A dynamic global model for planktonic foraminifera

International audienceSeasonal changes in the flux of planktonic foraminifera have to be understood to interpret corresponding proxy-based reconstructions. To study the seasonal cycle of planktonic foraminifera species we developed a numerical model of species concentration (PLAFOM). This model is forced with a global hydrographic dataset (e.g. temperature, mixed layer depth) and with biological information taken from an ecosystem model (e.g. "food type", zooplankton abundance) to predict monthly concentrations of the most common planktonic foraminifera species used for proxies: N. pachyderma (sinistral and dextral varieties), G. bulloides, G. ruber (white variety) and G. sacculifer. The sensitivity of each species with respect to temperature (optimal temperature and range of tolerance) is derived from sediment-trap studies. Overall, the spatial distribution patterns of most of the species are comparable to core-top data. N. pachyderma (sin.) is limited to polar regions, N. pachyderma (dex.) and G. bulloides are the most common species in high productivity zones like upwelling areas, while G. ruber and G. sacculifer are more abundant in tropical and subtropical oligotrophic waters. Modeled seasonal variation match well with sediment-trap records in most of the locations for N. pachyderma (sin), N. pachyderma (dex.) and G. bulloides. G. ruber and G. sacculifer show, in general, lower concentrations and less seasonal variability in all sites. The lower variability is reflected in the model output, but the small scale variations are not reproduced by the model in several locations. Due to the fact that the model is forced by climatological data, it can not capture interannual variations. The sensitivity experiments we carried out show that, inside the temperature tolerance range, food availability is the main parameter which controls the abundance of some species. The here presented model represents a powerful tool to explore the response of planktonic foraminifera to different boundary conditions, and to quantify the seasonal bias in foraminifera-based proxy records

Human urine certified reference material CZ 6010: creatinine and toluene metabolites (hippuric acid and o-cresol) and a benzene metabolite (phenol)

A reference material for the biological monitoring of occupational exposure to toluene, benzene and phenol was prepared. O-cresol and hippuric acid (metabolites of toluene) are used for the biological monitoring of occupational exposure to toluene. Phenol, a metabolite of benzene, is used for the biological monitoring of exposure to benzene, but phenol can of course also be used as an indicator of exposure to phenol as well. The reference material (RM) used for the determination of these metabolites was prepared by freeze-drying pooled urine samples obtained from healthy persons occupationally exposed to toluene and those taking part in an inhalation experiment. Tests for homogeneity and stability were performed by determining urine concentrations of o-cresol, hippuric acid, creatinine and phenol. To investigate the stability of the RM, the urinary concentrations of o-cresol and phenol were monitored for eighteen months using GC and HPLC, while those of hippuric acid and creatinine were followed for five and six years, respectively, using HPLC. Analysis of variance showed that the concentrations did not change. The certified concentration values (and their uncertainties) of the substances in this reference material (phenol concentration c=6.46+/-0.58 mg l(-1); o-cresol concentration c=1.17+/-0.15 mg l(-1); hippuric acid concentration c=1328+/-30 mg l(-1); creatinine concentration c=0.82+/-0.10 g l(-1)) were evaluated via the interactive statistical programme IPECA

The effect of using a pre-dive checklist on the incidence of diving mishaps in recreational scuba diving: a cluster-randomized trial

BACKGROUND: Scuba diving mishaps, caused by equipment problems or human errors, increase the occurrence of injuries and fatalities while diving. Pre-dive checklists may mitigate mishaps. This study evaluated the effect of using a pre-dive checklist on the incidence of diving mishaps in recreational divers. METHODS: A multi-location cluster-randomized trial with parallel groups and allocation concealment was conducted between 1 June and 17 August 2012. The participants had to be at least 18 years of age, permitted to dive by the dive operator and planning to dive on the day of participation. They were recruited at the pier and dive boats at four locations. The intervention group received a pre-dive checklist and post-dive log. The control group received a post-dive log only. The outcomes, self-reported major and minor mishaps, were prompted by a post-dive questionnaire. Mishap rates per 100 dives were compared using Poisson regression with generalized estimating equations. Intent-to-treat, per-protocol and marginal structural model analyses were conducted. RESULTS: A total of 1043 divers (intervention = 617; control = 426) made 2041 dives, on 70 location-days (intervention = 40; control = 30) at four locations. Compared with the control group, the incidence of major mishaps decreased in the intervention group by 36%, minor mishaps by 26% and all mishaps by 32%. On average, there was one fewer mishap in every 25 intervention dives. CONCLUSIONS: In this trial, pre-dive checklist use prevented mishaps which could lead to injuries and fatalities. Pre-dive checklists can increase diving safety and their use should be promoted. Trial Registration: ClinicalTrials.gov ID NCT01960738

Statistical properties of the low-temperature conductance peak-heights for Corbino discs in the quantum Hall regime

A recent theory has provided a possible explanation for the ``non-universal scaling'' of the low-temperature conductance (and conductivity) peak-heights of two-dimensional electron systems in the integer and fractional quantum Hall regimes. This explanation is based on the hypothesis that samples which show this behavior contain density inhomogeneities. Theory then relates the non-universal conductance peak-heights to the ``number of alternating percolation clusters'' of a continuum percolation model defined on the spatially-varying local carrier density. We discuss the statistical properties of the number of alternating percolation clusters for Corbino disc samples characterized by random density fluctuations which have a correlation length small compared to the sample size. This allows a determination of the statistical properties of the low-temperature conductance peak-heights of such samples. We focus on a range of filling fraction at the center of the plateau transition for which the percolation model may be considered to be critical. We appeal to conformal invariance of critical percolation and argue that the properties of interest are directly related to the corresponding quantities calculated numerically for bond-percolation on a cylinder. Our results allow a lower bound to be placed on the non-universal conductance peak-heights, and we compare these results with recent experimental measurements.Comment: 7 pages, 4 postscript figures included. Revtex with epsf.tex and multicol.sty. The revised version contains some additional discussion of the theory and slightly improved numerical result

Association of Injury History and Incident Injury in Cadet Basic Military Training

To determine the association between injury history at enrollment and incident lower extremity (LE) injury during cadet basic training among first-year military cadets

Analyses of a novel SCN5A mutation (C1850S): conduction vs. repolarization disorder hypotheses in the Brugada syndrome

Aims Brugada syndrome (BrS) is characterized by arrhythmias leading to sudden cardiac death. BrS is caused, in part, by mutations in the SCN5A gene, which encodes the sodium channel alpha-subunit Nav1.5. Here, we aimed to characterize the biophysical properties and consequences of a novel BrS SCN5A mutation. Methods and results SCN5A was screened for mutations in a male patient with type-1 BrS pattern ECG. Wild-type (WT) and mutant Nav1.5 channels were expressed in HEK293 cells. Sodium currents (INa) were analysed using the whole-cell patch-clamp technique at 37°C. The electrophysiological effects of the mutation were simulated using the Luo-Rudy model, into which the transient outward current (Ito) was incorporated. A new mutation (C1850S) was identified in the Nav1.5 C-terminal domain. In HEK293 cells, mutant INa density was decreased by 62% at −20 mV. Inactivation of mutant INa was accelerated in a voltage-dependent manner and the steady-state inactivation curve was shifted by 11.6 mV towards negative potentials. No change was observed regarding activation characteristics. Altogether, these biophysical alterations decreased the availability of INa. In the simulations, the Ito density necessary to precipitate repolarization differed minimally between the two genotypes. In contrast, the mutation greatly affected conduction across a structural heterogeneity and precipitated conduction block. Conclusion Our data confirm that mutations of the C-terminal domain of Nav1.5 alter the inactivation of the channel and support the notion that conduction alterations may play a significant role in the pathogenesis of Br

Universal relation between longitudinal and transverse conductivities in quantum Hall effect

We show that any critical transition region between two adjacent Hall plateaus in either integer or fractional quantum Hall effect is characterized by a universal semi-circle relationship between the longitudinal and transverse conductivities, provided the sample is homogeneous and isotropic on a large scale. This conclusion is demonstrated both for the phase-coherent quantum transport as well as for the incoherent transport.Comment: REVTEX 3.0, 1 figure, 4 pages. SISSA-08179