The Impact of Campus Culture on Undergraduate Civic Engagement Outcomes

One purpose of higher education is to prepare students to participate in a democratic society. This mission is particularly relevant today as the institutions of democracy and the ideas that underpin them are in recession. Despite this, evidence shows that higher education is not achieving its stated goal of fostering civic engagement. The creation and maintenance of an institutional culture can be an effective way to teach civic engagement. The Carnegie Community Engagement Classification (CEC) signifies that a college or university has institutionalized community engagement. By comparing student civic engagement outcomes at institutions that earned the classification to a control group of institutions that never applied, and to institutions that applied unsuccessfully, it is possible to determine whether student outcomes vary due to a culture of community engagement. This study used a quasi-experimental non-equivalent control group design to test whether a culture of community engagement impacts student civic engagement outcomes. Study participants were 27,423 undergraduates at 127 colleges and universities in the United States. Participants completed two surveys created by the Higher Education Research Institute: The Freshman Survey (TFS) and the College Senior Survey (CSS). Data from four cohorts of students—those who graduated in 2016, 2017, 2018, and 2019—were analyzed. Paired sample t test shows civic engagement increased slightly during college. Multiple regression analysis showed identity characteristics and experiences during college predicted a student’s civic engagement. There is generally no difference in civic engagement by race at TFS, but at CSS many students of color have lower civic engagement than white students. Joining a fraternity or sorority and studying abroad predicted a higher civic engagement score and a higher likelihood to vote. Being a varsity athlete predicted a lower civic engagement score and a lower likelihood of voting. An increase in social agency predicted the highest increase in civic engagement. Difference-in-differences analysis (DiD) generally showed no significant difference between the change in civic engagement outcomes based on CEC classification status. However, stratified results show that culture impacts students differently based on their civic engagement upon entering college and suggests that campus culture normalizes an average level of civic engagement

Characterization of cellular viability drop during media and platform development

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Metabolic engineering of high-productivity CHO host lines for biomanufacturing

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Systems Engineering Lessons Learned from Solar Array Structures and Mechanisms Deployment

This report has been developed by the National Aeronautics and Space Administration (NASA) Human Exploration and Operations Mission Directorate (HEOMD) Risk Management team in close coordination with the Engineering Directorate at LaRC. This document provides a point-in-time, cumulative, summary of actionable key lessons learned derived from the design project. Lessons learned invariably address challenges and risks and the way in which these areas have been addressed. Accordingly the risk management thread is woven throughout the document

Dynamic regulation of mitochondrial metabolism as a strategy to maximize mAb production in industrial CHO cell cultures

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A 73-Year-Old Female With Palpitations

Background Atrial fibrillation is a commonly encountered clinical problem. Although a large percentage of patients have no dearly identifiable precipitant, secondary atrial fibrillation is a well-documented clinical entity.\u27 Case presentation A 73-year-old female with a history of obstructive sleep apnea, hypertension, and chronic obstructive pulmonary disease presents with complaints of intermittent palpitations, substernal squeezing chest pressure, and shortness ofbreath for two weeks. Her most recent episode occurred on the bus, prompting her to come to the emergency room for evaluation. Further questioning revealed mild weight loss and diarrhea over the prior few weeks. Home medications included amlodipine, baby aspirin, albuterol as needed, and ciprofloxacin for a recently diagnosed URI

Identifying the metabolomic fingerprint of high and low flavonoid consumers

High flavonoid consumption can improve vascular health. Exploring flavonoid–metabolome relationships in population-based settings is challenging, as: (i) there are numerous confounders of the flavonoid–metabolome relationship; and (ii) the set of dependent metabolite variables are inter-related, highly variable and multidimensional. The Metabolite Fingerprint Score has been developed as a means of approaching such data. This study aims to compare its performance with that of more traditional methods, in identifying the metabolomic fingerprint of high and low flavonoid consumers. This study did not aim to identify biomarkers of intake, but rather to explore how systemic metabolism differs in high and low flavonoid consumers. Using liquid chromatography–tandem MS, 174 circulating plasma metabolites were profiled in 584 men and women who had complete flavonoid intake assessment. Participants were randomised to one of two datasets: (a) training dataset, to determine the models for the discrimination variables (n 399); and (b) validation dataset, to test the capacity of the variables to differentiate higher from lower total flavonoid consumers (n 185). The stepwise and full canonical variables did not discriminate in the validation dataset. The Metabolite Fingerprint Score successfully identified a unique pattern of metabolites that discriminated high from low flavonoid consumers in the validation dataset in a multivariate-adjusted setting, and provides insight into the relationship of flavonoids with systemic lipid metabolism. Given increasing use of metabolomics data in dietary association studies, and the difficulty in validating findings using untargeted metabolomics, this paper is of timely importance to the field of nutrition. However, further validation studies are required

Nasal mucosal melanosis may act as a harbinger of melanoma: A case report

Background: The progression from a benign pigmented lesion on the skin to cutaneous melanoma is better understood, and it could be presumed that a similar progression occurs with mucosal lesions. However, to our knowledge, there has never been documentation of melanosis transforming into melanoma over time. Objective: To describe a transformation of a mucosal melanosis into melanoma. Methods: A 53-year-old man with diffuse melanosis of the nasal cavity underwent surgical resection. Results: Pathology revealed melanocytic hyperplasia without evidence of melanoma. The patient was serially examined, with excisions for new areas of melanosis. The pathology progressed to severely atypical melanocytic proliferation and melanoma in situ over a 4-year period. Conclusion: Nasal melanosis may be a precancerous lesion and may transform into melanoma. All melanosis should be biopsied with close endoscopic observation. Lesions with dysplasia or atypia should be excised due to potential transformation to melanoma

Definition von Flexibilität in einem zellulär geprägten Energiesystem

Bereits existierende nationale und internationale Definitionen des Begriffs Flexibilität sind zu unpräzise und werden den Anforderungen, die sich bei der Beschreibung von Flexibilität innerhalb eines zellulären Energiesystems ergeben, nicht gerecht. Diese Arbeit benennt und definiert Flexibilitätsbegriffe, um ein gemeinsames Verständnis zu schaffen. Zunächst werden die technisch-ökonomischen Flexibilitätsbegriffe Fahrkurve, Flexibilitäts-bereitstellung, Flexibilitätserbringung, Quantifizierbarkeit, Prognostizierbarkeit sowie explizite und implizite Flexibilität beschrieben. Im Anschluss werden Begriffe beschrieben, die mit der Ansteuerung und dem Abruf von Flexibilität einhergehen. Darunter fallen die aktive und passive Flexibilitätserbringung, der zustands- und kommunikationsgesteuerte Flexibilitätsabruf sowie der direkte und indirekte Flexibilitätsabruf. Zuletzt wird eine Unterscheidung anhand des Verwendungszwecks in system-, netz- und marktdienliche Flexibilität vorgenommen. Das Ergebnis sind exakte Begriffsdefinitionen und Begriffsabgrenzungen, auf deren Basis Flexibilitätsprodukte beschrieben und kategorisiert werden können, die für die Konzeption und Demonstration eines zellulären geprägten Energiesystems unabdingbar sind

SLC2A8 (GLUT8) is a mammalian trehalose transporter required for trehalose-induced autophagy

Trehalose is a disaccharide demonstrated to mitigate disease burden in multiple murine neurodegenerative models. We recently revealed that trehalose rapidly induces hepatic autophagy and abrogates hepatic steatosis by inhibiting hexose transport via the SLC2A family of facilitative transporters. Prior studies, however, postulate that intracellular trehalose is sufficient to induce cellular autophagy. The objective of the current study was to identify the means by which trehalose accesses the hepatocyte cytoplasm, and define the distal signaling mechanisms by which trehalose induces autophagy. We provide gas chromatographic/mass spectrometric, fluorescence microscopic and radiolabeled uptake evidence that trehalose traverses the plasma membrane via SLC2A8 (GLUT8), a homolog of the trehalose transporter-1 (Tret1). Moreover, GLUT8-deficient hepatocytes and GLUT8-deficient mice exposed to trehalose resisted trehalose-induced AMP-activated protein kinase (AMPK) phosphorylation and autophagic induction in vitro and in vivo. Although trehalose profoundly attenuated mTORC1 signaling, trehalose-induced mTORC1 suppression was insufficient to activate autophagy in the absence of AMPK or GLUT8. Strikingly, transient, heterologous Tret1 overexpression reconstituted autophagic flux and AMPK signaling defects in GLUT8-deficient hepatocyte cultures. Together, these data suggest that cytoplasmic trehalose access is carrier-mediated, and that GLUT8 is a mammalian trehalose transporter required for hepatocyte trehalose-induced autophagy and signal transduction