51 research outputs found
Исследование in silico взаимодействия производных 2’-{[(e)-андрост-5-ен-17-илиден]-метил}оксазолинов с андрогеновым рецептором
The ability of novel oxazolinyl derivatives of pregna-5,17(20)-diene to interact with the androgen receptor (AR) was investigated using molecular modelling methods. Six new derivatives differed in oxazolinyl radicals in 17 position were used. It was shown that all compounds were able to docked in the ligand-binding domain of AR only when the AR helix-12 was removed. It is suggested that these compounds have antagonistic properties. Results of docking and simulation of molecular dynamics with estimation of binding energy allow to predict that two compounds can be effective AR antagonists.Методами молекулярного моделирования оценена способность новых азотсодержащих стероидных производных 2’-{[(E)-андрост-5-ен-17-илиден]-метил}оксазолинов взаимодействовать с андрогенным рецептором. Исследованы 6 оксазолиновых производных 17(20)Е-прегна-5,17(20)-диена, различающихся структурой гетероцикла. Показано, что все соединения способны связываться с андрогенным рецептором только в случае, когда из структуры рецептора была удалена 12 спираль. Это позволяет предполагать, что данные лиганды должны проявлять антагонистические свойства. Результаты докинга и молекулярной динамики с оценкой энергии связывания лигандов позволили предположить, что два из исследованных соединений могут быть эффективными антагонистами андрогенного рецептора
Search for Exotic Mesons in pi- P Interactions at 18 GeV/c
The recent search for non mesons in interactions at
Brookhaven National Laboratory is summarized. Many final states such as , , , , , ,
which are favored decay modes of exotics, are under investigation.Comment: 9 pages, PostScript, Presented at the International School of Nuclear
Physics, Erice, Sicily, Italy, September 199
Confirmation of a pi_1^0 Exotic Meson in the \eta \pi^0 System
The exclusive reaction , at 18 GeV has been studied with a partial wave analysis on a sample
of 23~492 events from BNL experiment E852. A mass-dependent fit
is consistent with a resonant hypothesis for the wave, thus providing
evidence for a neutral exotic meson with , a mass of MeV, and a width of MeV. New
interpretations of the meson exotics in neutral system observed in
E852 and Crystal Barrel experiments are discussed.Comment: p3, rewording the paragraph (at the bottom) about the phase
variations. p4, rewording paragrath "The second method ..." . p4, at the
bottom of paragrath "The third method ..." added consistent with the results
of methods 1 and 2
Exotic Meson Production in the System observed in the Reaction at 18 GeV/c
This letter reports results from the partial wave analysis of the
final state in collisions at 18GeV/c.
Strong evidence is observed for production of two mesons with exotic quantum
numbers of spin, parity and charge conjugation, in the decay
channel . The mass MeV/c^2 and
width MeV/c^2 of the first state are consistent
with the parameters of the previously observed . The second
resonance with mass MeV/c^2 and width MeV/c^2 agrees very well with predictions from theoretical
models. In addition, the presence of is confirmed with mass MeV/c^2 and width MeV/c^2
and a new state, , is observed with mass
MeV/c^2 and width MeV/c^2. The decay properties of
these last two states are consistent with flux tube model predictions for
hybrid mesons with non-exotic quantum numbers
Observation of a New J(PC)=1(+-) Isoscalar State in the Reaction Pi- Proton -> Omega Eta Neutron at 18 GeV/c
Results are presented on a partial wave analysis of the Omega Eta final state
produced in Pi- Proton interactions at 18 GeVc where Omega -> Pi+ Pi- Pi0, Pi0
-> 2 Gammas, and Eta -> 2 Gammas. We observe the previously unreported decay
mode Omega(1650) -> Omega Eta and a new 1(+-) meson state h1(1595) with a mass
M=1594(15)(+10)(-60) MeV/c^2 and a width Gamma=384(60)(+70)(-100) MeV/c^2. The
h1(1595) state exhibits resonant-like phase motion relative to the Omega(1650).Comment: Submitted to Physics Letters B Eight total pages including 11 figures
and 1 tabl
Observation of Pseudoscalar and Axial Vector Resonances in pi- p -> K+ K- pi0 n at 18 GeV
A new measurement of the reaction pi- p -> K+ K- pi0 n has been made at a
beam energy of 18 GeV. A partial wave analysis of the K+ K- pi0 system shows
evidence for three pseudoscalar resonances, eta(1295), eta(1416), and
eta(1485), as well as two axial vectors, f1(1285), and f1(1420). Their observed
masses, widths and decay properties are reported. No signal was observed for
C(1480), an IG J{PC} = 1+ 1{--} state previously reported in phi pi0 decay.Comment: 7 pages, 6 figs, to be submitted to Phys. Let
A study of the reaction pim p --> omega pim p at 18 GeV/c: The D and S decay amplitudes for b1(1235) --> omega pi
The reaction pim p --> omega pim p, omega --> pip pim pi0 has been studied at
18 GeV/c. The omega pim mass spectrum is found to be dominated by the b1(1235).
Partial Wave Analysis shows that b1 production is dominated by natural parity
exchange. The S-wave and D-wave amplitudes for b1(1235) --> omega pi have been
determined, and it is found that the amplitude ratio, |D/S| = 0.269 +/-
(0.009)stat +/- (0.01)sys and the phase difference, phi(D-S) = 10.54 deg +/-
(2.4)stat +/- (3.9)sys.Comment: 7 pages, 9 figures, revtex4 format, to be published in Physics
Letters
Sensitivity Algorithm as a Solution of an Inverse Strength Problem Applied to Thin-Walled Structures
Interplay effects of carrier-envelope phase and plasmon resonances in terahertz generation by ionizing ultrashort optical pulses
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