Necrotizing Enterocolitis with Perforation and Peritoneal Drainage in the Very Low Birth Weight Infant: A Case with Favourable Outcome

A enterocolite necrosante (ECN) constitui o problema gastrointestinal mais grave e mais frequente no recém-nascido (RN) de baixo peso. A melhoria na taxa de sobrevivência tem sido atribuída ao diagnóstico mais precoce e à experiência adquirida no tratamento do recém-nascido pré-termo em estado crítico. Desde 1977 que a drenagem peritoneal como actuação prioritária nos quadros de ECN tem sido preconizada nos recém- -nascidos de peso inferior a 1500 g com perfuração intestinal, e nos de peso superior a 1500 g com instabilidade hemodinâmica. Neste artigo relata-se o caso de um recém-nascido, com 1473 g de peso e 30 semanas de idade gestacional, ECN, sinais de perfuração intestinal e de instabilidade hemodinâmica, o qual foi submetido a drenagem peritoneal com evolução favorável e sem sequelas. Na discussão faz-se referência especial, de acordo com dados de literatura, aos mecanismos que explicam os bons resultados do procedimento em cerca de 2/3 dos casos de ECN com perfuração, os quais estão relacionados com as características particulares da cicatrização nos tecidos imaturos. Em conclusão, admite-se que a drenagem peritoneal deverá constituir a forma de actuação prioritária nos casos de ECN com perfuração e instabilidade hemodinâmica em RN pré-termo de muito baixo peso

Comportamento de duas variedades de algodoeiro depois da inoculação com Cotton leaf roll mosaic virus.

Com o objetivo de estudar a distribuição do vírus em plantas de algodão, foi desenvolvido um experimento na Embrapa Arroz e Feijão, em Santo Antônio de Goiás, utilizando-se as cultivares de algodão BRS 293 (resistente) e FM 966 (suscetível).Pôster - graduação

Uncommon Movement Disorders in Chronic Hepatic Disease with Response to Rifaximin

Background: Chronic hepatic disease can present with extrapyramidal symptoms. We describe two cases that presented with highly unusual movement disorders: ballism and gait freezing. Case report: Patient 1 is a 42-year-old man with previous episodes of hepatic encephalopathy (HE) who presented with upper limb dystonia and generalized chorea that progressed to ballism. Patient 2 is a 55-year-old woman who presented with pronounced gait freezing. In both patients, features of HE and acquired hepatocerebral degeneration coexisted. They improved markedly, though transiently, with rifaximin. Discussion: Ammonia-reducing treatments should be considered in patients presenting with movement disorders due to chronic liver disease

Early-life stress affects drug abuse susceptibility in adolescent rat model independently of depression vulnerability

The development of substance abuse problems occurs due to a diverse combination of risk factors. Among these risks, studies have reported depression and early-life stress as of importance. These two factors often occur simultaneously, however, there is a lack of understanding of how their combined effect may impact vulnerability to drug abuse in adolescence. The present study used rats with different vulnerability to depression (Wistar and Wistar-Kyoto) to investigate the impact of maternal separation (MS) on emotional state and drug addiction vulnerability during the adolescence period. Mothers and their litters were subjected to MS (180 min/day) from postnatal day 2 to 14. The offspring emotional state was assessed by observing their exploratory behavior. Drug abuse vulnerability was assessed through conditioning to cocaine. MS impacted the emotional state in both strains. Wistar responded with increased exploration, while Wistar-Kyoto increased anxiety-like behaviours. Despite the different coping strategies displayed by the two strains when challenged with the behavioural tests, drug conditioning was equally impacted by MS in both strains. Early-life stress appears to affect drug abuse vulnerability in adolescence independently of a depression background, suggesting emotional state as the main driving risk factor.info:eu-repo/semantics/publishedVersio

Long-term effects of chronic cocaine exposure throughout adolescence on anxiety and stress responsivity in a wistar rat model

Adolescents display increased vulnerability to engage in drug experimentation. This is often considered a risk factor for later drug abuse. In this scenario, the permanent effects of cocaine exposure during adolescence on anxiety levels and stress responsivity, which may result in behavioral phenotypes prone to addiction, are now starting to be unveiled. Thus, the purpose of the present study was to evaluate the long-lasting effects of chronic cocaine administration during adolescence, on anxiety-like behavior and on stress response. Adolescent male Wistar rats were daily administered 45-mg cocaine/kg of body weight in three equal intraperitoneal doses with 1-h interval, from postnatal day (PND) 35 to 50. The effects of cocaine administration on anxiety levels, assessed in the Elevated Plus Maze (EPM), and on social stress response, assessed in the resident-intruder paradigm (R/I), were evaluated 10 days after withdrawal, when rats were reaching the adulthood. The underlying dopaminergic activity, and the corticosterone and testosterone levels were determined. Our results showed that cocaine induced long-lasting alterations in the hypothalamus-pituitary-adrenals (HPA) axis function and in testosterone levels. Such alterations resulted in significant and enduring changes in behavioral responses to environmental challenges, such as the EPM and R/I, including the evaluation of potential threats that may lead to high-risk behavior and low-benefit choices. This was further supported by an altered dopaminergic function in the amygdala and hippocampus. The present findings provide new insights into how the use of cocaine during adolescent development may modulate emotional behavior later in life. Compromised ability to recognize and deal with potential threats is an important risk factor to perpetuate compulsive drug seeking and relapse susceptibility.info:eu-repo/semantics/publishedVersio

Ausência do lentivírus ovino em rebanhos nativos do município de Sobral-Ce.

O trabalho teve como objetivo realizar uma enquete sorológica no município de Sobral, utilizando dois testes diagnósticos: o IDGA e o IB

Uso e aplicação de formulações dietéticas para cordeiros Morada Nova sob terminação em confinamento no semiárido brasileiro, tendo como referência o NRC (2007): morfometria e peso da carcaça fria.

Resumo: O objetivo deste trabalho foi avaliar o uso e a aplicação de formulações dietéticas, tomando por base o NRC (2007), sobre a morfometria e o peso de carcaça fria de cordeiros da raça Morada Nova sob terminação. O experimento foi realizado na cidade de Sobral-CE, no período de 16 de Dezembro de 2013 a 21 de Fevereiro de 2014. Foram utilizados vinte animais distribuídos em delineamento inteiramente ao acaso em esquema fatorial 2 x 2 (duas dietas prescritas pelo NRC (2007) para a categoria em estudo - maturidade precoce e tardia e restrição ou não de nutrientes). Os parâmetros avaliados foram: peso da carcaça fria, comprimento interno da carcaça, profundidade do tórax, perímetro do tórax, garupa e pernil, comprimento de perna e índice de compacidade da carcaça. Os dados foram submetidos à análise de variância e as médias comparadas pelo teste de Tukey a 5%. Houve efeito significativo entre dietas conforme o NRC (2007) para o peso de carcaça fria e medidas morfométricas, com exceção do comprimento interno da carcaça, profundidade do tórax e comprimento de pernil. O adensamento energético indicado na formulação para maturidade precoce de acordo com o NRC (2007) contribui para o maior desenvolvimento muscular da carcaça de cordeiros Morada Nova terminados em confinamento. [Use and application of dietary formulations for Morada Nova lambs under feedlot finishing in the brazilian semi-arid, based on the NRC (2007): Morphometry and cold carcass weight]. Abstract: The objective of this study was to evaluate the use and application of dietary formulations for Morada Nova lambs under feedlot finishing, based on the NRC (2007), about the morphometry and cold carcass weight. The experiment was conducted in Sobral-Ceará-Brazil, in the period 16 December 2013 to 21 February 2014. Twenty animals distributed in a completely randomized design in a factorial 2x2 (two diets prescribed by NRC (2007) for the category under study - early and late maturity and nutrient restriction or not). The parameters evaluated were: cold carcass weight, internal carcass length, chest depth, chest girth, rump and shank, leg length and carcass compactness index. Data were subjected to analysis of variance and means were compared by Tukey test at 5%. There was a significant effect between diets according to NRC (2007) for cold carcass weight and morphometric measurements except the internal carcass length, chest depth and leg length. The energy density formulation indicated for early maturity according to NRC (2007) contributes to the greater muscular development of housing Morada Nova lambs feedlot

Plasmacytoma of the lumbar spine

Solitary bone plasmacytoma is a plasma cell disorder characterized by the formation of a single tumor in the bone. Most commonly, the tumor develops in the spine, and is progressively less frequent in the pelvis, ribs, upper extremities, skull, femur and sternum. Symptoms are mainly local. In most cases, multiple myeloma ensues, conferring it a poor prognosis. The authors describe the case of a 53-year-old male patient who presented with persistent low back pain without apparent cause until a radiography of the lumbar spine was performed. It revealed a lytic lesion, which was proven to be a plasmacytoma after a computed tomography guided biopsy