Technikfiktionen und Technikdiskurse : Ringvorlesung des Instituts für Literaturwissenschaft im Sommersemester 2009

Die Beiträge der KIT-Ringvorlesung Technikfiktionen – Technikdiskurse aus dem Jahr 2009 reflektieren das gleichermaßen komplexe, komplizierte wie doch auch fruchtbare Verhältnis von Literatur, Kultur und Technik vornehmlich aus der Position und Perspektive der Geistes- und Sozialwissenschaften (bzw. Kulturwissenschaften). Sie behandeln aus literatur-, kultur- und medienwissenschaftlicher sowie technikhistorischer Perspektive Themen aus einem Zeitraum von gut achthundert Jahren

Glück - Zufall - Vorsehung : Vortragsreihe der Abteilung Mediävistik des Instituts für Literaturwissenschaft im Sommersemester 2008

Die Aufsätze befassen sich mit Vorstellungen von Glück, Zufall, Vorsehung primär an Beispielen primär der mittelalterlichen und neuzeitlichen Literatur, aber auch philosophischer, ethnologischer, kulturgeschichtlicher Quellen. Die grundlegende Frage, an denen sie sich orientieren, ist die nach den Wirkungen einer \u27Macht\u27 bzw. Instanzen, die - abseits identifizierbarer kausaler Kräfte - in persönliche, ebenso historisch-politische Prozesse einwirken oder das Handeln literarischer Figuren lenken

MicroRNAs as salivary markers for periodontal diseases

The aim of this review is to discuss current findings regarding the roles of miRNAs in periodontal diseases and the potential use of saliva as a diagnostic medium for corresponding miRNA investigations. For periodontal disease, investigations have been restricted to tissue samples and five miRNAs, that is, miR-142-3p, miR-146a, miR-155, miR-203, and miR-223, were repeatedly validated in vivo and in vitro by different validation methods. Particularly noticeable are the small sample sizes, different internal controls, and different case definitions of periodontitis in in vivo studies. Beside of that, the validated miRNAs are associated with inflammation and therefore with various diseases. Furthermore, several studies successfully explored the use of salivary miRNA species for the diagnosis of oral cancer. Different cancer types were investigated and heterogeneous methodology was used; moreover, no overlap of resultswas found. In conclusion, fivemiRNAs have consistently been reported for periodontitis; however, their disease specificity, detectability, and expression in saliva and their importance as noninvasive markers are questionable. In principle, a salivary miRNA diagnostic method seems feasible.However, standardized criteria and protocols for preanalytics, measurements, and analysis should be established to obtain comparable results across different studies

Evaluation of α(MZ2)\alpha(M_{\rm Z}^2) and (g−2)μ(g-2)_\mu

This talk summarizes the recent developments in the evaluation of the leading order hadronic contributions to the running of the QED fine structure constant $\alpha(s)$, at $s=M_{\rm Z}^2$, and to the anomalous magnetic moment of the muon $(g-2)_\mu$. The accuracy of the theoretical prediction of these observables is limited by the uncertainties on the hadronic contributions. Significant improvement has been achieved in a series of new analyses which is presented historically in three steps: (I), use of $\tau$ spectral functions in addition to $e^+e^-$ cross sections, (II), extended use of perturbative QCD and (III), application of QCD sum rule techniques. The most precise values obtained are: $\Delta\alpha_{\rm had}(M_{\rm Z}^2)$, $=(276.3\pm1.6)\times10^{-4}$, yielding $\alpha^{-1}(M_{\rm Z}^2)=128.933\pm0.021$, and $a_\mu^{\rm had}=(692.4\pm6.2)\times 10^{-10}$ with which one finds for the complete Standard Model prediction $a_\mu^{\rm SM}=(11 659 159.6\pm6.7)\times10^{-10}$. For the electron $(g-2)_e$, the hadronic contribution is $a_e^{\rm had}=(187.5\pm1.8)\times 10^{-14}$.Comment: 13 page

Radiative corrections to e+e−→H+H−e^+ e^- \to H^+ H^-: THDM versus MSSM

One loop radiative corrections to $e^+e^-\to H^+ H^-$ are considered at future linear collider energies, in the general type II Two Higgs Doublet Model (THDM) and in the Minimal Supersymmetric Standard Model-like (MSSM) Higgs sector. To make the comparison between THDM and MSSM tractable, we have introduced a quasi-SUSY parameterization which preserves all the tree-level Higgs mass-sum-rules of the MSSM, and involves just 3 free parameters in the Higgs sector (instead of 7 in the general THDM) and comprises the MSSM as a particular case. The model-independent soft photon contribution is isolated and shown to be substantial. Important effects come also from the contribution of the model dependent $h^0 H^+ H^-$ and $H^0 H^+ H^-$ vertices to the final state. In the MSSM, the contribution of the Higgs sector is moderate (a few percent) while in the THDM and both for small and large $\tan \beta$ important effects ($\sim +30$) can be found.Comment: 46 pages, LaTeX, 9 figures, shortened and revised version, to be published in Nuclear Physics

Dezentrale Energieversorgung: Dezentrale Energieversorgung für die Landwirtschaft und den ländlichen Raum

Die Energiewende ist in aller Munde. Doch zu einfach ist der Gedanke es gehe nur um Wind, Photovoltaik und Biogas. Im Landwirtschaftsbetrieb müssen alle Energieerzeuger und –verbraucher intelligent miteinander gekoppelt und verwoben werden. Bestenfalls kann Energie – in welcher Form auch immer – an den ländlichen Raum abgegeben werden. Die vorliegende Schriftenreihe stellt reale Betriebseispiele für die Landwirtschaft vor. Interessierte Landwirte können hier Anregungen zur fossilfreien energetischen Umgestaltung ihres Betriebes finden. Redaktionsschluss: 30.09.202

The influence of electron multiplication and internal X-ray fluorescence on the performance of a scintillator-based gamma camera

When considering the "standard" gamma-camera, one might picture an array of photo-multiplier tubes or a similar array of small-area detectors. This array of imaging detectors would be attached to a corresponding array of scintillator modules (or a solid layer of scintillator) in order to give a high detection efficiency in the energy region of interest, usually 8-140 keV. Over recent years, developments of gamma-cameras capable of achieving much higher spatial resolutions have led to a new range of systems based on Charge-Coupled Devices with some form of signal multiplication between the scintillator and the CCD in order for one to distinguish the light output from the scintillator above the CCD noise. The use of an Electron-Multiplying Charge-Coupled Device (EM-CCD) incorporates the gain process within the CCD through a form of "impact ionisation", however, the gain process introduces an "excess noise factor" due to the probabilistic nature of impact ionisation and this additional noise consequently has an impact on the spatial and spectral resolution of the detector. Internal fluorescence in the scintillator, producing K-shell X-ray fluorescence photons that can be detected alongside the incident gamma-rays, also has a major impact on the imaging capabilities of gamma-cameras. This impact varies dramatically from the low spatial resolution to high spatial resolution camera system. Through a process of simulation and experimental testing focussed on the high spatial resolution (EM-CCD based) variant, the factors affecting the performance of gamma-camera systems are discussed and the results lead to important conclusions to be considered for the development of future systems. This paper presents a study into the influence of the EM-CCD gain process and the internal X-ray fluorescence in the scintillator on the performance of scintillator-based gamma cameras (CCD-based or otherwise), making use of Monte Carlo simulations to demonstrate the aspects involved, their influence on the imaging system and the hypotheses previously discussed in experimental studies

Das komplexe Beckentrauma: Matching des Beckenregisters DGU mit dem TraumaRegister DGU®

BACKGROUND Complex pelvic traumas, i.e., pelvic fractures accompanied by pelvic soft tissue injuries, still have an unacceptably high mortality rate of about 18 %. PATIENTS AND METHODS We retrospectively evaluated an intersection set of data from the TraumaRegister DGU® and the German Pelvic Injury Register from 2004-2009. Patients with complex and noncomplex pelvic traumas were compared regarding their vital parameters, emergency management, stay in the ICU, and outcome. RESULTS From a total of 344 patients with pelvic injuries, 21 % of patients had a complex and 79 % a noncomplex trauma. Complex traumas were significantly less likely to survive (16.7 % vs. 5.9 %). Whereas vital parameters and emergency treatment in the preclinical setting did not differ substantially, patients with complex traumas were more often in shock and showed acute traumatic coagulopathy on hospital arrival, which resulted in more fluid volumes and transfusions when compared to patients with noncomplex traumas. Furthermore, patients with complex traumas had more complications and longer ICU stays. CONCLUSION Prevention of exsanguination and complications like multiple organ dysfunction syndrome still pose a major challenge in the management of complex pelvic traumas

Guinea pig models for translation of the developmental origins of health and disease hypothesis into the clinic

Over 30 years ago Professor David Barker first proposed the theory that events in early life could explain an individual\u27s risk of non-communicable disease in later life: the developmental origins of health and disease (DOHaD) hypothesis. During the 1990s the validity of the DOHaD hypothesis was extensively tested in a number of human populations and the mechanisms underpinning it characterised in a range of experimental animal models. Over the past decade, researchers have sought to use this mechanistic understanding of DOHaD to develop therapeutic interventions during pregnancy and early life to improve adult health. A variety of animal models have been used to develop and evaluate interventions, each with strengths and limitations. It is becoming apparent that effective translational research requires that the animal paradigm selected mirrors the tempo of human fetal growth and development as closely as possible so that the effect of a perinatal insult and/or therapeutic intervention can be fully assessed. The guinea pig is one such animal model that over the past two decades has demonstrated itself to be a very useful platform for these important reproductive studies. This review highlights similarities in the in utero development between humans and guinea pigs, the strengths and limitations of the guinea pig as an experimental model of DOHaD and the guinea pig\u27s potential to enhance clinical therapeutic innovation to improve human health. (Figure presented.)

Intravenous antibiotics for pulmonary exacerbations in people with cystic fibrosis

BACKGROUND: Cystic fibrosis is a multi-system disease characterised by the production of thick secretions causing recurrent pulmonary infection, often with unusual bacteria. Intravenous antibiotics are commonly used in the treatment of acute deteriorations in symptoms (pulmonary exacerbations); however, recently the assumption that exacerbations are due to increases in bacterial burden has been questioned. OBJECTIVES: To establish if intravenous antibiotics for the treatment of pulmonary exacerbations in people with cystic fibrosis improve short- and long-term clinical outcomes. SEARCH METHODS: We searched the Cochrane Cystic Fibrosis Trials Register, compiled from electronic database searches and handsearching of journals and conference abstract books. We also searched the reference lists of relevant articles and reviews and ongoing trials registers.Date of last search of Cochrane trials register: 27 July 2015. SELECTION CRITERIA: Randomised controlled trials and the first treatment cycle of cross-over studies comparing intravenous antibiotics (given alone or in an antibiotic combination) with placebo, inhaled or oral antibiotics for people with cystic fibrosis experiencing a pulmonary exacerbation. DATA COLLECTION AND ANALYSIS: The authors assessed studies for eligibility and risk of bias and extracted data. MAIN RESULTS: We included 40 studies involving 1717 participants. The quality of the included studies was largely poor and, with a few exceptions, these comprised of mainly small, inadequately reported studies.When comparing treatment with a single antibiotic to a combined antibiotic regimen, those participants receiving a combination of antibiotics experienced a greater improvement in lung function when considered as a whole group across a number of different measurements of lung function, but with very low quality evidence. When limited to the four placebo-controlled studies (n = 214), no difference was observed, again with very low quality evidence. With regard to the review's remaining primary outcomes, there was no effect upon time to next exacerbation and no studies in any comparison reported on quality of life. There were no effects on the secondary outcomes weight or adverse effects. When comparing specific antibiotic combinations there were no significant differences between groups on any measure. In the comparisons between intravenous and nebulised antibiotic or oral antibiotic (low quality evidence), there were no significant differences between groups on any measure. No studies in any comparison reported on quality of life. AUTHORS' CONCLUSIONS: The quality of evidence comparing intravenous antibiotics with placebo is poor. No specific antibiotic combination can be considered to be superior to any other, and neither is there evidence showing that the intravenous route is superior to the inhaled or oral routes. There remains a need to understand host-bacteria interactions and in particular to understand why many people fail to fully respond to treatment