate the gastroprotective activity of hot aqueous extract (HAE) and cold ethanolic extract (CEE) of P. betle in rats as the experimental model. Materials and Methods: Three doses (200, 300, and 500 mg/kg/bw) of both extracts were evaluated for the gastroprotective activity against ethanol induced gastric ulcers in rats. The parameters evaluated were (a) effects of HAE on mucus content adhering to the wall of the gastric mucosa, (b) acidity (total and free), (c) volume and (d) pH of the gastric juice. Results: Oral administration of HAE and CEE provided marked dose dependent (HAE: r2 = 0.97; CEE: r2 = 0.96) and significant (P ≤ 0.05) protection against gastric damage caused by absolute ethanol. The gastroprotective effect of CEE was comparable with that of HAE. Further, gastroprotective activity of the highest dose of both extracts were significantly greater (P ≤ 0.05) than that of misoprostol, the reference drug. The HAE significantly (P ≤ 0.05) increased the mucus content adhering to the wall of the gastric mucosa and inhibited the volume of gastric acid. However, acidity (total and free) and pH of the gastric juice remained unaltered. Conclusion: It is concluded that both HAE and CEE of P. betle leaves have a strong gastroprotective activity