A novel IgE antibody targeting the prostate-specific antigen as a potential prostate cancer therapy

Prostate cancer (PCa) is the second leading cause of cancer deaths in men in the United States. The prostate-specific antigen (PSA), often found at high levels in the serum of PCa patients, has been used as a marker for PCa detection and as a target of immunotherapy. The murine IgG1 monoclonal antibody AR47.47, specific for human PSA, has been shown to enhance antigen presentation by human dendritic cells and induce both CD4 andCD8 T-cell activation when complexed with PSA. In this study, we explored the properties of a novel mouse/human chimeric anti-PSA IgE containing the variable regions of AR47.47 as a potential therapy for PCa. Our goal was to take advantage of the unique properties of IgE in order to trigger immune activation against PCa.Fil: Daniels-Wells, Tracy R. University of California. David Geffen School of Medicine. Department of Surgery. Division of Surgical Oncology; Estados Unidos de América;Fil: Helguera, Gustavo Fernando. Universidad de Buenos Aires. Facultad de Farmacia y Bioquimica. Departamento de Tecnologia Farmaceutica; Argentina; University of California. David Geffen School of Medicine. Department of Surgery. Division of Surgical Oncology; Estados Unidos de América;Fil: Leuchter, Richard K. University of California. David Geffen School of Medicine. Department of Surgery. Division of Surgical Oncology; Estados Unidos de América;Fil: Quintero, Rafael. University of California. David Geffen School of Medicine. Department of Surgery. Division of Surgical Oncology; Estados Unidos de América;Fil: Kozman, Maggie. University of California. David Geffen School of Medicine. Department of Surgery. Division of Surgical Oncology; Estados Unidos de América;Fil: Rodríguez, José A.. University of California. David Geffen School of Medicine. Department of Surgery. Division of Surgical Oncology; Estados Unidos de América; University of California. The Molecular Biology Institute; Estados Unidos de América;Fil: Ortiz-Sánchez, E. University of California. David Geffen School of Medicine. Department of Surgery. Division of Surgical Oncology; Estados Unidos de América; Biomedical Research in Cancer. Basic Research Division. National Institute of Cancerology; Mexico.;Fil: Martínez-Maza, Otonel. University of California. David Geffen School of Medicine. Department of Surgery. Division of Surgical Oncology; Estados Unidos de América;Fil: Schultes, Brigit C.. Advanced Immune Therapeutics; Estados Unidos de América;Fil: Nicodemus Christopher. Advanced Immune Therapeutics; Estados Unidos de América;Fil: Penichet, Manuel. University of California. David Geffen School of Medicine. Department of Surgery. Division of Surgical Oncology; Estados Unidos de América; University of California. The Molecular Biology Institute; Estados Unidos de América

Spurring or Blurring Professional Standards? The Role of Digital Technology in Implementing Journalistic Role Ideals in Contemporary Newsrooms

This study examines the perceived relevance and implementation of competing normative ideals in journalism in times of increasing use of digital technology in newsrooms. Based on survey and content analysis data from 37 countries, we found a small positive relationship between the use of digital research tools and “watchdog” performance. However, a stronger and negative relationship emerged between the use of digital audience analytics and the performance of “watchdog” and “civic” roles, leading to an overall increase in conception–performance gaps on both roles. Moreover, journalists’ use of digital community tools was more strongly and positively associated with “infotainment” and “interventionism.”

Comparing Journalistic Role Performance Across Thematic Beats: A 37-Country Study

Studies suggest that, at the routine level, news beats function as unique “micro-cultures.” Exploring this “particularist” approach in news content, we compare how the interventionist, watchdog, loyal, service, infotainment, and civic roles materialize across 11 thematic news beats and analyze the moderating effect of platforms, ownership, and levels of political freedom on journalistic role performance in hard and soft news. Based on the second wave of the Journalistic Role Performance (JRP) project, this article reports the findings of a content analysis of 148,474 news items from 37 countries. Our results reveal the transversality of interventionism, the strong associations of some topics and roles, and the limited reach of news beat particularism in the face of moderating variables

A Management Tool for Analyzing CHP Natural Gas Liquids Recovery System

The objective of this research is to develop a management tool for analyzing combined heat and power (CHP) natural gas liquids (NGL) recovery systems. The methodology is developed around the central ideas of product recovery, possible recovery levels, and the flexibility of the process. These ideas led to the design of the CHP-NGL recovery system and the development of the equipment sizing and economic analysis methods. Requirements for sizing refrigeration units, heat exchangers, and pumps are discussed and demonstrated. From the data sheets it is possible to gather costs associated with the project and demonstrate the economic feasibility of the system. The amount of NGL recovered, heating value, payback period, cash flow, net present value of money, and the internal rate of return are calculated and demonstrated to be favorable to this project

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A Preliminary Study on Designing Combined Heat and Power (CHP) System for the University Environment

Combined heat and power (CHP) systems are an evolving technology that is at the front of the energy conservation movement. With the reduction in energy consumption and green house gas emissions, CHP systems are improving the efficiency of power generation. Our goal for this research is to develop a specification for a CHP System that will improve the University of Louisiana at Lafayette’s operating efficiency. This system will reduce the operating cost of the university and provide reliable, clean energy to the College of Engineering and surrounding buildings. If this system is implemented correctly, it has the ability to meet the economic and reliability needs of the university. CHP systems are the combination of various forms of equipment to meet the electrical and thermal needs from one single fuel source. Major steps involved in the development of a CHP system including data collection and analysis, system calculations and system specifications will be discussed. This research also examines the barriers that CHP systems encounter with environmental regulations and grid interconnection

The Results (Lessons Learned) of More than 110 Energy Audits for Manufacturers by the Louisiana Industrial Assessment Center

This paper and discussion presents the summary and results of energy audits or assessments conducted by the University of Louisiana Lafayette Industrial Assessment Center, which is sponsored by the US Department of Energy, for the first four years of operation. To insure the confidentiality of our clients, the results are generalized and summarized by industry type and recommendation type. Where the assessment finding and recommendations have been implemented, the implementation rate is shown. For recommendations that have the most significant savings and a high implementation rate, we will show the summarized implementation cost and payback period. The Industrial Assessment Center of the University of Louisiana Lafayette began operation in FY01 and conducted its first industrial energy assessment in December 2000. In this paper we present the results of this energy assessment and those of 112 more through August 2004. By industrial type, these assessments were for: Oilfield Equipment Manufacturing (23%), Food and Food Processing (18%), Petrochemical Manufacturing and Refineries (13%), Other (non-Oilfield) Equipment Manufacturing (12%), Ship Building and Repair (8%), Woodworking, Clothing and Wire Manufacturing (6%), Paper, Cardboard, Boxes and Bag Manufacturing (5%), Machining (4%), Building and Building Materials (4%), Printing (4%), and Glass and Ceramics Manufacturing (3%). The distribution of manufacturers for the State of Louisiana is weighted much higher in the Petrochemical Manufacturing and Refineries, however because of limitations on the amount of energy consumed (restrictions for the Industrial Assessment Centers), many of these are beyond the scope for Industrial Assessment Centers. For most of the recommendations we make, we try to keep the installation cost (parts and labor) within a one-year payback period. However, we have occasionally looked at longer payback periods when suggested by the client. The recommendations for each industry type are summarized in the following ten categories: air leaks and operating compressed air pressure (includes methods to lower cost by lowering the operating air pressure), replace air tools with electric tools (includes grinders, chippers, wrenches, and fans or blowers to replace air horns), installation of insulation (on hot or cold equipment, pipes and buildings), lighting (photo sensors, reductions, occupancy sensors, and LED exit signs), recycling, combustion efficiency and CHP, steam leaks and traps, heating and cooling (people and space), alternative fuels and operations, and productivity improvements (including preventive maintenance and group lighting replacement)