Long-term results of a nationwide general ultrasound screening system for developmental disorders of the hip: the Austrian hip screening program

Background The Financial Standard Accounting Board (FASB) is concerned the deterioration of utility of the financial information. For this reason, FASB opened a process of consultations and deliberations with object of including it in its calendar: it was obvious the importance of the investments on innovation, but the generally accepted accounting principles in USA (US GAAP) didn’t allow their recognition like asset. So, our question is, with independence of accounting treatment for R&D, do the investors consider them important? Aims This paper aims to examine the value-relevance of R&D expenditures, using a regression model based on the Ohlson equity-valuation framework. We contribute evidence about the direction that the international standards should follow. Instrument and Sample The instrument consists in different specifications of a valuation model, in other words, of Ohlson Model (1995). The sample is composed by U.S listed firms automotive over a 10-year period (1995-2004). Results and Conclusions Our findings show the association between current and the lagged R&D expenditure and stock price is negative and significant. These findings indicate that the investors consider that current R&D is an expense and is not an asset.Antecedentes El Financial Accounting Standard Board preocupado ante el deterioro de la utilidad de la información financiera, abrió un proceso de consultas y deliberaciones con objeto de incluir esta preocupación en su agenda: quedaba patente la importancia de las inversiones conductoras de la innovación, pero los principios de contabilidad generalmente aceptados en el ámbito estadounidense (conocidos por las siglas US GAAP) no permitían su reconocimiento como activos. La cuestión que nos planteamos es: ¿Con independencia del tratamiento contable asignado a las partidas de I+D, los inversores las consideran relevantes? Objetivo En el presente trabajo de investigación trataremos de contrastar la relevancia del valor de los gastos de I+D corriente y con retardo de un ejercicio económico. Metodología y muestra Usando como función base el modelo de Ohlson (1995), introducimos variantes del mismo y con ellas, fijamos nuestro objetivo en la modelización del precio de cotización. La muestra está formada por empresas que cotizan en Estados Unidos y que pertenecen al sector del automóvil. El horizonte temporal analizado comprende 10 años. Resultado y conclusiones Nuestros resultados muestran que los inversores consideran que los gastos de I+D corriente y los del ejercicio anterior no aportan valor añadido a las compañías, es decir, que los valoran como cualquier otro gasto del ejercicio y que, por tanto, no son relevantes para estimar el valor de mercado de las compañías que forman nuestra muestra

Long-term adherence to pessary use in women with pelvic organ prolapse: A retrospective cohort study

Purpose of the research: Vaginal pessary use is an established, non-surgical treatment option for pelvic organ prolapse. While satisfaction rates are initially high, they seem to decline over time. We aimed to determine the median duration of pessary use among our patients and to evaluate reasons for discontinuation. Methods: All patients who were treated with a vaginal pessary for pelvic organ prolapse between 2007 and 2022 at our institution (a maximum observation period of 15 years) were included in this retrospective cohort study. Data were collected from the in-house electronic databases and the date of pelvic floor surgery was defined as the primary endpoint. In case of no documented surgery, the date of the last follow-up visit (for patients lost to follow-up or who discontinued pessary use without subsequent surgery) or the date of final data collection (for those with presumed continued pessary use) was used as the primary endpoint. Duration of pessary use is represented by Kaplan-Meier curves. Effects of possible confounders were investigated by Cox regression models. A Cox regression model was evaluated for patients with the three most common types of pessary: ring, cube and shell. A chi-square test was performed to compare therapy adherence according to pessary type. Principal results: Data of 779 patients could be included in the statistical analysis. The estimated median duration of pessary use was 173 weeks (95 % CI 104-473) - approximately 3.3 years. Overall, 30 % of patients opted for surgical therapy and the majority of them did so within 4 months of initiation of pessary use (median time: 19 weeks, 95 % CI 16-26). In 5 % of cases a discontinuation of pessary use without subsequent surgery was documented and 18 % were lost to follow-up before a planned visit, thus leaving 47 % of our patients with presumed continued pessary use. Possible confounding factors for discontinuation of pessary use were tested but were found to be non-significant (body mass index, Pelvic Organ Prolapse - Quantification score, pelvic floor training, age, parity, menopausal status, nicotine consumption, incontinence or size of pessary). Reasons for discontinuation of pessary use were documented in 51 % of patients: unspecified patient wish (23 %), pessary use tiredness (10 %), general dissatisfaction with pessary therapy (7 %), unspecified reasons (5 %), pessary self-change not possible (1 %), erosion, bleeding, pain (2 %); none of the pessary types fitted (2 %). Conclusions: According to our data, almost half of our patients with pelvic organ prolapse and pessary therapy continued pessary use until a maximum follow-up time of 15 years, whereas about one-third of patients finally opted for surgical repair (a majority of these within 4 months after pessary therapy initiation). The remaining patients were either lost to follow-up or discontinued pessary use without subsequent surgery. The stated reasons for discontinuation of pessary use were mostly non-specific, but only 1 % reported that pessary self-change was not possible. Erosion bleeding or pain was documented in only 2 % of cases as reason for discontinuation. This information helps clinicians to inform their patients with pelvic organ prolapse about expected pessary therapy success and strengthens individual counselling. Furthermore, our data indicates vaginal pessary use for pelvic organ prolapse is feasible and safe for all women and that therapy adherence can extend beyond 5 years

Duration of invasive mechanical ventilation prior to extracorporeal membrane oxygenation is not associated with survival in acute respiratory distress syndrome caused by coronavirus disease 2019

BACKGROUND: Duration of invasive mechanical ventilation (IMV) prior to extracorporeal membrane oxygenation (ECMO) affects outcome in acute respiratory distress syndrome (ARDS). In coronavirus disease 2019 (COVID-19) related ARDS, the role of pre-ECMO IMV duration is unclear. This single-centre, retrospective study included critically ill adults treated with ECMO due to severe COVID-19-related ARDS between 01/2020 and 05/2021. The primary objective was to determine whether duration of IMV prior to ECMO cannulation influenced ICU mortality. RESULTS: During the study period, 101 patients (mean age 56 [SD ± 10] years; 70 [69%] men; median RESP score 2 [IQR 1–4]) were treated with ECMO for COVID-19. Sixty patients (59%) survived to ICU discharge. Median ICU length of stay was 31 [IQR 20.7–51] days, median ECMO duration was 16.4 [IQR 8.7–27.7] days, and median time from intubation to ECMO start was 7.7 [IQR 3.6–12.5] days. Fifty-three (52%) patients had a pre-ECMO IMV duration of > 7 days. Pre-ECMO IMV duration had no effect on survival (p = 0.95). No significant difference in survival was found when patients with a pre-ECMO IMV duration of < 7 days (< 10 days) were compared to ≥ 7 days (≥ 10 days) (p = 0.59 and p = 1.0). CONCLUSIONS: The role of prolonged pre-ECMO IMV duration as a contraindication for ECMO in patients with COVID-19-related ARDS should be scrutinised. Evaluation for ECMO should be assessed on an individual and patient-centred basis. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13613-022-00980-3

The Intraocular Cytokine Profile and Therapeutic Response in Persistent Neovascular Age-Related Macular Degeneration

Citation: Rezar-Dreindl S, Sacu S, Eibenberger K, et al. The intraocular cytokine profile and therapeutic response in persistent neovascular agerelated macular degeneration. Invest Ophthalmol Vis Sci. 2016;57:4144-4150. DOI:10.1167/iovs.16-19772 PURPOSE. To investigate the course of inflammatory and angiogenic cytokines in the aqueous humor of patients with persistent/recurrent neovascular age-related macular degeneration (nAMD) under ranibizumab monotherapy (IVM) or ranibizumab plus dexamethasone combination treatment. METHODS. In this 12-month prospective study, 40 eyes with nAMD were treated with either IVM or combined treatment with ranibizumab plus intravitreal dexamethasone implant (IVC). Patients in the IVM group were treated following an &apos;&apos;as needed&apos;&apos; treatment regimen; patients in the IVC group received ranibizumab and a dexamethasone implant at baseline and were retreated with ranibizumab. At baseline and at each time of retreatment aqueous humor samples were taken. RESULTS. Before treatment, levels of macrophage chemoattractant protein (MCP)-1, monokine induced by c interferon (MIG), and lipocalin-2/ neutrophil gelatinase-associated lipocalin (NGAL) were elevated in nAMD patients compared to healthy controls (P ¼ 0.024; P ¼ 0.04; P ¼ 0.01). In contrast, tumor necrosis factor a, IL-12p70, and secreted protein acidic and rich in cysteine (SPARC) concentrations were lower (P ¼ 0.001; P ¼ 0.008; P ¼ 0.03), while vascular endothelial growth factor (VEGF) was not altered (45 6 6/51 6 12 pg/mL nAMD/ control group; P ¼ 0.6). During IVC, levels of VEGF, MIG, platelet-derived growth factor (PDGF)-AA, and transforming growth factor b1 (P ¼ 0.005; P ¼ 0.011; P ¼ 0.008; P ¼ 0.013) were reduced. Ranibizumab monotherapy did not influence the course of any inflammatory/ angiogenic cytokine. Interleukin 6 and PDGF-AA levels correlated with central retinal thickness changes (P ¼ 0.007; P ¼ 0.022). Over the 12-month period visual function was maintained with no significant differences during or between both treatment groups. CONCLUSIONS. Inflammatory proteins are involved in the pathogenesis of chronic macular edema due to AMD and are associated with disease activity. During combined treatment, levels of inflammatory and angiogenic cytokines decreased over a 12-month period with no superiority in functional outcome

Inverse Bandstructure Engineering of Alternative Barrier Materials for InGaAs-based Terahertz Quantum Cascade Lasers

The final publication is available via https://doi.org/10.1109/CLEOE-EQEC.2017.8086449.Quantum cascade lasers (QCLs) are compact and powerful sources that cover a wide spectral range from infrared to terahertz (THz) radiation. The emission characteristics of QCLs depend on design parameters such as layer thickness, material composition and doping. Therefore, the material system has to be chosen accurately. This paper implemented an inverse quantum engineering algorithm to investigate the influence of the barrier material on the lasing performance and characteristics of THz active regions. Starting from an original design, barrier materials are exchanged while the wave functions are kept constant. A systematic comparison between material systems such as InGaAs/InAlAs, InGaAs/GaAsSb and InGaAs/InAlGaAs was performed with focus on quantum transport and optical gain. The quantum design with the wave functions, the electrical and the optical properties of two InGaAs-based devices, one of which is employs ternary InAlAs barriers, whereas the other device employs quaternary InAlGaAs barriers is presented. As designed, the algorithm leads to almost identical wave functions for different barrier thickness due to the different CBOs of the investigated materials. Results find that thin barrier devices employing ternary barrier materials such as InAlAs show the highest optical gain. Consequently the InGaAs/InAlAs material system, which is already commonly used for mid-infrared quantum cascade lasers, is also very well suited for high performance THz QCLs

Anamnestic risk factor questionnaire as reliable diagnostic instrument for osteoporosis (reduced bone morphogenic density)

<p>Abstract</p> <p>Background</p> <p>Osteoporosis is a major health problem worldwide, and is included in the WHO list of the top 10 major diseases. However, it is often undiagnosed until the first fracture occurs, due to inadequate patient education and lack of insurance coverage for screening tests. Anamnestic risk factors like positive family anamnesis or early menopause are assumed to correlate with reduced BMD.</p> <p>Methods</p> <p>In our study of 78 patients with metaphyseal long bone fractures, we searched for a correlation between anamnestic risk factors, bone specific laboratory values, and the bone morphogenic density (BMD). Each indicator was examined as a possible diagnostic instrument for osteoporosis. The secondary aim of this study was to demonstrate the high prevalence of osteoporosis in patients with metaphyseal fractures.</p> <p>Results</p> <p>76.9% of our fracture patients had decreased bone density and 43.6% showed manifest osteoporosis in DXA (densitometry) measurements. Our questionnaire, identifying anamnestic risk factors, correlated highly significantly (p = 0.01) with reduced BMD, whereas seven bone-specific laboratory values (p = 0.046) correlated significantly.</p> <p>Conclusions</p> <p>Anamnestic risk factors correlate with pathological BMD. The medical questionnaire used in this study would therefore function as a cost-effective primary diagnostic instrument for identification of osteoporosis patients.</p

Time-Interleaved Digital-to-Analog Converters for UWB Signal Generation

Abstract-In this paper, a differentially encoded Time

Investigation of noise transmission of a machine tool enclosure

Machine tools are highly integrated mechatronic systems consisting of dedicated mechanic design and integrated electrical equipment – in particular drive systems and the CNC-control – to realize the complex relative motion of tool towards work piece. Beside the process related capabilities, like static and dynamic stiffness as well as accuracy behavior and deviation resistance against thermal influence, safety aspects are of major interest. The machine tool enclosure must fulfill multiple requirements like retention capabilities against the moving parts of broken tools, lose work pieces or clamping components. In regular use, the noise emission have to be inhibited at the greatest possible extent by the machine tool enclosure. Nevertheless, the loading door and the moving parts of the workspace envelope are interfaces where noise transmission is harder to be avoided and therefore local noise emissions increase. The aim of the objective investigation is to analyse the noise emission of machine tools to determine the local noise transmission of a machine tool enclosure by using arrays of microphones. By the use of this measuring method, outer surfaces at the front, the side and on the top of the enclosure have been scanned. The local transient acoustic pressures have been recorded using a standard noise source placed on the machine table. In addition, an exemplary manufacturing process has been performed to analyse the frequency dependent location resolved sound emissions