TESS Giants Transiting Giants. I.: A Noninflated Hot Jupiter Orbiting a Massive Subgiant

While the population of confirmed exoplanets continues to grow, the sample of confirmed transiting planets around evolved stars is still limited. We present the discovery and confirmation of a hot Jupiter orbiting TOI-2184 (TIC 176956893), a massive evolved subgiant (M ∗ = 1.53 ± 0.12 M o˙, R ∗ = 2.90 ± 0.14 R o˙) in the Transiting Exoplanet Survey Satellite (TESS) Southern Continuous Viewing Zone. The planet was flagged as a false positive by the TESS Quick-Look Pipeline due to periodic systematics introducing a spurious depth difference between even and odd transits. Using a new pipeline to remove background scattered light in TESS Full Frame Image data, we combine space-based TESS photometry, ground-based photometry, and ground-based radial velocity measurements to report a planet radius of R p = 1.017 ± 0.051 R J and mass of M p = 0.65 ± 0.16 M J . For a planet so close to its star, the mass and radius of TOI-2184b are unusually well matched to those of Jupiter. We find that the radius of TOI-2184b is smaller than theoretically predicted based on its mass and incident flux, providing a valuable new constraint on the timescale of post-main-sequence planet inflation. The discovery of TOI-2184b demonstrates the feasibility of detecting planets around faint (TESS magnitude > 12) post-main-sequence stars and suggests that many more similar systems are waiting to be detected in the TESS FFIs, whose confirmation may elucidate the final stages of planetary system evolution

The EASI project--improving the effectiveness and quality of image-guided surgery

In recent years, advances in computer technology and a significant increase in the accuracy of medical imaging have made it possible to develop systems that can assist the clinician in diagnosis, planning, and treatment. This paper deals with an area that is generally referred to as computer-assisted surgery, image-directed surgery, or image-guided surgery. We report the research, development, and clinical validation performed since January 1996 in the European Applications in Surgical Interventions (EASI) project, which is funded by the European Commission in their "4th Framework Telematics Applications for Health" program. The goal of this project is the improvement of the effectiveness and quality of image-guided neurosurgery of the brain and image-guided vascular surgery of abdominal aortic aneurysms, while at the same time reducing patient risks and overall cost. We have developed advanced prototype systems for preoperative surgical planning and intraoperative surgical navigation, and we have extensively clinically validated these systems. The prototype systems and the clinical validation results are described in this paper.status: publishe

Public Regulation of the Religious Use of Land

Notch2 and B cell antigen receptor (BCR) signaling determine whether transitional B cells become marginal zone B (MZB) or follicular B (FoB) cells in the spleen, but it is unknown how these pathways are related. We generated Taok3 -/- mice, lacking the serine/threonine kinase Taok3, and found cell-intrinsic defects in the development of MZB but not FoB cells. Type 1 transitional (T1) B cells required Taok3 to rapidly respond to ligation by the Notch ligand Delta-like 1. BCR ligation by endogenous or exogenous ligands induced the surface expression of the metalloproteinase ADAM10 on T1 B cells in a Taok3-dependent manner. T1 B cells expressing surface ADAM10 were committed to becoming MZB cells in vivo, whereas T1 B cells lacking expression of ADAM10 were not. Thus, during positive selection in the spleen, BCR signaling causes immature T1 B cells to become receptive to Notch ligands via Taok3-mediated surface expression of ADAM10