SME credit application, a text classification approach

Project Work presented as the partial requirement for obtaining a Master's degree in Statistics and Information Management, specialization in Marketing Research e CRMDuring the SME credit application process a credit expert will give a specific recommendation to the credit commercial advisor. This recommendation can be classified as positive, negative or partial. This project aims to construct a text classifier model in order to give the recommendation text one of the categories mentioned before. To achieve this, two models are tested using state-of-the-art architecture called BERT proposed by Google in 2019. The first model will use single sentence BERT classification model as proposed by Google. The second model will use SBERT architecture, where BERT embedding model will be fine-tuned for the specific task, a max-pooling layer is added to extract a fixed size vector for all the document and work under fully connected network architecture. Results show that the second approach got better results regarding accuracy, precision and recall. Despite of the bunch of limitations of computational capacity, limited number of tagged examples and BERT maximum sequence length the model show a good first approach to solve the current problem

Identificación de nuevas proteínas que interaccionan con CtIP: Implicación de PRMT5 y CCAR2 en la resección del ADN

DNA double-strand breaks (DSBs) represent the most cytotoxic DNA lesion that can arise from either endogenous and exogenous genotoxic stresses. There are two major and alternative pathways to repair DSBs: non-homologous endjoining (NHEJ) and homologous recombination (HR). The choice between these repair mechanisms is highly regulated in order to ensure an accurate repair and maintenance of genomic stability. The best-known regulatory step is DNA end resection, which leads to repair by HR whereas inhibits NHEJ. DNA end resection is an evolutionary conserved process that consists in 5’-3’ degradation of each DNA end, giving rise to 3’ ssDNA tails. CtIP is a key factor involved in initiation of end resection in humans, acting as a hub that integrates several cellular and environmental cues through different post-translational modifications and protein-protein interactions. Thus, in order to identify additional factors that regulate CtIP resection role, we performed Tandem Affinity Purification assay using U2OS cells expressing a double-tagged (GFP and FLAG) CtIP fusion. We isolated 10 new CtIP constitutive binding proteins, most of them with an effect in DNA end resection, either by stimulating it or hampering it. Among all these CtIP interactors, we focused on PRMT5 and CCAR2 and show that they play opposite roles in regulating DNA end resection. PRMT5 promotes initiation and stimulates processivity of DNA end resection, and it is required for survival to DSB-inducing agents. Otherwise, CCAR2 acts as an antagonist of CtIP by impairing resection initiation and limiting the extent of DNA that is resected, becoming an important regulator of the length of resection tracts. Despite affecting DNA end resection in different ways, depletion of either PRMT5 or CCAR2 disturbs the balance between NHEJ and HR for the repair of DSBs, suggesting that both proteins are essentials for preserving genomic integrity

Existence of solutions for non-linear boundary value problems

This Thesis contains a detailed collection of the different results proved by the author in her predoctoral stage. The interest of the non-linear differential equations is well-known. This is due to their applications in different fields, such as physics, economy, medicine, biology or chemistry. It is very important to make a precise study of the existence of solutions for this kind of problems, as well as their uniqueness or multiplicity. We focus on the qualitative analysis of diverse boundary value problems, both linear and non-linear ones. Indeed, in most of the cases, our aim is to prove the existence of constant sign solutions in their definition interval. This interest comes from the constant sign of many of the magnitudes which are modelled by this kind of problems

The eigenvalue characterization for the constant sign Green’s functions of (k,n−k)(k,n−k) problems

This paper is devoted to the study of the sign of the Green’s function related to a general linear nth-order operator, depending on a real parameter, Tn[M]Tn[M], coupled with the (k,n−k)(k,n−k) boundary value conditions. If the operator Tn[M¯]Tn[M¯] is disconjugate for a given M̄, we describe the interval of values on the real parameter M for which the Green’s function has constant sign. One of the extremes of the interval is given by the first eigenvalue of the operator Tn[M¯]Tn[M¯] satisfying (k,n−k)(k,n−k) conditions. The other extreme is related to the minimum (maximum) of the first eigenvalues of (k−1,n−k+1)(k−1,n−k+1) and (k+1,n−k−1)(k+1,n−k−1) problems. Moreover, if n−kn−k is even (odd) the Green’s function cannot be nonpositive (nonnegative). To illustrate the applicability of the obtained results, we calculate the parameter intervals of constant sign Green’s functions for particular operators. Our method avoids the necessity of calculating the expression of the Green’s function. We finalize the paper by presenting a particular equation in which it is shown that the disconjugation hypothesis on operator Tn[M¯]Tn[M¯] for a given M̄ cannot be eliminatedAlberto Cabada was partially supported by Ministerio de Educación, Cultura y Deporte, Spain, and FEDER, project MTM2013-43014-P. Lorena Saavedra was partially supported by Ministerio de Educación, Cultura y Deporte, Spain, and FEDER, project MTM2013-43014-P, and Plan I2C scholarship, Consellería de Educación, Cultura e O.U., Xunta de Galicia, and FPU scholarship, Ministerio de Educación, Cultura y Deporte, Spain. The authors would also like to express their special thanks to the reviewer of the paper for his/her remarks, which considerably improved the content of this paperS

Recursos digitales ofrecidos por el sielae para el estudio del Siglo de Oro. Creación, gestión y evolución de BIDISO

Ministerio de Economía y Competitividad; FFI2012-3436Galicia. Consellería de Cultura, Educación e Ordenación Universitaria; GRC2013/053

Cost-effectiveness of pharmacogenetic screening in the management of major depressive disorder in the Spanish Healthcare System

Background: Major depressive disorder (MDD) represents a sizable economic burden in Spain. Pharmacogenetic (PGx) screening to guide the choice of antidepressant medication (ADM) in MDD patients yields higher response and remission rates, which could reduce both healthcare and indirect costs. Methods: We built a cost-effectiveness probabilistic Markov model with microsimulation using Tree Age Pro 2022, simulating a patient cohort from the SNHS starting ADM for MDD, and comparing PGx screening before starting ADM versus no screening (No PGx). We carried out a probabilistic sensitivity analysis using the Monte Carlo simulation with microsimulation, set for 1000 iterations and 1000 microsimulation trials, both from societal and healthcare provider perspectives, for a time horizon of 3 years. Results: From a societal perspective, the model estimated a mean cost of 3172.85€ and effectiveness of 2.64 quality-adjusted life years (QALYs) for the No PGx strategy, and a mean cost of 1687.02 € and effectiveness of 2.84 QALYs for the PGx strategy. The mean ICER was −7820.56 €/QALY. From a healthcare provider perspective (no indirect costs considered), the mean cost was 662.62 € for the No PGx strategy, and 446.60 € for the PGx strategy. The mean ICER was −1130.16 €/QALY. Limitations: The heterogeneity of input data from the literature, the need for assumptions of homogeneous distribution of variables and events across population and time, and the inherent limitations of cost-effectiveness analysis should be considered. The model omits combined therapies (ADMs with mood stabilizers, antipsychotics, cognitive behavioral therapy…). Conclusions: PGx screening in MDD prior to ADM start is a dominant strategy in the SNH

Characterization of constant sign Green's function for a two-point boundary-value problem by means of spectral theory

This article is devoted to the study of the parameter’s set where the Green’s function related to a general linear nth-order operator, depending on a real parameter, Tn[M], coupled with many different two point boundary value conditions, is of constant sign. This constant sign is equivalent to the strongly inverse positive (negative) character of the related operator on suitable spaces related to the boundary conditions. This characterization is based on spectral theory, in fact the extremes of the obtained interval are given by suitable eigenvalues of the differential operator with different boundary conditions. Also, we obtain a characterization of the strongly inverse positive (negative) character on some sets, where non homogeneous boundary conditions are considered. To show the applicability of the results, we give some examples. Note that this method avoids the explicit calculation of the related Green’s function.This research was Partially supported by AIE Spain and FEDER, grants MTM2013-43014-P, MTM2016-75140-P. The second author was supported by FPU scholarship, Ministerio de Educaci´on, Cultura y Deporte, SpS

Quark mixings as a test of a new symmetry of quark Yukawa couplings

Based on the hierarchy exhibited by quarks masses at low energies, we assume that Yukawa couplings of up and down quarks are related by $Y_u\propto Y_d^2$ at grand unification scales. This ansatz gives rise to a symmetrical CKM matrix at the grand unification (GU) scale. Using three specific models as illustrative examples for the evolution down to low energies, we obtain the entries and asymmetries of the CKM matrix which are in very good agreement with their measured values. This indicates that the small asymmetry of the CKM matrix at low energies may be the effect of the renormalization group evolution only.Comment: LaTeX file, 10 pages including 1 tabl

Kupfer-type immunological synapses in vivo : Raison D'être of SMAC

T cells engage with antigen-presenting cells to form immunological synapses. These intimate contacts are characterized by the complex arrangement of molecules at the intercellular interface, which has been described as the supramolecular activation cluster (SMAC). However, due to T cells functioning without SMAC formation and the difficulties of studying these complex arrangements in vivo, its biological importance has been questioned. In light of recent data, we focus this review on the putative functionality of SMACs in T-cell synaptic contacts in vivo and emphasize the therapeutic potential of SMAC manipulation in immune-driven diseases

La conexión epistémica entre formación humanista y educación profesional universitaria

The conception of humanistic formation has been an omnipresent subject at collegeprofessional education. Both, in institutional statements and in more specific formative purposes,the relevance of education oriented by humanistic foundations frequently seems to be brought up.That is, regardless the debate related to the implications of conceiving to human beings as superiorentities. In this essay, the humanistic formation is examined from a distinct perspective and scarcelythematized. However, as far as it is concerned, especially significant: the epistemic dimension.Accordingly, even though this topic is analyzed from a particular view, an hegemonic interpretationof Humanism does not pretend to be exposed, in contrast with its more classical sense of valueorientation. With this background, three domains are proposed in order to focus the theoreticalanalysis, which are labeled the practical epistemic, the disciplinary epistemic, and the epistemicallyhuman. Thus, it is argued that college professional formation based on contemporary Humanismshould educationally contribute to develop a comprehension of epistemic problems involved to theprofessional performance. This last statement comprehends, at least, a broad notion of rationality,with awareness of its limits and scope, as well as a strict commitment with the inherent complexityof personal and social problems, and ultimately, with its own meaning of professional condition.La concepción de una formación de carácter humanista ha sido un tema multipresente en la educaciónprofesional universitaria. Tanto en declaraciones institucionales, como en propósitos formativos másparticularizados, aparece con frecuencia la importancia de alcanzar una educación orientada por principios de inspiración humanista. Esto último, con independencia del debate actual referente a las implicancias de una concepción de hombre como entidad superior en el universo. Este artículo examina el asunto de la formación humanista desde una arista poco tematizada, pero a nuestro juicio especialmente relevante: la dimensión epistémica. En ese sentido, aunque se trata el tema a partir de una perspectiva teórica singular, no se pretende presionar en dirección de una lectura hegemónica del Humanismo, en oposición con un enfoque más clásico de orientación valórica. Con estos antecedentes, se plantean tres dominios para enfocar el análisis teórico, que se nombran como: el epistémico práctico, el epistémico disciplinar y el epistémicamente humano. Así, en este trabajo se arguye que una formación profesional con base en un Humanismo contemporáneo, debe contribuir educativamente a desarrollar una comprensión de los problemas epistémicos integrados a la actuación profesional. Esto supone, al menos, una noción amplia de racionalidad, consciente de sus límites y alcances, así como un compromiso con la complejidadinherente de los problemas individuales y sociales; y con el mismo significado de la condición profesional