Collective Excitations of (154)Sm nucleus at FEL{gamma}+LHC Collider

The production of collective excitations of the (154)Sm at FEL{gamma}+LHC collider is investigated. We show that this machine will be a powerful tool for investigation of high energy level excitations.Comment: 6 pages, 1 figure, 4 table

Влияние лецитина и казеина на спектр антимикробной активности бактериоцинов молочнокислых бактерий, изолированных из азербайджанских сыров

Изучено влияние лецитина и казеина на спектр антимикробной активности бактериоцинов, выделенных из штаммов Lactobacillus paracasei spp. paracasei BN ATS 8w, Enterococcus faecium А5 и Lactobacillus rhamnosus FAZ 16m. В качестве пассивной культуры использованы Lactobacillus bulgaricus 340, Listeria innocua СIP 80.11, Escherichia coli ATCC 23355, Enterococcus faecalis ATCC 1.144. При исследуемых концентрациях лецитин и казеин отрицательно влияли на активность бактериоцинов. Эти факторы входят в состав большинства ферментированных продуктов

The Effect of the Pairing Interaction on the Energies of Isobar Analog Resonances in 112−124^{112-124}Sb and Isospin Admixture in 100−124^{100-124}Sn Isotopes

In the present study, the effect of the pairing interaction and the isovector correlation between nucleons on the properties of the isobar analog resonances (IAR) in $^{112-124}$Sb isotopes and the isospin admixture in $^{100-124}$Sn isotopes is investigated within the framework of the quasiparticle random phase approximation (QRPA). The form of the interaction strength parameter is related to the shell model potential by restoring the isotopic invariance of the nuclear part of the total Hamiltonian. In this respect, the isospin admixtures in the $^{100-124}$Sn isotopes are calculated, and the dependence of the differential cross section and the volume integral $J_{F}$ for the Sn($^{3}$He,t)Sb reactions at E($^{3}$He)$=200$ MeV occurring by the excitation of IAR on mass number A is examined. Our results show that the calculated value for the isospin mixing in the $^{100}$Sn isotope is in good agreement with Colo et al.'s estimates $(4-5$, and the obtained values for the volume integral change within the error range of the value reported by Fujiwara et al. (53$\pm$5 MeV fm$^{3}$). Moreover, it is concluded that although the differential cross section of the isobar analog resonance for the ($^{3}$He,t) reactions is not sensitive to pairing correlations between nucleons, a considerable effect on the isospin admixtures in $N\approx Z$ isotopes can be seen with the presence of these correlations.Comment: 16 pages, 5 EPS figures and 2 tables, Late

Errors in chromosome segregation during oogenesis and early embryogenesis

Errors in chromosome segregation occurring during human oogenesis and early embryogenesis are very common. Meiotic chromosome development during oogenesis is subdivided into three distinct phases. The crucial events, including meiotic chromosome pairing and recombination, take place from around 11 weeks until birth. Oogenesis is then arrested until ovulation, when the first meiotic division takes place, with the second meiotic division not completed until after fertilization. It is generally accepted that most aneuploid fetal conditions, such as trisomy 21 Down syndrome, are due to maternal chromosome segregation errors. The underlying reasons are not yet fully understood. It is also clear that superimposed on the maternal meiotic chromosome segregation errors, there are a large number of mitotic errors taking place post-zygotically during the first few cell divisions in the embryo. In this chapter, we summarise current knowledge of errors in chromosome segregation during oogenesis and early embryogenesis, with special reference to the clinical implications for successful assisted reproduction

A pilot study of application of the Stroke Riskometer mobile app for assessment of the course and clinical outcomes of COVID-19 among hospitalised patients

Early determination of COVID-19 severity and health outcomes could facilitate better treatment of patients. Different methods and tools have been developed for predicting outcomes of COVID-19, but they are difficult to use in routine clinical practice. Methods: We conducted a prospective cohort study of inpatients aged 20-92 years, diagnosed with COVID-19 to determine whether their individual 5-year absolute risk of stroke at the time of hospital admission predicts the course of COVID-19 severity and mortality. The risk of stroke was determined by the Stroke Riskometer mobile application. Results: We examined 385 patients hospitalised with COVID-19 (median age 61 years). The participants were categorised based on COVID-19 severity: 271 (70.4%) to the “Not severe” and 114 (29.6%) to the “Severe” groups. The median risk of stroke the next day after hospitalisation was significantly higher among patients in the Severe group (2.83 [95% CI 2.35-4.68]) vs the Not severe group (1.11 [95% CI 1.00–1.29]). The median risk of stroke and median systolic blood pressure (SBP) were significantly higher among non-survivors (12.04 [95% CI 2.73-21.19]) and (150 [95% CI 140-170]) vs survivors (1.31 [95% CI 1.14-1.52]), 134 [95% CI 130-135]), respectively. Those who spent more than 2.5 hours a week on physical activity were 3.1 times more likely to survive from COVID-19. Those who consumed more than one standard alcohol drink a day, or suffered with atrial fibrillation, or had poor memory were 2.5, 2.3, and 2.6 times more likely not to survive from COVID-19, respectively. Conclusions: High risk of stroke, physical inactivity, alcohol intake, high SBP, and atrial fibrillation are associated with severity and mortality of COVID-19. Our findings suggest that the Stroke Riskometer app could be used as a simple predictive tool of COVID-19 severity and mortality

Биохимические основы визуализации при позитронной эмиссионной томографии в онкологии. Часть 2

This article provides an overview of the main literature data of biochemical basics and the clinical application of positron emission tomography, one of the promising technologies of radiation imaging in oncology.In the current part we discuss in detail the biokinetics of radiopharmaceuticals used to visualize various groups of tumor cells receptors. These include angiogenesis markers - RGD peptides, ligands for somatostatin receptors, agents for sex hormone imaging, ligands for prostate-specific membrane antigen and to activating EGFR mutant kinase. It contains results of studies that were dedicated to search for optimal modifications of these radiopharmaceuticals to increase diagnostic efficiency, their comparative analysis is carried out, the results of their use in cancer research and development prospects in this industry are highlighted.Настоящая статья содержит обзор основных литературных данных, посвященных биохимическим основам и клиническому применению позитронной эмиссионной томографии – одной из перспективных технологий лучевой визуализации в онкологии.В данной части подробно рассмотрены особенности биокинетики радиофармацевтических препаратов, применяемых для визуализации различных групп рецепторов, представленных в опухолевых клетках. К ним относятся маркеры ангиогенеза – RGD-пептиды, лиганды к рецепторам соматостатина, агенты для визуализации рецепторов к половым гормонам, лиганды к простатспецифическому мембранному антигену и киназе, активируемой мутацией EGFR. Представлены результаты исследований по поиску оптимальных модификаций этих радиофармацевтических препаратов для повышения диагностической эффективности, проведен их сравнительный анализ, освещены результаты их применения у пациентов онкологического профиля и перспективы развития в данной отрасли