Hegel; Spinoza. La lógica de lo real como transformación o perspectiva

El presente trabajo de tesis doctoral se construye sobre un doble rechazo. Por un lado, de las posiciones dogmáticas inspiradas en el pensamiento dialéctico hegeliano que niegan a la filosofía de Spinoza la capacidad de proporcionar una explicación coherente de la realidad. Por otro lado, del intento iniciado por el materialismo francés de presentar la relación «Hegel-Spinoza» bien a través de la conjunción copulativa «y», o sea como una potencial coordinación, bien a través de la conjunción disyuntiva «o», es decir, como una identidad. Aun cuando Spinoza y Hegel comparten visión sobre lo que debe constituir el verdadero método en filosofía, debería ser más bien un punto y coma la marca textual utilizada para plasmar su relación: una yuxtaposición que separa dos unidades sintácticamente independientes que, sin embargo, mantienen una estrecha afinidad semántica. Hegel; Spinoza. Es la expresión de una conexión afectiva entre dos formas distintas de comprender la realidad que no se compromete con la promesa de superar ninguna de ellas, sino que simplemente las deja ser, una al lado de la otra; en su identidad, pero también, y sobre todo, en su diferencia. Desde un enfoque sistemático, el objetivo de esta yuxtaposición es presentar dos métodos (o lógicas) alternativos de captar conceptualmente la realidad: uno, el de Hegel, según el cual la transición entre determinaciones lógicas es el resultado de la necesidad inherente a cada determinación de ponerse a sí misma en lo otro de sí, es decir, de transformarse para seguir siendo sí misma; otro, el de Spinoza, que resuelve el problema de la relación entre determinaciones contradictorias mediante el recurso a diferentes perspectivas ontológicas o puntos de vista lógicos. Desde la dimensión de una historia de la filosofía, por otra parte, el objetivo es eliminar tres prejuicios arraigados en la aproximación que el materialismo francés ofrece de esta relación: en primer lugar, la lectura que Hegel habría presentado de Spinoza como una filosofía de la identidad abstracta; en segundo lugar, la percepción de la filosofía de Hegel como rígida y abstractamente teleológica; y, finalmente, la interpretación del spinozismo como una dialéctica materialista sin subjetividad.This doctoral dissertation is built upon a double rejection. On the one hand, of dogmatic positions inspired by Hegelian dialectical thinking, which deny Spinoza's philosophy the ability to provide a comprehensive explanation of reality. On the other hand, of the attempt by French materialism to present the relationship “Hegel-Spinoza” either through the copulative conjunction and, that is to say, as a potential coordination, or through the disjunctive conjunction or, that is, as an equation. Even though Spinoza and Hegel agree on what a method in philosophy is, it should rather be a semicolon the mark used to capture their relationship: a juxtaposition that separates two syntactically independent units that, nevertheless, maintain a close semantic relationship. Hegel; Spinoza. This is the expression of an effective connection that does not commit itself to the promise of overcoming either way of understanding reality, but simply lets them be next to each other; in their identity, but also, and above all, in their difference. According to a systematic approach, the aim of this juxtaposition is to present two alternative methods (or logics) of conceptually grasping reality: one (Hegel’s) according to which the transition between logical determinations is the result of the inherent need of each determination to posit itself into the other of itself, that is, to transform itself in order to remain itself; another (Spinoza’s) which solves the problem of relating contradictory determinations by means of different ontological perspectives or logical points of view. With regard to the history of philosophy, on the other hand, the purpose is to remove three prejudices strongly embedded in the French materialist approach to this relationship: first, the reading Hegel would have presented of Spinoza as a philosophy of abstract identity; second, the perception of Hegel’s philosophy as rigidly teleological; and, third, the interpretation of Spinozism as a materialist dialectic without subjectivity

A multiproxy study distinguishes environmental change from diagenetic alteration in the recent sedimentary record of the inner Cadiz Bay (SW Spain)

In this study, we reconstruct the recent environmental evolution of the inner Cadiz Bay using sedimentary records reaching back as far as AD 1700. We report lithological descriptions of the sediments and extensive mineralogical and geochemical analyses. An extraction technique that identifies different Fe phases provides an assessment of diagenetic alteration, which allows an estimation of the original organic matter inputs to the inner Cadiz Bay. Downcore variations in Corg/N ratios, δ13Corg and δ15N are related to changes in organic matter sources and the trophic state of the water column. The downcore records of selected trace metals (e.g. Pb, Zn and Cu) are interpreted to reflect changes in heavy metal pollution in the bay, while records of other elements (e.g. Mn and P) are likely overprinted by diagenetic alteration. Major environmental shifts took place during the 20th century, when the population around Cadiz Bay increased exponentially. Increases in sediment accumulation rates, organic matter inputs and heavy metal contents, in parallel with increases in δ13Corg and δ15N over this period, are interpreted as direct effects of the increasing anthropogenic influence in the area. The results of this study suggest that multiproxy approaches and detailed consideration of diagenetic overprinting are required to reconstruct past environmental conditions from coastal sediments

Peer effects and social preferences in voluntary cooperation: a theoretical and experimental analysis

Social preferences and social influence effects ("peer effects") are well documented, but little is known about how peers shape social preferences. Settings where social preferences matter are often situations where peer effects are likely too. In a gift-exchange experiment with independent payoffs between two agents we find causal evidence for peer effects. Efforts are positively correlated but with a kink: agents follow a low-performing but not a high-performing peer. This contradicts major theories of social preferences which predict that efforts are unrelated, or negatively related. Some theories allow for positively-related efforts but cannot explain most observations. Conformism, norm following and social esteem are candidate explanations

Transcriptomic Coordination in the Human Metabolic Network Reveals Links between n-3 Fat Intake, Adipose Tissue Gene Expression and Metabolic Health

Understanding the molecular link between diet and health is a key goal in nutritional systems biology. As an alternative to pathway analysis, we have developed a joint multivariate and network-based approach to analysis of a dataset of habitual dietary records, adipose tissue transcriptomics and comprehensive plasma marker profiles from human volunteers with the Metabolic Syndrome. With this approach we identified prominent co-expressed sub-networks in the global metabolic network, which showed correlated expression with habitual n-3 PUFA intake and urinary levels of the oxidative stress marker 8-iso-PGF2α. These sub-networks illustrated inherent cross-talk between distinct metabolic pathways, such as between triglyceride metabolism and production of lipid signalling molecules. In a parallel promoter analysis, we identified several adipogenic transcription factors as potential transcriptional regulators associated with habitual n-3 PUFA intake. Our results illustrate advantages of network-based analysis, and generate novel hypotheses on the transcriptomic link between habitual n-3 PUFA intake, adipose tissue function and oxidative stress

The GenTree Platform: growth traits and tree-level environmental data in 12 European forest tree species

Background: Progress in the field of evolutionary forest ecology has been hampered by the huge challenge of phenotyping trees across their ranges in their natural environments, and the limitation in high-resolution environmental information. Findings: The GenTree Platform contains phenotypic and environmental data from 4,959 trees from 12 ecologically and economically important European forest tree species: Abies alba Mill. (silver fir), Betula pendula Roth. (silver birch), Fagus sylvatica L. (European beech), Picea abies (L.) H. Karst (Norway spruce), Pinus cembra L. (Swiss stone pine), Pinus halepensis Mill. (Aleppo pine), Pinus nigra Arnold (European black pine), Pinus pinaster Aiton (maritime pine), Pinus sylvestris L. (Scots pine), Populus nigra L. (European black poplar), Taxus baccata L. (English yew), and Quercus petraea (Matt.) Liebl. (sessile oak). Phenotypic (height, diameter at breast height, crown size, bark thickness, biomass, straightness, forking, branch angle, fructification), regeneration, environmental in situ measurements (soil depth, vegetation cover, competition indices), and environmental modeling data extracted by using bilinear interpolation accounting for surrounding conditions of each tree (precipitation, temperature, insolation, drought indices) were obtained from trees in 194 sites covering the species’ geographic ranges and reflecting local environmental gradients. Conclusion: The GenTree Platform is a new resource for investigating ecological and evolutionary processes in forest trees. The coherent phenotyping and environmental characterization across 12 species in their European ranges allow for a wide range of analyses from forest ecologists, conservationists, and macro-ecologists. Also, the data here presented can be linked to the GenTree Dendroecological collection, the GenTree Leaf Trait collection, and the GenTree Genomic collection presented elsewhere, which together build the largest evolutionary forest ecology data collection available

Between but not within species variation in the distribution of fitness effects

New mutations provide the raw material for evolution and adaptation. The distribution of fitness effects (DFE) describes the spectrum of effects of new mutations that can occur along a genome, and is therefore of vital interest in evolutionary biology. Recent work has uncovered striking similarities in the DFE between closely related species, prompting us to ask whether there is variation in the DFE among populations of the same species, or among species with different degrees of divergence, i.e., whether there is variation in the DFE at different levels of evolution. Using exome capture data from six tree species sampled across Europe we characterised the DFE for multiple species, and for each species, multiple populations, and investigated the factors potentially influencing the DFE, such as demography, population divergence and genetic background. We find statistical support for there being variation in the DFE at the species level, even among relatively closely related species. However, we find very little difference at the population level, suggesting that differences in the DFE are primarily driven by deep features of species biology, and that evolutionarily recent events, such as demographic changes and local adaptation, have little impact

Centrality evolution of the charged-particle pseudorapidity density over a broad pseudorapidity range in Pb-Pb collisions at root s(NN)=2.76TeV

Peer reviewe

Testamentary Formalities in Scotland

Measurements of cross sections of inelastic and diffractive processes in proton--proton collisions at LHC energies were carried out with the ALICE detector. The fractions of diffractive processes in inelastic collisions were determined from a study of gaps in charged particle pseudorapidity distributions: for single diffraction (diffractive mass $M_X 3$) $\sigma_{\rm DD}/\sigma_{\rm INEL} = 0.11 \pm 0.03, 0.12 \pm 0.05$, and $0.12^{+0.05}_{-0.04}$, respectively at $\sqrt{s} = 0.9, 2.76$, and 7 TeV. To measure the inelastic cross section, beam properties were determined with van der Meer scans, and, using a simulation of diffraction adjusted to data, the following values were obtained: $\sigma_{\rm INEL} = 62.8^{+2.4}_{-4.0} (model) \pm 1.2 (lumi)$ mb at $\sqrt{s} =$ 2.76 TeV and $73.2^{+2.0}_{-4.6} (model) \pm 2.6 (lumi)$ mb at $\sqrt{s}$ = 7 TeV. The single- and double-diffractive cross sections were calculated combining relative rates of diffraction with inelastic cross sections. The results are compared to previous measurements at proton--antiproton and proton--proton colliders at lower energies, to measurements by other experiments at the LHC, and to theoretical models

Recommendations for the management of pancreatic cancer type adenocarcinoma. A consensus statement reached during the 2015 Latin American Symposium on Gastroenterological Oncology

Pancreatic cancer is a malignancy of great impact in developed countries and is having an increasing impact in Latin America. Incidence and mortality rates are similar for this cancer. This is an important reason to offer to the patients the best treatments available. During the Latin American Symposium of Gastroenterology Oncology (SLAGO) held in Vina del Mar, Chile, in April 2015, a multidisciplinary group of specialists in the field met to discuss about this disease. The main conclusions of this meeting, where practitioners from most of Latin American countries participated, are listed in this consensus that seek to serve as a guide for better decision making for patients with pancreatic cancer in Latin Americ

Reproducibility and accuracy of microscale thermophoresis in the NanoTemper Monolith: a multi laboratory benchmark study (European Biophysics Journal, (2021), 50, 3-4, (411-427), 10.1007/s00249-021-01532-6)

Publisher Copyright: © The Author(s) 2021.The article “Reproducibility and accuracy of microscale thermophoresis in the NanoTemper Monolith: a multi laboratory benchmark study” written by López-Méndez, B., Baron, B., Brautigam, C. A., Jowitt, T. A., Knauer, S. H., Uebel, S., Williams, M. A., Sedivy, A., Abian, O., Abreu, C., Adamczyk, M., Bal, W., Berger, S., Buell, A. K., Carolis, C., Daviter, T., Fish, A., Garcia-Alai, M., Guenther, C., Hamacek, J., Holková, J., Houser, J., Johnson, C., Kelly, S., Leech, A., Mas, C., Matulis, D., McLaughlin, S. H., Montserret, R., Nasreddine, R., Nehmé, R., Nguyen, Q., Ortega-Alarcón, D., Perez, K., Pirc, K., Piszczek, G., Podobnik, M., Rodrigo, N., Rokov-Plavec, J., Schaefer, S., Sharpe, T., Southall, J., Staunton, D., Tavares, P., Vanek, O., Weyand, M., Wu, D. was originally published Online First without Open Access. After publication in volume 50, issue 3–4, pages 411–427 the author decided to opt for Open Choice and to make the article an Open Access publication. Therefore, the copyright of the article has been changed topublishersversionpublishe