A novel long non-coding natural antisense RNA is a negative regulator of Nos1 gene expression

Long non-coding natural antisense transcripts (NATs) are widespread in eukaryotic species. Although recent studies indicate that long NATs are engaged in the regulation of gene expression, the precise functional roles of the vast majority of them are unknown. Here we report that a long NAT (Mm-antiNos1 RNA) complementary to mRNA encoding the neuronal isoform of nitric oxide synthase (Nos1) is expressed in the mouse brain and is transcribed from the non-template strand of the Nos1 locus. Nos1 produces nitric oxide (NO), a major signaling molecule in the CNS implicated in many important functions including neuronal differentiation and memory formation. We show that the newly discovered NAT negatively regulates Nos1 gene expression. Moreover, our quantitative studies of the temporal expression profiles of Mm-antiNos1 RNA in the mouse brain during embryonic development and postnatal life indicate that it may be involved in the regulation of NO-dependent neurogenesis

Collective microwave scattering diagnostic on the H-1 heliac

A multichannel microwavescatteringdiagnostic has been developed and installed on the H-1 heliac. The purpose of the new diagnostic is to study small-scale plasma fluctuations in H-1, which are believed to be responsible for the loss of particles and energy from the plasma. The diagnostic is a 132 GHz, four-channel superheterodyne system. The transmitter and receiver antennas (consisting of horns and focusing bispherical mirrors) are located inside the vacuum vessel of H-1. A radial resolution of Δr/a∼0.2 is achieved. The scattering volume is positioned in the density gradient region at r/a∼0.6. At present, the system is aligned to measure fluctuations in the poloidal wave number range from approximately 10 to 25 cm⁻¹. The use of the heterodyne detection system allows the fluctuation propagation direction to be determined. The low frequency bandwidth of the system is 1 MHz. The instrument sensitivity is about Ps/Pi∼10⁻⁶

The MES-conception in the field of intrafirm training of workers

In article the modular approach to the organization and realization intrafirm training of workers is considered. The essence of modular training and the basic directions of the analysis of concept «module» is determined. Features of the conception «Training that using modulars of employable skills» (МES-conception) with reference to the organization and realization intrafirm training of workers are openedРассматривается модульный подход к организации и осуществлению внутрифирменной подготовки рабочих кадров. Определяется сущность модульного обучения и основные направления анализа понятия «модуль». Раскрываются особенности концепции «Модули трудовых навыков» применительно к организации и осуществлению внутрифирменного обучения рабочих кадро

The рersonal orientation of educational process in high school through the use of modular training

The artсle discusses the possibilities of modular technology of education based on the European concept of «Modular employs skills», from the standpoint of personal orientation of the learning process of students in technical disciplines. An example of organizing and conducting laboratory practical work on discipline «Machine tools» with use of modular technology educationВ работе рассматриваются возможности модульных технологий обучения, основанные на европейской концепции «Модули трудовых навыков», с позиций личностной ориентации процесса обучения студентов в вузе по техническим дисциплинам. Приводится пример организации и проведения лабораторного практикума по учебной дисциплине «Металлорежущие инструменты» с использованием модульной технологии обучени

Fundraising as an addendum of the effective iInnovative activity of an educational institution

The problem of fundraising in vocational education by setting up educational commercial bodies and designing industrial clusters is highlighted. The theoretical and methodological substance of the problem in question was investigated, crucial factors of various types of practice-oriented fundraising activities is suggested with special emphasis on the design of educational commercial bodies and cluster principle implementation. in successful cluster realization are defined. Implementation of the fundraising concept to ensure competitiveness of the Russian professional education by boosting an efficient innovative activity of the professional educational institution is outlined. A taxonomy of various types of practice-oriented fundraising activities is suggested with special emphasis on the design of educational commercial bodies and cluster principle implementation.Рассмотрена проблема реализации фандрайзинга в современном профессиональном образовании посредством организации образовательно-промышленных групп и проектирования промышленных кластеров. Проведен анализ теоретико-методологической базы проблемы исследования, раскрыты основные детерминанты в области реализации кластерного подхода и материализации системы фандрайзинга с целью обеспечения конкурентоспособности российского профессионального образования на основе генезиса эффективной инновационной деятельности профессиональной образовательной организации. Осуществлена таксономия различных форм воплощения в жизнь фандрайзинговой деятельности и сделан акцент на проектировании образовательно-промышленных групп и реализации кластерного подхода

Landau damping in thin films irradiated by a strong laser field

The rate of linear collisionless damping (Landau damping) in a classical electron gas confined to a heated ionized thin film is calculated. The general expression for the imaginary part of the dielectric tensor in terms of the parameters of the single-particle self-consistent electron potential is obtained. For the case of a deep rectangular well, it is explicitly calculated as a function of the electron temperature in the two limiting cases of specular and diffuse reflection of the electrons from the boundary of the self-consistent potential. For realistic experimental parameters, the contribution of Landau damping to the heating of the electron subsystem is estimated. It is shown that for films with a thickness below about 100 nm and for moderate laser intensities it may be comparable with or even dominate over electron-ion collisions and inner ionization.Comment: 15 pages, 2 figure