One and Two Way Packaging in the Dairy Sector

Choosing packaging material for dairy products and soft drinks is an interesting issue at the moment. Discussions arise on the costs impacts and environmental impacts of both one way packaging and reusable packaging. The aim of this article is to develop an evaluation tool providing costs and environmental impacts of the PC-bottle and the GT-packs in the dairy sector, considering forward and return flows. The evaluation tool enables the user to analyse the costs and environmental impacts of a supply chain with and without return flows using scenario analyses with respect to the use of various carrier types and the number of return loops. It appears that costs differences between PC-bottles and GT-pack are quite small. The PC bottle has a better environmental profile than the GT-pack. Scenario analysis on the carriers results in the advice to use preferably roll-in-containers with direct delivery, secondly roll-in-containers with delivery via distribution centers, thirdly in case of direct delivery either cartons or crates and cartons in case of delivery via distribution centers

Role of macrophage sialoadhesin in host defense against the sialylated pathogen group B <em>Streptococcus</em>

ABSTRACT: Several bacterial pathogens decorate their surfaces with sialic acid (Sia) residues within cell wall components or capsular exopolysaccharides. Sialic acid expression can promote bacterial virulence by blocking complement activation or by engagement of inhibitory sialic acid-binding immunoglobulin-like lectins (Siglecs) on host leukocytes. Expressed at high levels on splenic and lymph node macrophages, sialoadhesin (Sn) is a unique Siglec with an elongated structure that lacks intracellular signaling motifs. Sialoadhesin allows macrophage to engage certain sialylated pathogens and stimulate inflammatory responses, but the in vivo significance of sialoadhesin in infection has not been shown. We demonstrate that macrophages phagocytose the sialylated pathogen group B Streptococcus (GBS) and increase bactericidal activity via sialoadhesin-sialic-acid-mediated recognition. Sialoadhesin expression on marginal zone metallophillic macrophages in the spleen trapped circulating GBS and restricted the spread of the GBS to distant organs, reducing mortality. Specific IgM antibody responses to GBS challenge were also impaired in sialoadhesin-deficient mice. Thus, sialoadhesin represents a key bridge to orchestrate innate and adaptive immune defenses against invasive sialylated bacterial pathogens. KEY MESSAGE: Sialoadhesin is critical for macrophages to phagocytose and clear GBS. Increased GBS organ dissemination in the sialoadhesin-deficient mice. Reduced anti-GBS IgM production in the sialoadhesin-deficient mice. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s00109-014-1157-y) contains supplementary material, which is available to authorized users