Recent progress in silica aerogel Cherenkov radiator

In this paper, we present recent progress in the development of hydrophobic silica aerogel as a Cherenkov radiator. In addition to the conventional method, the recently developed pin-drying method for producing high-refractive-index aerogels with high transparency was studied in detail. Optical qualities and large tile handling for crack-free aerogels were investigated. Sufficient photons were detected from high-performance aerogels in a beam test.Comment: Proceedings of 2nd International Conference on Technology and Instrumentation in Particle Physics (TIPP 2011), to be published in Physics Procedia, 8 pages, 7 figure

Molecular Classification of Enteroviruses Not Identified by Neutralization Tests

We isolated six viruses from patients diagnosed with aseptic meningitis or hand, foot, and mouth disease. The cytopathic effect of these viruses on cultured cells was like that of enteroviruses. However, viral neutralization tests against standard antisera were negative. Phylogenetic analysis with the complete VP4 nucleotide sequences of these 6 viruses and 29 serotypes of enteroviruses classified 3 of the viruses as serotype echovirus type 18 (EV18) and 3 as serotype human enterovirus 71 (HEV71). These results were confirmed by remicroneutralization tests with HEV-monospecific antisera or an additional phylogenetic analysis with the complete VP4 nucleotide sequences. Phylogenetic analysis with complete VP4 genes is more useful than neutralization tests with enterovirus serotype-specific antisera in identifying enterovirus serotypes

Perubahan Tatakelola Taman Nasional: Studi Kasus di Taman Nasional Gunung Halimun Salak

Changes in national parks (NP) governance include 1) change in NP management policy which was originally precedence for protection and preservation, now includes real economy for the community, 2) implementation process of the change at field level. This paper discusses the governance change in Gunung Halimun Salak National Park (TNGHS) and its impacts on resource users. Change in governance could take place if the interactive process that occurred between the Head of the National Park, field officers and the community included: (1) Clear and simple policy guidance from the Head of NP on the policy implementation of the new governance be given to field officers, (2) develop relationship between field officers and local community through active interaction. Shift in the implementation technique of NP governance for protection and preservation from "restrictions and provision of sanctions" to "participatory conservation" to achieve the goal of NP resources utilization for the community. The analysis showed that change in NP governance was achieved through the approach of participatory conservation processes, learning and increasing confidence that comes naturally among the field officers and local communities and conservation practices by local communities

Effects of Birth Month on Talent Identification Participation and the Identification Process in Sports

Topics in Exercise Science and Kinesiology Volume 2: Issue 1, Article 7, 2021. The purpose of this study was to clarify the effect of the birth month on Talent Identification (TI) participation and the identification process in sports. The subjects were 4th grade elementary school children (mean age, 9±5.8 years) who participated in the Talent Identification Project. The method of identification was two-stage. In the first stage, the 30 m sprint, standing broad jump, and medicine ball front throw (1 kg) were performed, and 99 boys and 97 girls with high overall scores were selected to participate in the second stage. In the second stage, in addition to the results of the first stage, the T-test, 20 m shuttle run, standing triple jump, rebound jump (RJ-index), medicine ball back throw (1 kg), and repeated horizontal jump were performed. In the T-test, subjects run straight to a point 10 m ahead, then, ran 5 m to the right, 10 m to the left, 5 m to the right, and returned 10 m back to the start. A total of 15 boys and 15 girls with high overall scores were selected from the second stage. As in a previous study, the birth month was divided into yearly quarters (1, April to June; 2, July to September; 3, October to December; and 4, January to March). Point of application ＃1: There was a bias in participation rates and final members in the TI project for 4th graders by birth month for both boys and girls. Point of application ＃2: In the case of 4th grade boys of the TI project, the medicine ball front throw, as an index of whole body power, was influenced by the birth month. Point of application ＃3: It was speculated that boys born between January and March had a smaller morphology (height and weight), and were disadvantaged in measurement tests related to morphology, such as the medicine ball front throw

PERUBAHAN TATAKELOLA TAMAN NASIONAL: STUDI KASUS DI TAMAN NASIONAL GUNUNG HALIMUN SALAK

Changes in national parks (NP) governance include 1) change in NP management policy which was originally precedence for protection and preservation, now includes real economy for the community, 2) implementation process of the change at field level. This paper discusses the governance change in Gunung Halimun Salak National Park (TNGHS) and its impacts on resource users. Change in governance could take place if the interactive process that occurred between the Head of the National Park, field officers and the community included: (1) Clear and simple policy guidance from the Head of NP on the policy implementation of the new governance be given to field officers, (2) develop relationship between field officers and local community through active interaction. Shift in the implementation technique of NP governance for protection and preservation from "restrictions and provision of sanctions" to "participatory conservation" to achieve the goal of NP resources utilization for the community. The analysis showed that change in NP governance was achieved through the approach of participatory conservation processes, learning and increasing confidence that comes naturally among the field officers and local communities and conservation practices by local communities. Keywords: change in NP governance, restrictions and provisions of sanctions, participatory conservation, learning, increasing confidence

93Nb- and 27Al-NMR/NQR studies of the praseodymium based PrNb2Al20

International Conference on Strongly Correlated Electron Systems 2014 (SCES2014

Thermoluminescence characteristics and chemical compositions of mesostases in ordinary chondrites

Induced thermoluminescence (TL) images of ordinary chondrites, ALH-77214 (L3.4-3.5), Y-74191 (L3.6), ALH-77216 (L3.8) and ALH-78043 (L6), were measured by the TL spatial distribution readout system combined with a microscope and TL characteristics [peak temperature and peak width] of mesostases were analyzed. Their chemical compositions were also analyzed by an electron probe X-ray microanalyzer. We found that; (1) The mesostasis was responsible for much of the TL in the ordinary chondrites, (2) A mesostasis of normative anorthite compositions showed low peak temperature (∿90℃) and narrow width (∿65℃), while a mesostasis of normative albite compositions showed high peak temperature (∿125℃) and wide width (∿100℃), (3) A main phosphor in a low petrologic grade chondrite 3.5 was a high albite mesostasis, (4) Some chondrules in the same fragments of the type 3 chondrites showed no or weak TL emission and these mesostases had high normative albite. These facts suggest that in type 3 ordinary chondrites; (1) The post-accretional metamorphism cannot account for the coexistence of high albite mesostases with TL emission and no emission and a high anorthite mesostasis with TL emission, (2) Low petrologic grade chondrites 3.5 have a large population of slowly cooled chondrules

Development of the photomultiplier tube readout system for the first Large-Sized Telescope of the Cherenkov Telescope Array

The Cherenkov Telescope Array (CTA) is the next generation ground-based very high energy gamma-ray observatory. The Large-Sized Telescope (LST) of CTA targets 20 GeV -- 1 TeV gamma rays and has 1855 photomultiplier tubes (PMTs) installed in the focal plane camera. With the 23 m mirror dish, the night sky background (NSB) rate amounts to several hundreds MHz per pixel. In order to record clean images of gamma-ray showers with minimal NSB contamination, a fast sampling of the signal waveform is required so that the signal integration time can be as short as the Cherenkov light flash duration (a few ns). We have developed a readout board which samples waveforms of seven PMTs per board at a GHz rate. Since a GHz FADC has a high power consumption, leading to large heat dissipation, we adopted the analog memory ASIC "DRS4". The sampler has 1024 capacitors per channel and can sample the waveform at a GHz rate. Four channels of a chip are cascaded to obtain deeper sampling depth with 4096 capacitors. After a trigger is generated in a mezzanine on the board, the waveform stored in the capacitor array is subsequently digitized with a low speed (33 MHz) ADC and transferred via the FPGA-based Gigabit Ethernet to a data acquisition system. Both a low power consumption (2.64 W per channel) and high speed sampling with a bandwidth of $>$300 MHz have been achieved. In addition, in order to increase the dynamic range of the readout we adopted a two gain system achieving from 0.2 up to 2000 photoelectrons in total. We finalized the board design for the first LST and proceeded to mass production. Performance of produced boards are being checked with a series of quality control (QC) tests. We report the readout board specifications and QC results.Comment: In Proceedings of the 34th International Cosmic Ray Conference (ICRC2015), The Hague, The Netherlands. All CTA contributions at arXiv:1508.0589

A phase 2 basket trial of combination therapy with trastuzumab and pertuzumab in patients with solid cancers harboring human epidermal growth factor receptor 2 amplification (JUPITER trial)

Introduction: Human epidermal growth factor receptor 2 (HER2) gene amplification and mutations have emerged as oncogenic drivers and therapeutic targets not limited to breast and gastric cancers, but also in a variety of cancers. However, even if an actionable gene alteration is found, the incidence of HER2 amplification in these cancers is less than 5%. It is too difficult to conduct a conventional randomized, controlled trial in a rare fraction. Therefore, we have designed a organ-agnostic basket study, which covers a variety of solid cancers harboring HER2 amplification, in 1 study protocol. Methods/Design: This trial is a multicenter, single-arm, basket phase 2 study in Japan. Patients with solid cancers harboring HER2 amplification that have progressed with standard treatment, or rare cancers for which there is no standard treatment, will be eligible. Target cancers include bile duct, urothelial, uterine, ovarian, and other solid cancers where HER2 amplification is detected by comprehensive genomic profiling using next-generation sequencing technology. A total of 38 patients will be treated with combination therapy with trastuzumab and pertuzumab every 3 weeks until disease progression, unmanageable toxicity, death, or patient refusal. The primary endpoint is the objective response rate, and secondary endpoints are progression-free survival, overall survival, and duration of response. Discussion: The aim of this trial is to evaluate the safety and efficacy of combination therapy with trastuzumab and pertuzumab in patients with locally advanced or metastatic, solid cancers harboring HER2 amplification. Instead of focusing on 1 organ type, our trial design uses a basket study focusing on HER2 amplification, regardless of the site or origin of the cancer. The results of our study will advance clinical and scientific knowledge concerning the treatment of locally advanced, rare solid cancers harboring HER2 amplification, using the combination of trastuzumab and pertuzumab. Trial registration: This trial was registered in Japan Registry of Clinical Trials (jCRT) on February 25, 2019, as jRCT2031180150