2,367 research outputs found
Finite state stochastic games - Existence theorems and computational procedures
Existence theorems and computational procedures for finite state stochastic game
Characterization of gsp-Mediated Growth Hormone Excess in the Context of McCune-Albright Syndrome
McCune-Albright syndrome (MAS) is a disorder characterized by the triad of café-au-lait skin pigmentation, polyostotic fibrous dysplasia of bone, and hyperfunctioning endocrinopathies, including GH excess. The molecular etiology of the disease is postzygotic activating mutations of the GNAS1 gene product, Gsα. The term gsp oncogene has been assigned to these mutations due to their association with certain neoplasms. The aim of this study was to estimate the prevalence of GH excess in MAS, characterize the clinical and endocrine manifestations, and describe the response to treatment. Fifty-eight patients with MAS were screened, and 22 with stigmata of acromegaly and/or elevated GH or IGF-I underwent oral glucose tolerance testing. Twelve patients (21%) had GH excess, based on failure to suppress serum GH on oral glucose tolerance test, and underwent a TRH test, serial GH sampling from 2000-0800 h, and magnetic resonance imaging of the sella. We found that vision and hearing deficits were more common in patients with GH excess (4 of 12, 33%) than those without (2 of 56, 4%). Of interest, patients with a history of precocious puberty and GH excess who had reached skeletal maturity achieved normal adult height despite a history of early epiphyseal fusion. All 9 patients tested had an increase in serum GH after TRH, 11 of 12 (92%) had hyperprolactinemia, and all 8 tested had detectable or elevated nighttime GH levels. Pituitary adenoma was detected in 4 of 12 (33%) patients. All patients with elevated IGF-I levels were treated with cabergoline (7 patients), long-acting octreotide (LAO; 8 patients), or a combination of cabergoline and LAO (4 patients). In six of the seven patients (86%) treated with cabergoline, serum IGF-I decreased, but not to the normal range. In the eight patients treated with LAO alone, IGF-I decreased, and, in four, returned to the normal range. The remaining 4 patients were treated with a combination of cabergoline and LAO. For them, symptoms of GH excess diminished, and IGF-I decreased further, but did not enter the normal range. GH excess is common in MAS and results in a distinct clinical phenotype characterized by inappropriately normal stature, TRH responsiveness, prolactin cosecretion, small or absent pituitary tumors, a consistent but inadequate response to treatment with cabergoline, and an intermediate response to LAO
CONVERGENCE OF AMERICAN OPTION VALUES FROM DISCRETE- TO CONTINUOUS-TIME FINANCIAL MODELS 1
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/75553/1/j.1467-9965.1994.tb00059.x.pd
Myeloablation with diaziquone: in vitro assessment
The promising antineoplastic agent diaziquone is associated with prolonged aplasia and rare instances of bone marrow necrosis, but only mild extramedullary toxicity. To explore the drug's potential as a myeloablative agent prior to bone marrow transplantation, we compared its effects on hematopoietic versus marrow stromal cells. After short-term (one to six hours) or prolonged (three to seven days) exposure to the drug, marrow was assayed for hematopoietic (CFU-Mix, BFU-E, CFU-GM) and stromal (CFU-F) colony-forming cells and studied in long-term marrow culture (LTMC). One- and three-hour treatments produced little cytotoxicity, even at 5000 ng/mL. After six-hour treatments with this dose, marrow was depleted of CFU-Mix, BFU-E, and CFU-GM, but produced CFU-GM in LTMCs, indicating an ongoing input of CFU-GM from a surviving pre-CFU-Mix population. In contrast, elimination of the latter may be inferred from the absence of CFU-GM in LTMCs exposed for three to seven days to diaziquone at only 150 ng/mL. Under these conditions, CFU-F recovery was 40% and adherent stromal layers in LTMCs were similar to untreated controls regarding rate of development and cellular composition. Our in vitro pre-CFU-Mix-ablative regimen correlates with clinical data that show prolonged but reversible myelosuppression at steady-state diaziquone plasma levels of 101 +/- 10 ng/mL (mean +/- standard error of mean) during 7-day constant infusions
Self-Averaging Scaling Limits of Two-Frequency Wigner Distribution for Random Paraxial Waves
Two-frequency Wigner distribution is introduced to capture the asymptotic
behavior of the space-frequency correlation of paraxial waves in the radiative
transfer limits. The scaling limits give rises to deterministic transport-like
equations. Depending on the ratio of the wavelength to the correlation length
the limiting equation is either a Boltzmann-like integral equation or a
Fokker-Planck-like differential equation in the phase space. The solutions to
these equations have a probabilistic representation which can be simulated by
Monte Carlo method. When the medium fluctuates more rapidly in the longitudinal
direction, the corresponding Fokker-Planck-like equation can be solved exactly.Comment: typos correcte
Quadratic optimal functional quantization of stochastic processes and numerical applications
In this paper, we present an overview of the recent developments of
functional quantization of stochastic processes, with an emphasis on the
quadratic case. Functional quantization is a way to approximate a process,
viewed as a Hilbert-valued random variable, using a nearest neighbour
projection on a finite codebook. A special emphasis is made on the
computational aspects and the numerical applications, in particular the pricing
of some path-dependent European options.Comment: 41 page
A Quantum Langevin Formulation of Risk-Sensitive Optimal Control
In this paper we formulate a risk-sensitive optimal control problem for
continuously monitored open quantum systems modelled by quantum Langevin
equations. The optimal controller is expressed in terms of a modified
conditional state, which we call a risk-sensitive state, that represents
measurement knowledge tempered by the control purpose. One of the two
components of the optimal controller is dynamic, a filter that computes the
risk-sensitive state.
The second component is an optimal control feedback function that is found by
solving the dynamic programming equation. The optimal controller can be
implemented using classical electronics.
The ideas are illustrated using an example of feedback control of a two-level
atom
Effect of time-correlation of input patterns on the convergence of on-line learning
We studied the effects of time correlation of subsequent patterns on the
convergence of on-line learning by a feedforward neural network with
backpropagation algorithm. By using chaotic time series as sequences of
correlated patterns, we found that the unexpected scaling of converging time
with learning parameter emerges when time-correlated patterns accelerate
learning process.Comment: 8 pages(Revtex), 5 figure
Gate complexity using dynamic programming
The relationship between efficient quantum gate synthesis and control theory has been a topic of recent interest in the quantum computing literature. Motivated by this work, we describe how the dynamic programming technique from optimal control may be used in principle to determine gate complexity and for the optimal synthesis of quantum circuits. We illustrate the dynamic programming methodology using a simple example on the Lie group SU(2)
Theodicy and End-of-Life Care
Acknowledgments The section on Islamic perspective is contributed by information provided by Imranali Panjwani, Tutor in Theology & Religious Studies, King's College London.Peer reviewedPublisher PD
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