17 research outputs found
Actin acting at the Golgi
The organization, assembly and remodeling of the actin cytoskeleton provide force and tracks for a variety of (endo)membrane-associated events such as membrane trafficking. This review illustrates in different cellular models how actin and many of its numerous binding and regulatory proteins (actin and co-workers) participate in the structural organization of the Golgi apparatus and in traf- ficking-associated processes such as sorting, biogenesis and motion of Golgi-derived transport carriers
RhoGDIα-dependent balance between RhoA and RhoC is a key regulator of cancer cell tumorigenesis
The intracellular levels and activity of RhoA and RhoC, two closely related homologues of the RhoGTPase family, are interdependent, and their cross-talk requires RhoGDIά. This dynamic balance regulates the activation of the ROCK downstream effector and the expression of several genes, including NAG-1, that alter tumorigenesis in vitro and in vivo