Direction and Production of Shakespeare\u27s Comedy Much Ado About Nothing

This project includes the selection, background research and documentation, direction, production, and post-production analysis of Sammamish High School\u27s production of William Shakespeare\u27s Much Ado About Nothing. Documentation includes research, analysis of the play, and an evaluation of the comedy as a production for Sammamish High School

Why social mobility is key to explaining attitudes toward multiculturalism

What explains attitudes toward multiculturalism in Europe? And how do citizens without a migration background react when the cities they live in become more diverse? Drawing on a new study, Lisa-Marie Kraus and Stijn Daenekindt show that social mobility is a key factor in determining why some people are more optimistic about multiculturalism than others

3D models of the hematopoietic stem cell niche under steady-state and active conditions

Hematopoietic stem cells (HSCs) in the bone marrow are able to differentiate into all types of blood cells and supply the organism each day with billions of fresh cells. They are applied to cure hematological diseases such as leukemia. The clinical need for HSCs is high and there is a demand for being able to control and multiply HSCs in vitro. The hematopoietic system is highly proliferative and thus sensitive to anti-proliferative drugs such as chemotherapeutics. For many of these drugs suppression of the hematopoietic system is the dose-limiting toxicity. Therefore, biomimetic 3D models of the HSC niche that allow to control HSC behavior in vitro and to test drugs in a human setting are relevant for the clinics and pharmacology. Here, we describe a perfused 3D bone marrow analog that allows mimicking the HSC niche under steady-state and activated conditions that favor either HSC maintenance or differentiation, respectively, and allows for drug testing