71 research outputs found
Diagnosis and Prognostication of Ductal Adenocarcinomas of the Pancreas Based on Genome-Wide DNA Methylation Profiling by Bacterial Artificial Chromosome Array-Based Methylated CpG Island Amplification
To establish diagnostic criteria for ductal adenocarcinomas of the pancreas (PCs), bacterial artificial chromosome (BAC) array-based methylated CpG island amplification was performed using 139 tissue samples. Twelve BAC clones, for which DNA methylation status was able to discriminate cancerous tissue (T) from noncancerous pancreatic tissue in the learning cohort with a specificity of 100%, were identified. Using criteria that combined the 12 BAC clones, T-samples were diagnosed as cancers with 100% sensitivity and specificity in both the learning and validation cohorts. DNA methylation status on 11 of the BAC clones, which was able to discriminate patients showing early relapse from those with no relapse in the learning cohort with 100% specificity, was correlated with the recurrence-free and overall survival rates in the validation cohort and was an independent prognostic factor by multivariate analysis. Genome-wide DNA methylation profiling may provide optimal diagnostic markers and prognostic indicators for patients with PCs
Identification of Adipophilin as a Potential Plasma Biomarker for Colorectal Cancer Using Label-Free Quantitative Mass Spectrometry and Protein Microarray
Surgery Including Liver Resection for Metastatic Gastrointestinal Stromal Tumors or Gastrointestinal Leiomyosarcomas
Tu1615 Prognostic Value of Additional Pancreatic Resection for Cancer Positive Cut Margins During Pancreaticoduodenectomy for Pancreatic Head Cancer
Mo1692 Extended Hepatectomy With Portal and Hepatic Artery Resection for Advanced Perihilar Cholangiocarcinoma
Su1774 Evaluation of Completion Rate of ‘Upfront Surgery and Adjuvant Chemotherapy’ According to Resectable Status of Pancreatic Head Cancers
Mo1661 Does the Pancreatic Resection Have Any Survival Benefit in Patients With a Pancreatic Adenocarcinoma and Intraoperatively Diagnosed Positive Para-Aortic Lymph Node Metastasis or Peritoneal Lavage Cytology?
Su1545 Reconsideration of Safety and Efficacy of Pancreaticoduodenectomy for Periampullary Cancers in Elderly Patients Aged ≥ 80 Years
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Increased DNA methyltransferase 1 (DNNT1) protein expression in precancerous conditions and ductal carcinomas of the pancreas
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