50 research outputs found
Sustainable Syntheses of Substituted Heterocycles through Ruthenium- and Palladium-Catalyzed Direct C−H Bond Functionalizations
Cationic Ruthenium Catalysts for Alkyne Annulations with Oximes by C–H/N–O Functionalizations
Cationic ruthenium(II) complexes enabled efficient redox-neutral
annulations of alkynes with readily available oximes. The catalytic
dehydrative C–H/N–O bond functionalization proved to
be broadly applicable and was shown to proceed through a reversible
cyclometalation
Cp*Co-III Catalyzed Site-Selective C-H Activation of Unsymmetrical O-Acyl Oximes: Synthesis of Multisubstituted Isoquinolines from Terminal and Internal Alkynes
The synthesis of isoquinolines by site-selective CH activation of O-acyl oximes with a Cp*Co-III catalyst is described. In the presence of this catalyst, the CH activation of various unsymmetrically substituted O-acyl oximes selectively occurred at the sterically less hindered site, and reactions with terminal as well as internal alkynes afforded the corresponding products in up to 98% yield. Whereas the reactions catalyzed by the Cp*Co-III system proceeded with high site selectivity (15:1 to 20:1), use of the corresponding Cp*Rh-III catalysts led to low selectivities and/or yields when unsymmetrical O-acyl oximes and terminal alkynes were used. Deuterium labeling studies indicate a clear difference in the site selectivity of the CH activation step under Cp*Co-III and Cp*Rh-III catalysis