424 research outputs found
PRIVILEGE AND INVISIBILITY IN THE NEW WORK ORDER: A REPLY TO KYNG
Abstract not available
ΠΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ ΠΈΠ½ΡΡΡΡΠΌΠ΅Π½ΡΠΎΠ² ΠΎΠΏΡΠΈΠΌΠΈΠ·Π°ΡΠΈΠΈ Π΄Π»Ρ ΠΏΠΎΠ²ΡΡΠ΅Π½ΠΈΡ ΠΊΠΎΠ½Π²Π΅ΡΡΠΈΠΎΠ½Π½ΠΎΡΡΠΈ ΡΠ°ΠΉΡΠ° ΠΊΠΎΠΌΠΏΠ°Π½ΠΈΠΈ
ΠΠ±ΡΠ΅ΠΊΡΠΎΠΌ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΡΠ²Π»ΡΠ΅ΡΡΡ ΡΠΈΡΡΠ΅ΠΌΠ° ΠΎΠΏΡΠΈΠΌΠΈΠ·Π°ΡΠΈΠΈ ΡΠ°ΠΉΡΠ° ΠΊΠΎΠΌΠΌΠ΅ΡΡΠ΅ΡΠΊΠΎΠΉ ΠΊΠΎΠΌΠΏΠ°Π½ΠΈΠΈ Π² ΠΈΠ·ΠΌΠ΅Π½ΡΡΡΠΈΡ
ΡΡ ΡΡΠ»ΠΎΠ²ΠΈΡΡ
.
ΠΡΠ΅Π΄ΠΌΠ΅ΡΠΎΠΌ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΡΠ²Π»ΡΠ΅ΡΡΡ ΠΏΡΠΎΡΠ΅ΡΡ ΡΠ°Π·ΡΠ°Π±ΠΎΡΠΊΠΈ ΠΈ ΡΠ΅Π°Π»ΠΈΠ·Π°ΡΠΈΠΈ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠ° ΠΈΠ½ΡΡΡΡΠΌΠ΅Π½ΡΠΎΠ² SEO-ΠΎΠΏΡΠΈΠΌΠΈΠ·Π°ΡΠΈΠΈ ΡΠ°ΠΉΡΠ° ΠΊΠΎΠΌΠΏΠ°Π½ΠΈΠΈ Π΄Π»Ρ ΠΏΠΎΠ²ΡΡΠ΅Π½ΠΈΡ Π΅Π³ΠΎ ΠΊΠΎΠ½Π²Π΅ΡΡΠΈΠΎΠ½Π½ΠΎΡΡΠΈ.
Π¦Π΅Π»ΡΡ ΡΠ°Π±ΠΎΡΡ ΡΠ²Π»ΡΠ΅ΡΡΡ ΡΠ°Π·ΡΠ°Π±ΠΎΡΠΊΠ° Π°Π»Π³ΠΎΡΠΈΡΠΌΠ° ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠ° ΠΈΠ½ΡΡΡΡΠΌΠ΅Π½ΡΠΎΠ² SEO-ΠΎΠΏΡΠΈΠΌΠΈΠ·Π°ΡΠΈΠΈ ΡΠ°ΠΉΡΠ° ΠΊΠΎΠΌΠΏΠ°Π½ΠΈΠΈ ΠΈ Π΅Π³ΠΎ Π²Π½Π΅Π΄ΡΠ΅Π½ΠΈΠ΅ Π΄Π»Ρ ΠΏΠΎΠ²ΡΡΠ΅Π½ΠΈΡ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»Π΅ΠΉ ΠΊΠΎΠ½Π²Π΅ΡΡΠΈΠΈ.
ΠΠ°ΡΡΠ½Π°Ρ Π·Π½Π°ΡΠΈΠΌΠΎΡΡΡ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΡΠΎΡΡΠΎΠΈΡ Π² ΡΠ°Π·ΡΠ°Π±ΠΎΡΠΊΠ΅ Π°Π»Π³ΠΎΡΠΈΡΠΌΠ° ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠ° ΠΈΠ½ΡΡΡΡΠΌΠ΅Π½ΡΠΎΠ² SEO-ΠΎΠΏΡΠΈΠΌΠΈΠ·Π°ΡΠΈΠΈ ΡΠ°ΠΉΡΠ° ΠΊΠΎΠΌΠΌΠ΅ΡΡΠ΅ΡΠΊΠΎΠΉ ΠΊΠΎΠΌΠΏΠ°Π½ΠΈΠΈ Ρ ΡΠ΅Π»ΡΡ ΠΏΠΎΠ²ΡΡΠ΅Π½ΠΈΡ Π΅Π³ΠΎ ΠΊΠΎΠ½Π²Π΅ΡΡΠΈΠΎΠ½Π½ΠΎΡΡΠΈ.
ΠΡΠ°ΠΊΡΠΈΡΠ΅ΡΠΊΠ°Ρ Π·Π½Π°ΡΠΈΠΌΠΎΡΡΡ Π·Π°ΠΊΠ»ΡΡΠ°Π΅ΡΡΡ Π² ΡΡΠΏΠ΅ΡΠ½ΠΎΠΉ Π°ΠΏΡΠΎΠ±Π°ΡΠΈΠΈ ΡΠ°Π·ΡΠ°Π±ΠΎΡΠ°Π½Π½ΠΎΠ³ΠΎ Π°Π»Π³ΠΎΡΠΈΡΠΌΠ° ΠΈ Π²Π½Π΅Π΄ΡΠ΅Π½ΠΈΠΈ ΠΏΡΠ΅Π΄Π»ΠΎΠΆΠ΅Π½Π½ΡΡ
ΡΠ΅ΠΊΠΎΠΌΠ΅Π½Π΄Π°ΡΠΈΠΉ Π² ΠΈΡΡΠ»Π΅Π΄ΡΠ΅ΠΌΠΎΠΉ ΠΊΠΎΠΌΠΏΠ°Π½ΠΈΠΈ.The object of the research is a system for optimizing the site of a commercial company in changing conditions.
The subject of the research is the development process and a set of tools for SEO-optimization of a company's website to increase its conversion.
The aim of the work is to develop an algorithm for using a set of tools for SEO-optimization of the company's website and its implementation to increase conversion rates.
The scientific significance of the research includes an algorithm for using a set of SEO tools for optimizing a company's website in order to increase its conversion rate.
The practical significance lies in the successful testing of the developed algorithm and the implementation of the proposed recommendations in the company under study
Recommended from our members
The information procurement and publishing behaviour of researchers in the natural sciences and engineering : Evaluation of a survey focusing on non-textual material
[no abstract available
Centerscope
Centerscope, formerly Scope, was published by the Boston University Medical Center "to communicate the concern of the Medical Center for the development and maintenance of improved health care in contemporary society.
Recommended from our members
Informationsbeschaffungs- und Publikationsverhalten von Wissenschaftlerinnen und Wissenschaftlern der natur- und ingenieurwissenschaftlichen FΓ€chern : Auswertung einer Umfrage mit Schwerpunkt auf nicht-textuellen Materialien
[no abstract available
Recommended from our members
Circulating vitamin D concentrations and risk of breast and prostate cancer: a Mendelian randomization study.
BACKGROUND: Observational studies have suggested an association between circulating vitamin D concentrations [25(OH)D] and risk of breast and prostate cancer, which was not supported by a recent Mendelian randomization (MR) analysis comprising 15β748 breast and 22β898 prostate-cancer cases. Demonstrating causality has proven challenging and one common limitation of MR studies is insufficient power. METHODS: We aimed to determine whether circulating concentrations of vitamin D are causally associated with the risk of breast and prostate cancer, by using summary-level data from the largest ever genome-wide association studies conducted on vitamin D (Nβ=β73β699), breast cancer (Ncaseβ=β122β977) and prostate cancer (Ncaseβ=β79β148). We constructed a stronger instrument using six common genetic variants (compared with the previous four variants) and applied several two-sample MR methods. RESULTS: We found no evidence to support a causal association between 25(OH)D and risk of breast cancer [OR per 25βnmol/L increase, 1.02 (95% confidence interval: 0.97-1.08), Pβ=β0.47], oestrogen receptor (ER)+ [1.00 (0.94-1.07), Pβ=β0.99] or ER- [1.02 (0.90-1.16), Pβ=β0.75] subsets, prostate cancer [1.00 (0.93-1.07), Pβ=β0.99] or the advanced subtype [1.02 (0.90-1.16), Pβ=β0.72] using the inverse-variance-weighted method. Sensitivity analyses did not reveal any sign of directional pleiotropy. CONCLUSIONS: Despite its almost five-fold augmented sample size and substantially improved statistical power, our MR analysis does not support a causal effect of circulating 25(OH)D concentrations on breast- or prostate-cancer risk. However, we can still not exclude a modest or non-linear effect of vitamin D. Future studies may be designed to understand the effect of vitamin D in subpopulations with a profound deficiency
Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use.
Tobacco and alcohol use are leading causes of mortality that influence risk for many complex diseases and disorders1. They are heritable2,3 and etiologically related4,5 behaviors that have been resistant to gene discovery efforts6-11. In sample sizes up to 1.2βmillion individuals, we discovered 566 genetic variants in 406 loci associated with multiple stages of tobacco use (initiation, cessation, and heaviness) as well as alcohol use, with 150 loci evidencing pleiotropic association. Smoking phenotypes were positively genetically correlated with many health conditions, whereas alcohol use was negatively correlated with these conditions, such that increased genetic risk for alcohol use is associated with lower disease risk. We report evidence for the involvement of many systems in tobacco and alcohol use, including genes involved in nicotinic, dopaminergic, and glutamatergic neurotransmission. The results provide a solid starting point to evaluate the effects of these loci in model organisms and more precise substance use measures
Circulating vitamin D concentration and risk of seven cancers: Mendelian randomisation study
Objective To determine if circulating concentrations of vitamin D are causally associated with risk of cancer.Design Mendelian randomisation study.Setting Large genetic epidemiology networks (the Genetic Associations and Mechanisms in Oncology (GAME-ON), the Genetic and Epidemiology of Colorectal Cancer Consortium (GECCO), and the Prostate Cancer Association Group to Investigate Cancer Associated Alterations in the Genome (PRACTICAL) consortiums, and the MR-Base platform).Participants 70β563 cases of cancer (22β898 prostate cancer, 15β748 breast cancer, 12β537 lung cancer, 11β488 colorectal cancer, 4369 ovarian cancer, 1896 pancreatic cancer, and 1627 neuroblastoma) and 84β418 controls.Exposures Four single nucleotide polymorphisms (rs2282679, rs10741657, rs12785878 and rs6013897) associated with vitamin D were used to define a multi-polymorphism score for circulating 25-hydroxyvitamin D (25(OH)D) concentrations.Main outcomes measures The primary outcomes were the risk of incident colorectal, breast, prostate, ovarian, lung, and pancreatic cancer and neuroblastoma, which was evaluated with an inverse variance weighted average of the associations with specific polymorphisms and a likelihood based approach. Secondary outcomes based on cancer subtypes by sex, anatomic location, stage, and histology were also examined.Results There was little evidence that the multi-polymorphism score of 25(OH)D was associated with risk of any of the seven cancers or their subtypes. Specifically, the odds ratios per 25 nmol/L increase in genetically determined 25(OH)D concentrations were 0.92 (95% confidence interval 0.76 to 1.10) for colorectal cancer, 1.05 (0.89 to 1.24) for breast cancer, 0.89 (0.77 to 1.02) for prostate cancer, and 1.03 (0.87 to 1.23) for lung cancer. The results were consistent with the two different analytical approaches, and the study was powered to detect relative effect sizes of moderate magnitude (for example, 1.20-1.50 per 25 nmol/L decrease in 25(OH)D for most primary cancer outcomes. The Mendelian randomisation assumptions did not seem to be violated.Conclusions There is little evidence for a linear causal association between circulating vitamin D concentration and risk of various types of cancer, though the existence of causal clinically relevant effects of low magnitude cannot be ruled out. These results, in combination with previous literature, provide evidence that population-wide screening for vitamin D deficiency and subsequent widespread vitamin D supplementation should not currently be recommended as a strategy for primary cancer prevention
A yeast MAPK cascade regulates pexophagy but not other autophagy pathways
The S. cerevisiae Slt2p MAPK cascade picks out peroxisomes for autophagy-mediated degradation (pexophagy) but is not involved in turnover of other cellular components
- β¦