The botanical decoration of Estibaliz “Devant le temps”: Fluctuations of iconographic meaning in the light of artistic historiography

La portada Speciosa de la iglesia de Nuestra Señora de Estíbaliz (Álava) cuenta con una decoración vegetal sumamente rica y variada. Sin embargo, los investigadores que se han ocupado de su estudio han aportado visiones radicalmente opuestas, dividiéndose entre quienes consideraban su decoración como mero ornato y quienes apreciaban complejos simbolismos comprensibles sólo a la luz de los textos sagrados. Este singular caso de estudio nos permitirá reflexionar sobre el propio acto de historiar y sobre el modo en el que se relacionan las imágenes con el tiempo y con las personas que protagonizan cada una de las etapas en las que éstas son reactivadas. En un caso particular en el que no es posible conocer las motivaciones o intenciones de los constructores de esta portada, comprobaremos el valor de apreciar esos otros instantes en los que las imágenes son reapropiadas para un nuevo uso, estudio o interpretación.The Speciosa portal of the church of Our Lady of Estíbaliz (Álava) has a rich and varied botanical decoration. The researchers who have studied it have, however, developed radically opposed interpretations, dividing those who consider the decoration merely as ornament and those who appreciate complex symbolisms connected with sacred texts. This case study will allow us to think about the very act of historicising and about how the images are linked with time and with the people involved in every stage in which the images are reactivated. In a case such as this, where it is not possible to know the motivations or intentions of the builders of the portal, we will appreciate the value of considering those other instants in which the images are reappropriated to give them a new use, study or interpretation

An approach towards the visual culture of the Barroque festival : portraits of visual presences

En el presente estudio abordaremos brevemente algunas cuestiones relativas a la cultura visual de la fiesta barroca; y más específicamente, aquellas vinculadas a los retratos reales que se exponían durante los actos festivos. Para ello, pondremos especial énfasis en desarrollar los conceptos de presencia, cuerpo y virtualidad –aplicados a dichas obras u objetos visuales–, desde un marco teórico novedoso como es el determinado por los estudios de la imagen o estudios de cultura visual (Bildwissenschaft, Bildanthropologie y visual studies)

CNS involvement in myotonic dystrophy type 1: does sex play a role?

IntroductionMyotonic dystrophy type 1 (DM1) is a hereditary neuromuscular disorder affecting the central nervous system (CNS). Although sex differences have been explored in other neuromuscular disorders, research on this topic in DM1 remains limited. The present study aims to analyze sex differences (both the patient’s and disease-transmitting parent’s sex) with a focus on CNS outcomes.MethodsRetrospective data from 146 non-congenital DM1 patients were analyzed, including clinical, molecular, neuropsychological, and neuroradiological data. Sex and inheritance pattern differences were analyzed using t-tests, and ANOVA analyses were conducted to address the interactions.ResultsOverall, no significant sex differences were observed except in certain cognitive domains. However, individuals with maternal inheritance showed larger CTG expansion size, lower estimated IQs, and poorer performance on visual memory, executive functions, and language domains than those with paternal inheritance. Notably, IQ performance was independently influenced by inheritance pattern and CTG expansion.DiscussionThis study is the first to delve into sex differences in DM1 with a focus on CNS outcomes. While the results revealed the absence of a sex-specific clinic-molecular profile, more substantial CNS differences were observed between patients with maternal and paternal inheritance patterns. The hypothetical existence of genomic imprinting and its potential mechanism are discussed. These findings hold potential implications for aiding clinical management by improving genetic counseling and predicting disease severity and prognosis

Adecuación recreativa de los márgenes del río Ucero en el Burgo de Osma y la Olmeda (Soria)

En dicha adecuación de ambos márgenes del río Ucero, entre las localidades del Burgo de Osma y la Olmeda, vamos a llevar a cabo la construcción de una senda de 3,6 Km con dos parking, uno al inicio de la senda (Puente de la Güera) y otro al final de la senda (La Olmeda) , también se dispondrá con dos áreas de descanso, una a mitad del recorrido y otra al final de la senda ( La Olmeda) donde dispondremos de una caseta, bancos, fuente, etc… Con todo esto lo que queremos conseguir es potenciar el turismo de ambas localidades, la pasión por el deporten en la naturaleza, el senderismo en dicha zona aprovechando la belleza de su flora y fauna, mejorar la comunicación peatonal entre ambas localidades, etc…Grado en Ingeniería Forestal: Industrias Forestale

Investigación estadística en el ámbito de la criminología

Este proyecto pretende aplicar diversas técnicas estadísticas en el entorno criminológico con el fin de extraer conclusiones que aporten claridad a aspectos actuales y/o polémicos. Se trata de un análisis, mayoritariamente a nivel nacional, en el que se aspira a configurar el perfil base de un delincuente, además de estudiar la evolución y distribución de la criminalidad sobre el territorio español. Asimismo, mediante factores socioeconómicos, trata de establecer posibles causas de estos comportamientos delictivos consiguiendo centrar la atención en la raíz del problema y así hallar medidas para su prevención.This project aims to apply different statistical techniques in the criminological field in order to draw conclusions that bring clarity to current and/or controversial aspects. It is based on an analysis, mainly at national level, in which the aim is to configure the basic profile of an offender, besides studying the evolution and distribution of crime over Spanish territory. Additionally, through socioeconomic factors, it attempts to establish the causes of these criminal behaviours by focusing attention on the root of the problem, thus finding measures to prevent it.Grado en Estadístic

Autismoaren Espektroko Nahasmendua: bi kasuaren analisia

49 p. : il.-- Bibliogr.: p. 40-42[EUS] Autismoaren Espektroko Nahasmendua oinarri genetikoa duen disfuntzio neurologiko kronikoa da, txikitatik agertzen da eta bizitza osoan irauten du. Disfuntzio honen sintomek harreman sozialetan, komunikazioan (hitzezkoa eta ez-hitzezkoa) eta arrazoiketan eta portaeretan eragina dute. Gaur egun, gero eta kasu gehiago daude Haur Hezkuntzan, horregatik lan honen helburua da bi kasu aztertzea eta konparatzea, nahasmendu honen inguruko baita haur hauekin lan egiteko moduen inguruko informazio gehiago berenganatzeko. Lan honetan parte-hartu duten ikasleak bi dira, Mario 5 urtekoa eta Yassil 7 urtekoa. Haurrek eskola ezberdinetan ikasten dute eta bakoitzak jaso duen esku-hartzea ezberdina izan da. Lan honen datu bilketa elkarrizketak, behaketa eta egunerokoaren bidez aurrera eraman da, eta eskuratutako informazioarekin bi kasuen arteko konparazioa egin da. Honen ostean ondorio batzuk atera dira, eta bukatzeko, eta lan honi amaiera emateko, hobekuntza proposamen batzuk jasotzen dira.[ES] El trastorno del Espectro del Autismo es una disfunción neurológica crónica con base genética, que se manifiesta desde la niñez y dura toda la vida. Los síntomas de esta disfunción influyen en las relaciones sociales, en la comunicación (verbal y no verbal), en el razonamiento y en los comportamientos. En la actualidad, cada vez hay más casos en Educación Infantil, por lo que el objetivo de este trabajo es analizar y comparar dos casos para obtener más información sobre este trastorno y sobre la forma de trabajar con niños/as con este diagnóstico. Son dos los alumnos que han participado en este trabajo, Mario de 5 años y Yassil de 7 años. Ambos están matriculados en diferentes escuelas y la intervención que ha recibido cada uno de ellos ha sido diferente. La recogida de datos de este trabajo se ha llevado a cabo a través de entrevistas, observaciones y un diario, y con la información obtenida se ha realizado una comparación entre ambos casos, tras la cual se han extraído una serie de conclusiones y, para finalizar, se recogen una serie de propuestas de mejora

Una genealogía de la huella del rostro Memoria, tiempo, semejanza e imagen (S. V a.C – XVI d.C)

Màster Oficial en Estudis Avançats en Història de l'Art. Facultat de Geografia i Història de la UB. Curs: 2012, Tutor: Josep Casals Nava

Procesos ETL y de anonimización de interacciones en Moodle para su posterior análisis

Este proyecto pretende desarrollar una aplicación web que permita extraer de forma sistematizada la máxima cantidad de datos posibles del sistema e-learning con mayor aceptación universitaria, Moodle. Esta aplicación tiene dos finalidades bien diferenciadas: la primera está asociada al ámbito de investigación, posibilitando la obtención de cantidades masivas de información anonimizada; mientras que la segunda se vincula a la ayuda de la práctica docente. Esta última, permitirá a profesores universitarios acceder a los datos de sus asignaturas y monitorizarlas, analizarlas e incluso mejorarlas gracias a la ayuda de un dashboard desplegado en una segunda aplicación web. Ambas aplicaciones son desarrolladas en lenguajes de programación distintos (Python y R) por lo que son integradas de forma conjunta.This project aims to develop a web application that allows extract automatically the maximum amount of data possible from the e-learning system with the greatest university acceptance, Moodle. This application has two different purposes: the first is associated with the field of research, making it possible to obtain massive amounts of anonymized information; while the second is linked to help the university teaching. The last one will allow university professors to access the data of their subjects and monitor, analyze and improve them thanks to the aid of a dashboard deployed in a second web application. Both applications are developed in different programming languages (Python and R) so they are integrated in such a way that they are executed jointly.Grado en Ingeniería Informátic

Genome-wide meta-analysis for Alzheimer’s disease cerebrospinal fluid biomarkers

Amyloid-beta 42 (Aβ42) and phosphorylated tau (pTau) levels in cerebrospinal fluid (CSF) reflect core features of the pathogenesis of Alzheimer’s disease (AD) more directly than clinical diagnosis. Initiated by the European Alzheimer & Dementia Biobank (EADB), the largest collaborative effort on genetics underlying CSF biomarkers was established, including 31 cohorts with a total of 13,116 individuals (discovery n = 8074; replication n = 5042 individuals). Besides the APOE locus, novel associations with two other well-established AD risk loci were observed; CR1 was shown a locus for Aβ42 and BIN1 for pTau. GMNC and C16orf95 were further identified as loci for pTau, of which the latter is novel. Clustering methods exploring the influence of all known AD risk loci on the CSF protein levels, revealed 4 biological categories suggesting multiple Aβ42 and pTau related biological pathways involved in the etiology of AD. In functional follow-up analyses, GMNC and C16orf95 both associated with lateral ventricular volume, implying an overlap in genetic etiology for tau levels and brain ventricular volume.This work was supported by a grant (European Alzheimer DNA BioBank, EADB) from the EU Joint Programme, Neurodegenerative Disease Research (JPND). Amsterdam dementia Cohort (ADC): Research of the Alzheimer center Amsterdam is part of the neurodegeneration research program of Amsterdam Neuroscience. The Alzheimer Center Amsterdam is supported by Stichting Alzheimer Nederland and Stichting VUmc fonds. The clinical database structure was developed with funding from Stichting Dioraphte. Genotyping of the Dutch case-control samples was performed in the context of EADB (European Alzheimer DNA biobank) funded by the JPco-fuND FP-829-029 (ZonMW project number 733051061). Part of the work described in this study was carried out in the context of the Parelsnoer Institute (PSI). PSI was part of and funded by the Dutch Federation of University Medical Centers and has received initial funding from the Dutch Government (from 2007-2011). Since 2020, this work was carried out in the context of Parelsnoer clinical biobanks at Health-RI (https://www.health-ri.nl/initiatives/parelsnoer).Part of the genotyping included in this work was funded by the JPND EADB grant (German Federal Ministry of Education and Research (BMBF) grant: 01ED1619A). Alfredo Ramirez is also supported by the German Research Foundation (DFG) grants Nr: RA 1971/6-1, RA1971/7-1, and RA 1971/8-1. We would like to thank patients and controls who participated in this project. The Genome Research @ Fundacio ACE project (GR@ACE) is supported by Grifols SA, Fundacion bancaria 'La Caixa', Fundacio ACE, and CIBERNED. A.R. and M.B. receive support from the European Union/EFPIA Innovative Medicines Initiative Joint undertaking ADAPTED and MOPEAD projects (grant numbers 115975 and 115985, respectively). M.B. and A.R. are also supported by national grants PI13/02434, PI16/01861, PI17/01474, PI19/01240 and PI19/01301. Accion Estrategica en Salud is integrated into the Spanish National R + D + I Plan and funded by ISCIII (Instituto de Salud Carlos III)-Subdireccion General de Evaluacion and the Fondo Europeo de Desarrollo Regional (FEDER-'Una manera de hacer Europa'). The position held by I.dR. is funded by grant. FI20/00215. PFIS Contratos Predoctorales de Formacion en Investigacion en Salud. We would like to thank UCL Genomics, London, UK, for performing the genotyping analyses of the samples within the Gothenburg H70 Birth Cohort Studies and Clinical AD Sweden. The recruitment and clinical characterization of research participants at Washington University were supported by NIH P30AG066444, and P01AG003991. This work was supported by access to equipment made possible by the Hope Center for Neurological Disorders, the Neurogenomics and Informatics Center (NGI: https://neurogenom ics.wustl.edu/)and the Departments of Neurology and Psychiatry at Washington University School of Medicine. Research at the Belgian EADB site is funded in part by the Alzheimer Research Foundation (SAO-FRA), The Research Foundation Flanders (FWO), and the University of Antwerp Research Fund. FK is supported by a BOF DOCPRO fellowship of the University of Antwerp Research Fund. The work of Valdecilla was supported by grants from the Instituto de Salud Carlos III (Fondo de Investigacion Sanitario, PI08/0139, PI12/02288, PI16/01652, and PI20/01011), the JPND (DEMTEST PI11/03028), the CIBERNED, and the Siemens Healthineers. We thank the Valdecilla Biobank (PT17/0015/0019), integrated into the Spanish Biobank Network, for their support and collaboration in sample collection and management. Our heartfelt thanks to the participants of the Valdecilla Cohort for their generosity. The work of ADGEN was supported by EU Joint Programme-Neurodegenerative Disease Research (301220) and the Academy of Finland (338182). The DELCODE study (Study-ID:BN012) was supported and conducted by the German Center for Neurodegenerative Diseases (DZNE). The data samples were provided by the DELCODE study group. Details and participating sites can be found at www.dzne.de/en/research/studies/clinical-studies/delco de. The German Dementia Competence Network (KND) is funded by the German Federal Ministry of Education and Research (BMBF) grants Number: 01G10102, 01GI0420, 01GI0422, 01GI0423, 01GI0429, 01GI0431, 01GI0433, 04GI0434, 01GI0711. WF, SvdL, HHolstege, CT and PhS are recipients of ABOARD, which is a public-private partnership receiving funding from ZonMW (#73305095007) and HealthHolland, Topsector Life Sciences & Health (PPP-allowance; #LSHM20106). More than 30 partners participate in ABOARD (www.aboard-project.nl).ABOARD also receives funding from de Hersenstichting, Edwin Bouw Fonds and Gieskes-Strijbisfonds. IEJ was partially supported by NWO Gravitation program BRAINSCAPES: A Roadmap from Neurogenetics to Neurobiology (NWO: 024.004.012). AZ was supported by the Swedish Alzheimer Foundation (AF-939988, AF-930582, AF-646061, AF-741361), and the Dementia Foundation (2020-04-13, 2021-0417). ISk was supported by the Swedish state under the agreement between the Swedish government and the county councils, the ALFagreement (ALF 716681), the Swedish Research Council (no 11267, 825-2012-5041, 2013-8717, 2015-02830, 2017-00639, 2019-01096), Swedish Research Council for Health, Working Life and Welfare (no 2001-2646, 2001-2835, 2001-2849, 2003-0234, 2004-0150, 20050762, 2006-0020, 2008-1229, 2008-1210, 2012-1138, 2004-0145, 2006-0596, 2008-1111, 2010-0870, 2013-1202, 2013-2300, 20132496), Swedish Brain Power, Hjarnfonden, Sweden (FO2016-0214, FO2018-0214, FO2019-0163), the Alzheimer's Association Zenith Award (ZEN-01-3151), the Alzheimer's Association Stephanie B. Overstreet Scholars (IIRG-00-2159), the Alzheimer's Association (IIRG-03-6168, IIRG-09-131338) and the Bank of Sweden Tercentenary Foundation. SK was supported by the Swedish state under the agreement between the Swedish government and the county councils, the ALF-agreement (ALFGBG-81392, ALF GBG-771071), the Swedish Alzheimer Foundation (AF-842471, AF-737641, AF-939825), and the Swedish Research Council (2019-02075). MW was supported by the Swedish Research Council 2016-01590. DP was supported by BRAINSCAPES: A Roadmap from Neurogenetics to Neurobiology (grant no. 024.004.012), and a European Research Council advanced grant (Grant No, ERC-2018-AdG GWAS2FUNC 834057. HZ is a Wallenberg Scholar supported by grants from the Swedish Research Council (2018-02532), the European Research Council (681712), Swedish State Support for Clinical Research (ALFGBG-720931), the Alzheimer Drug Discovery Foundation (ADDF), USA (2018092016862), the European Union's Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement No 860197 (MIRIADE), and the UK Dementia Research Institute at UCL. KB was supported by the Swedish Research Council (#2017-00915), the Alzheimer Drug Discovery Foundation (ADDF), USA (#RDAPB201809-2016615), the Swedish Alzheimer Foundation (#AF-742881), Hjarnfonden, Sweden (#FO2017-0243), the Swedish state under the agreement between the Swedish government and the County Councils, the ALF-agreement (#ALFGBG-715986), the European Union Joint Program for Neurodegenerative Disorders (JPND2019-466-236), the National Institute of Health (NIH), USA, (grant #1R01AG06839801), and the Alzheimer's Association 2021 Zenith Award (ZEN-21848495). CC receives support from the National Institutes of Health (R01AG044546, R01AG064877, RF1AG053303, R01AG058501, U01AG058922, RF1AG058501, R01AG064614), and the Chuck Zuckerberg Initiative (CZI)