Small business in Russia: everyday issues and development constraints

The article is based on the data of “Russian longitudinal monitoring survey of economic situation and public health NRU HSE” (RLMS-HSE) and considers current issues and specifics of social well-being of entrepreneurs engaged in small business – managers of micro-enterprises and individual entrepreneurs as one of the least protected professional groups who face great difficulties in organizing their business. The analysis confirms that numerous lingering problems impeding their work cause a reduction in the level of entrepreneurial activity, significantly worsen the social well-being of entrepreneurs and force many of them to change professional and life plans. The study reveals that social well-being of entrepreneurs engaged in small business is complex and uncertain; it is a consequence of an inconsistency between conditions of life and work, and the heterogeneity of this category of employees. They feel happy more often than wage workers. However, possessing a relatively high level of job satisfaction and life satisfaction in general, and having higher self-assessment of professional skills, small-scale entrepreneurs are less concerned with the low prestige of their work and their lack of wide power and authority in comparison to other categories of employed persons; they are cautious in establishing relationships with other people and they have a comparatively low level of law-abidance. The article proves that one of the conditions for successful functioning and development of small business consists in a balanced combination of entrepreneurial activity, initiative and efficient state governance. However, today, entrepreneurial ability, which should be the main driving force of the new Russian economy, is used extremely inefficiently, which is evident from the abnormally low level of entrepreneurial activity of citizens. And only about half of those who want to start their own business or establish their own company succeed. Only a small part of them clearly expresses the desire to gain new knowledge and master new technology and other work sphere

<i>RBM20</i>-Associated Ventricular Arrhythmias in a Patient with Structurally Normal Heart

RBM20 (RNA-binding motif protein 20) is a splicing factor targeting multiple cardiac genes, and its mutations cause cardiomyopathies. Originally, RBM20 mutations were discovered to cause the development of dilated cardiomyopathy by erroneous splicing of the gene TTN (titin). Titin is a giant protein found in a structure of the sarcomere that functions as a molecular spring and provides a passive stiffness to the cardiomyocyte. Later, RBM20 mutations were also described in association with arrhythmogenic right ventricular cardiomyopathy and left ventricular noncompaction cardiomyopathy. Here, we present a clinical case of a rare arrhythmogenic phenotype and no structural cardiac abnormalities associated with a RBM20 genetic variant of uncertain significance

RBM20-Associated Ventricular Arrhythmias in a Patient with Structurally Normal Heart

RBM20 (RNA-binding motif protein 20) is a splicing factor targeting multiple cardiac genes, and its mutations cause cardiomyopathies. Originally, RBM20 mutations were discovered to cause the development of dilated cardiomyopathy by erroneous splicing of the gene TTN (titin). Titin is a giant protein found in a structure of the sarcomere that functions as a molecular spring and provides a passive stiffness to the cardiomyocyte. Later, RBM20 mutations were also described in association with arrhythmogenic right ventricular cardiomyopathy and left ventricular noncompaction cardiomyopathy. Here, we present a clinical case of a rare arrhythmogenic phenotype and no structural cardiac abnormalities associated with a RBM20 genetic variant of uncertain significance