A new locality for the endangered species Ceratocapnos heterocarpa Durieu (Papaveraceae) to Spain and its syntaxonomical characterization.

Una nueva localidad para la especie amenazada Ceratocapnos heterocarpa Durieu (Papaveraceae) para España y su caracterización sintaxonómicaKey words. Chorology, new record, Ceratocapnos heterocarpa, Spain, phytosociology.Palabras clave. Corología, nueva cita, Cetarocapnos heterocarpa, España, fitosociología

Drivers and Impact of ICT adoptation in the European Transport and Logistic Services

The availability of high quality transport and logistics services (TLS) is of paramount importance for growth and competitiveness of the European economy. The objective of this paper is to describe, from the continuous innovation perspective, how companies in this industry use ICT for conducting business and to assess the impact of this development for firms and for the industry as a whole. Using the SCP model and the bi-directional relationships of its elements the paper identifies the links between ICT adoption and innovation dynamics. Moreover, the analysis allows identifying the driving forces of ICT and its impact on selected business dimensions. On the driver’s side, there are three points that are worth mentioning: increasing market competition, the relationships of firms interacting with each other and the availability and quality of complementary assets such as employee skills and IT know-how. On the impacts’ side, firms advanced in terms of ICT usage are more likely to have outsourced business activities. Finally, a set of recommendations on how to further improve the continuous innovation factors in the TLS industry is presented

Aportaciones a la flora vascular de la provincia de Córdoba, III (Andalucía, España)

En el presente estudio corológico se aportan 33 taxones que son raros o suponen novedad para alguna comarca de Córdoba (Andalucía, España) o para toda la provincia. Las especies que son novedad provincial son: Cotoneaster pannosus Franch., Cotula australis (Sieber ex Spreng.) Hook.f., Cyperus involucratus Rottb., Leucaena leucocephala (Lam.) de Wit, Narcissus × hervasii Barra & Ureña, Podranea ricasoliana (Tanf.) Sprague y Prunus erasifera Ehrh.Thirty-three taxa are recorded as rare and new localities either in some areas or the whole province of Cordoba (Andalusia, Spain). The species that are recorded for the first time to the province of Cordoba are: Cotoneaster pannosus Franch., Cotula australis (Sieber ex Spreng.) Hook.f., Cyperus involucratus Rottb., Leucaena leucocephala (Lam.) de Wit, Narcissus × hervasii Barra & Ureña, Podranea ricasoliana (Tanf.) Sprague and Prunus cerasifera Ehrh

Risk factors for ≥high-grade anal intraepithelial lesions in MSM living with HIV and the response to topical and surgical treatments

The authors are grateful to MercedesA ´ lvarez Romero for coordinating patients and drawing blood samples and to Marina Gutie´rrez and Rodrigo Lo´pez of the Pathology Department for processing samples. The authors are grateful to the participating patients.Background The objective of this study in MSM living with HIV was to determine the incidence of HSIL and ASCC, related factors, and the response to treatment. Patients and methods Data were gathered in 405 consecutive HIV-infected MSM (May 2010-December 2018) at baseline and annually on: sexual behavior, anal cytology, and HPV PCR and/or high-resolution anoscopy results. They could choose mucosectomy with electric scalpel (from May 2010) or self-administration of 5% imiquimod 3 times weekly for 16 weeks (from November 2013). A multivariate logistic regression model was developed for ≥HSIL-related factors using a step-wise approach to select variables, with a significance level of 0.05 for entry and 0.10 for exit, applying the Hosmer-Lemeshow test to assess the goodness of fit. Results The study included 405 patients with a mean age of 36.2 years; 56.7% had bachelor´s degree, and 52.8% were smokers. They had a mean of 1 (IQR 1–7) sexual partner in the previous 12 months, median time since HIV diagnosis of 2 years, and mean CD4 nadir of 367.9 cells/uL; 86.7% were receiving ART, the mean CD4 level was 689.6 cells/uL, mean CD4/CD8 ratio was 0.77, and 85.9% of patients were undetectable. Incidence rates were 30.86/1,000 patient-years for ≥high squamous intraepithelial lesion (HSIL) and 81.22/100,000 for anal squamous cell carcinoma (ASCC). The ≥HSIL incidence significantly decreased from 42.9% (9/21) in 2010 to 4.1% (10/254) in 2018 (p = 0.034). ≥HSIL risk factors were infection with HPV 11 (OR 3.81; 95%CI 1.76–8.24), HPV 16 (OR 2.69, 95%CI 1.22–5.99), HPV 18 (OR 2.73, 95%CI 1.01–7.36), HPV 53 (OR 2.97, 95%CI 1.002–8.79); HPV 61 (OR 11.88, 95%CI 3.67–38.53); HPV 68 (OR 2.44, CI 95% 1.03–5.8); low CD4 nadir (OR1.002; 95%CI 1–1.004) and history of AIDS (OR 2.373, CI 95% 1.009–5.577). Among HSIL-positive patients, the response rate was higher after imiquimod than after surgical excision (96.7% vs 73.3%, p = 0.009) and there were fewer re-treatments (2.7% vs 23.4%, p = 0.02) and adverse events (2.7% vs 100%, p = 0.046); none developed ASCC. Conclusions HSIL screening and treatment programs reduce the incidence of HSIL, which is related to chronic HPV infection and poor immunological status. Self-administration of 5% imiquimod as first-line treatment of HSIL is more effective than surgery in HIV+ MSM

ART is key to clearing oncogenic HPV genotypes (HR-HPV) in anal mucosa of HIV-positive MSM

Background: Anal squamous cell carcinoma (ASCC) is one of the most frequent non-AIDS-defining neoplasias in HIV patients, mainly in MSM, and it has been associated with chronic infection with high-risk human papilloma virus (HR-HPV). Our main objective was to determine HR-HPV clearance and acquisition rates and related factors and their relationship with the incidence of HSILs and ASCC in anal mucosa of HIV+ MSM. Patients and methods: The study included consecutive HIV-infected MSM between May 2010 and December 2018. Data were gathered at baseline and annually on their sexual behavior, CD4 and CD8 levels, plasma HIV viral load, and results of anal cytology, HPV PCR, and high-resolution anoscopy. Results: Out of the 405 patients studied, 34.9% of patients cleared oncogenic genotypes (IQR: 37-69) within 49 months, and 42.9% acquired new genotypes within 36 months (IQR:12-60). In multivariate analysis, clearance was only significantly influenced by the duration of antiretroviral therapy (ART) (OR: 1.016, 95% CI 1.003-1.030). The incidence of HSILs was 30.86/1,000 patient-years and that of ASCC was 81.22/100,000 patient-years; these incidences were not influenced by the acquisition (acquired: 14.9% vs. non-acquired: 10.4%; p = 0.238) or clearance (cleared 11.4% vs. non-cleared: 13.2%; p = 0.662) rates of these viruses. Conclusions: The duration of ART appears to positively affect oncogenic genotype clearance in the anal mucosa of HIV+ MSM, although this clearance does not affect the incidence of HSILs or ASCC. The reduction in HSIL+ rate observed in our patients may be attributable to the bundle of measures adopted at our center

Aportaciones a la flora vascular de la provincia de Córdoba, II (Andalucía, España)

En el presente estudio corológico se aportan 25 taxones que son raros o suponen novedad para alguna comarca o toda la provincia de Córdoba (Andalucía, España). Los taxones más interesantes son Campanula decumbens subsp. baetica Cano-Maqueda & Talavera, Narcissus × susannae Fern. Casas y Plumbago auriculata Lam., ya que son citados por primera vez para esta provincia.Twenty-five taxa are recorded as rare and new localities either in some areas or the whole province of Cordoba (Andalusia, Spain). Campanula decumbens subsp. baetica Cano-Maqueda & Talavera, Narcissus × susannae Fern. Casas and Plumbago auriculata Lam. are the most interesting taxa found, being the first record for this province

Defining the first bona fide cell model for SMARCA4-deficient, undifferentiated tumor

The World Health Organization’s tumor classification guidelines are frequently updated and renewed as knowledge of cancer biology advances. For instance, in 2021, a novel lung tumor subtype named SMARCA4-deficient, undifferentiated tumor (SMARCA4-dUT, code 8044/3) was included. To date, there is no defined cell model for SMARCA4-dUT that could be used to help thoracic clinicians and researchers in the study of this newly defined tumor type. As this tumor type was recently described, it is feasible that some cell models formerly classified as lung adenocarcinoma (LUAD) could now be better classified as SMARCA4-dUT. Thus, in this work, we aimed to identify a bona fide cell model for the experimental study of SMARCA4-dUT. We compared the differential expression profiles of 36 LUAD-annotated cell lines and 38 cell lines defined as rhabdoid in repositories. These comparative results were integrated with the mutation and expression profiles of the SWI/SNF complex members, and they were surveyed for the presence of the SMARCA4-dUT markers SOX2, SALL4, and CD34, measured by RTqPCR and western blotting. Finally, the cell line with the paradigmatic SMARCA4-dUT markers was engrafted into immunocompromised mice to assess the histological morphology of the formed tumors and compare them with those formed by a bona fide LUAD cancer cell line. NCI-H522, formerly classified as LUAD, displayed expression profiles nearer to rhabdoid tumors than LUAD tumors. Furthermore, NCI-H522 has most of the paradigmatic features of SMARCA4-dUT: hemizygous inactivating mutation of SMARCA4, severe SMARCA2 downregulation, and high-level expression of stem cell markers SOX2 and SALL4. In addition, the engrafted tumors of NCI-H522 did not display a typical differentiated glandular structure as other bona fide LUAD cell lines (A549) do but had rather a largely undifferentiated morphology, characteristic of SMARCA4-dUT. Thus, we propose the NCI-H522 as the first bona fide cell line model of SMARCA4-dUT.Spanish Ministry of Science and Innovation (PID2021-126111OB-I00)Junta de Andalucía (PIGE-0213-2020, PI-0203-2022)University of Granada (B-CTS-480-UGR20)The Fundaci on Científica Asociaci on Española Contra el Cáncer (LAB-AECC-2018)FPU17/01258 fellowshipPrograma Operativo de Empleo Juvenil y de la Iniciativa de Empleo Juvenil (#04/2022-05)Grant from the Scientific Foundation of the Spanish Association Against Cancer in Granada (#PRDGR21428SAN

Recent advances in pharmaceutical sciences V

Reproducció del llibre publicat a: http://www.trnres.com/ebookcontents.php?id=249This E-book is the fifth volume of a series that compiles contributions from different areas of the multidisciplinary field of Pharmaceutical Sciences. The E-book consists of 11 chapters that cover the areas of organic chemistry, health and environmental management, plant physiology, food science, toxicology, botany, parasitology, physiology, biochemistry and molecular biology, microbiology, and pharmacology