1 research outputs found
Rhodium-Catalyzed Asymmetric Addition of Arylboronic Acids to β‑Nitroolefins: Formal Synthesis of (<i>S</i>)‑SKF 38393
An efficient enantioselective addition of an array of arylboronic
acids to various β-nitrostyrenes catalyzed by a novel and reactive
rhodium–diene catalyst (S/C up to 1000) was developed, providing
β,β-diarylnitroethanes in good to high yields (62–99%)
with excellent enantioselectivities (85–97% ee). The method
was extended to 2-heteroarylnitroolefins and 2-alkylnitroolefins similarly
providing the desired products with high enantioselectivities and
yields. The usefulness of this method was demonstrated in the formal
synthesis of the enantiomer of the dopamine receptor agonist and antagonist,
SKF 38393