Lack of direct evidence for a functional role of voltage-operated calcium channels in juxtaglomerular cells

In this study we have examined the role of voltage-gated calcium channels in the regulation of calcium in juxtaglomerular cells. Using a combination of patch-clamp and single-cell calcium measurement we obtained evidence neither for voltage-operated calcium currents nor for changes of the intracellular calcium concentration upon acute depolarizations of the cell membrane. Increases of the extracellular concentration of potassium to 80 mmol/l depolarized the juxtaglomerular cells close to the potassium equilibrium potential, but did not alter the intracellular calcium concentration neither in patch-clamped nor in intact Furaester-loaded cells. Moreover, basal renin secretion from a preparation enriched in mouse juxtaglomerular cells and from rat glomeruli with attached juxtaglomerular cells was not inhibited when extracellular potassium was isoosmotically increased to 56 mmol/l. In mouse kidney slices, however, depolarizing potassium concentrations caused a delayed inhibition at 56 mmol/l and a delayed stimulation of renin secretion at 110 mmol/l. Taken together, our study does not provide direct evidence for a role of voltage-activated calcium channels in the regulation of calcium and renin secretion in renal juxtaglomerular cells

On the understanding of pulsations in the atmosphere of roAp stars: phase diversity and false nodes

Studies based on high-resolution spectroscopic data of rapidly oscillating Ap stars show a surprising diversity of pulsation behavior in the atmospheric layers, pointing, in particular, to the co-existence of running and standing waves. The correct interpretation of these data requires a careful modelling of pulsations in these magnetic stars. In light of this, in this work we present a theoretical analysis of pulsations in roAp stars, taking into account the direct influence of the magnetic field. We derive approximate analytical solutions for the displacement components parallel and perpendicular to the direction of the magnetic field, that are appropriate to the outermost layer. From these, we determine the expression for the theoretical radial velocity for an observer at a general position, and compute the corresponding pulsation amplitude and phase as function of height in the atmosphere. We show that the integral for the radial velocity has contributions from three different types of wave solutions, namely, running waves, evanescent waves, and standing waves of nearly constant amplitude. We then consider a number of case studies to illustrate the origin of the different pulsational behaviour that is found in the observations. Concerning pulsation amplitude, we find that it generally increases with atmospheric height. Pulsation phase, however, shows a diversity of behaviours, including phases that are constant, increasing, or decreasing with atmospheric height. Finally, we show that there are situations in which the pulsation amplitude goes through a zero, accompanied by a phase jumps of $\pi$, and argue that such behaviour does not correspond to a pulsation node in the outermost layers of the star, but rather to a visual effect, resulting from the observers inability to resolve the stellar surface.Comment: 21 pages, 25 figure

New measurements of magnetic fields of roAp stars with FORS1 at the VLT

Magnetic fields play a key role in the pulsations of rapidly oscillating Ap (roAp) stars since they are a necessary ingredient of all pulsation excitation mechanisms proposed so far. This implies that the proper understanding of the seismological behaviour of the roAp stars requires knowledge of their magnetic fields. However, the magnetic fields of the roAp stars are not well studied. Here we present new results of measurements of the mean longitudinal field of 14 roAp stars obtained from low resolution spectropolarimetry with FORS1 at the VLT.Comment: 5 pages, accepted for publication in A&

A stochastic epidemiological model and a deterministic limit for BitTorrent-like peer-to-peer file-sharing networks

In this paper, we propose a stochastic model for a file-sharing peer-to-peer network which resembles the popular BitTorrent system: large files are split into chunks and a peer can download or swap from another peer only one chunk at a time. We prove that the fluid limits of a scaled Markov model of this system are of the coagulation form, special cases of which are well-known epidemiological (SIR) models. In addition, Lyapunov stability and settling-time results are explored. We derive conditions under which the BitTorrent incentives under consideration result in shorter mean file-acquisition times for peers compared to client-server (single chunk) systems. Finally, a diffusion approximation is given and some open questions are discussed.Comment: 25 pages, 6 figure

The Effect of Use and Access on Citations

It has been shown (S. Lawrence, 2001, Nature, 411, 521) that journal articles which have been posted without charge on the internet are more heavily cited than those which have not been. Using data from the NASA Astrophysics Data System (ads.harvard.edu) and from the ArXiv e-print archive at Cornell University (arXiv.org) we examine the causes of this effect.Comment: Accepted for publication in Information Processing & Management, special issue on scientometric

The Nainital-Cape Survey -- II:Report for pulsation in five chemically peculiar A-type stars and presentation of 140 null results

To search photometric variability in chemically peculiar A type stars in the northern hemisphere. High-speed photometric observations of Ap and Am star candidates have been carried out from ARIES (Manora Peak, Nainital) using a three-channel fast photometer attached to the ARIES 104-cm Sampurnanand telescope. This paper presents three new variables: HD 113878, HD 118660 and HD 207561. During the time span of the survey (1999 December to 2004 January) pulsations of the $\delta$ Sct type were also found for the two evolved Am stars HD 102480 and HD 98851, as reported in Joshi et al. (2002, 2003). Additionally, we present 140 null results of the survey for this time span. The star HD 113878 pulsates with a period of 2.31 hr, which is typical of $\delta$ Sct stars. HD 118660 exhibits multi-periodic variability with a prominent period of nearly 1 hr. These periods need to be investigated and make HD 118660 a particularly interesting target for further observations. For HD 207561, a star classified as Am, a probable pulsation with a period of 6 min was found in the light curves obtained on two consecutive nights. Both HD 102480 and HD 98851 exhibit unusual alternating high and low amplitude maxima, with a period ratio of 2:1. The analysis of the null results confirms the photometric quality of the NainitalComment: 14 pages, 13 figures, Accepted for publication in A&

The Mean Drift: Tailoring the Mean Field Theory of Markov Processes for Real-World Applications

The statement of the mean field approximation theorem in the mean field theory of Markov processes particularly targets the behaviour of population processes with an unbounded number of agents. However, in most real-world engineering applications one faces the problem of analysing middle-sized systems in which the number of agents is bounded. In this paper we build on previous work in this area and introduce the mean drift. We present the concept of population processes and the conditions under which the approximation theorems apply, and then show how the mean drift is derived through a systematic application of the propagation of chaos. We then use the mean drift to construct a new set of ordinary differential equations which address the analysis of population processes with an arbitrary size