The relations between conscientiousness and mental health in a North-European and a West-Asian culture

Background: The relationship between conscientiousness, mental health and mental illness has been an issue for the last two decades. Aims: By using a dual model of mental health, the present study examined a non-linear relationship between conscientiousness and healthy or non-healthy symptoms in two different cultures. Method: Participants in this study were 296 Iranian and 310 Swedish university students (18-24 years of age). We used two different conscientiousness scales; the 12-item conscientiousness subscale of the NEO/FFI as an imported (etic) scale, and a 10-item Iranian conscientiousness scale as an indigenous (emic) and culture-dependent scale. Results: In both conscientiousness scales, multivariate analysis of variance showed that conscientiousness differentiated among four mental health groups (languishing, troubled, symptomatic and flourishing), although languishing and troubled individuals were less conscientious than flourishing and symptomatic individuals. Furthermore, the non-healthy symptomatic individuals were more conscientiousness than flourishing individuals. The results showed no significant differences between the two cultures in terms of the four mental health categories. Conclusions: It was concluded that the relationship between conscientiousness and mental health/mental illness is more a non-linear relationship than a linear one

Symptomatic plate removal after treatment of facial fractures

Aims: To identify the rates and reasons for plate removal (PR) among patients treated for facial fractures. Materials and methods: A retrospective review of files of 238 patients. Results: Forty-eight patients (20.2%) had plates removed. The reason for removal was objective in 33.3% and subjective in 29.2%. The most common subjective reason was cold sensitivity, and the most common objective reason was wound dehiscence/infection. Women had PR for subjective reasons more often than men (p = 0.018). Removal was performed more often for subjective reasons after zygomatico-orbital fractures than after mandibular fractures (p = 0.002). Plates inserted in the mandible from an intraoral approach were removed more frequently than extraorally inserted mandibular plates, intraorally inserted maxillary plates, and extraorally inserted plates in other locations (p < 0.001). Orbital rim plates had a higher risk of being removed than maxillary or frontal bone plates (p = 0.02). Conclusions: Subjective discomfort is a notable reason for PR among Finnish patients, suggesting that the cold climate has an influence on the need for removal. Patients receiving mandibular osteosynthesis with miniplates from an intraoral approach are at risk of hardware removal because of wound dehiscence/infection and loose/broken hardware, reminding us that more rigid fixation devices should not be forgotten despite the widespread use of miniplates. (C) 2010 European Association for Cranio-Maxillo-Facial Surger

The use of patient specific polyetheretherketone implants for reconstruction of maxillofacial deformities

Purpose: The aim of this study was to evaluate polyetheretherketone (PEEK) as a patient-specific implant (PSI) material in maxillofacial reconstructive surgery. Materials and methods: The retrospective study included a cohort of 24 patients who underwent maxillofacial surgery using PEEK PSIs. Each patient underwent preoperative multislice computed tomography (CT) with 0 degrees tilt of gantry. Based on the CT scan, the PEEK PSIs were planned and manufactured using three-dimensional (3D) modeling and computer-aided design/computer-aided manufacturing (CAD/CAM) techniques. All procedures were performed under general anesthesia. Implants were placed intraorally, extraorally or through subciliary, transconjuctival or coronal incisions. Results: In 22 of 24 cases, the PEEK PSI fit well without adjustments. Although the fit to the surrounding bone was perfect in almost all of the cases, the outer contour of the PSI was modified in nine cases before fixation. However, intraoperative implant modification did not affect the infection rate. In two cases, postoperative wound dehiscence and infection needed additional treatment and healed without removal of the implants. Conclusion: The follow-up data in this study showed good outcomes with reliable results for PSI made of PEEK in the maxillofacial region. (C) 2019 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd.Peer reviewe

Analgesic Effect of Perioperative Systemic Dexamethasone on Blowout Fracture Surgery

Purpose: To clarify the effect of systemic dexamethasone (DXM) on pain and postoperative opioid (oxycodone) consumption after blowout fracture surgery. Materials and Methods: A prospective randomized observer-blinded trial of 20 patients who had a blowout fracture requiring surgical intervention was conducted. Patients were randomly assigned to receive a total dose of intravenous DXM 30 mg perioperatively or no DXM (controls). Pain was assessed postoperatively using a 10-cm visual analog scale (VAS) each time analgesics (acetaminophen every 6 hours or oxycodone upon request) were administered. The VAS area under the curve (VAS AUC) for 24 hours postoperatively represented the outcome. Data were analyzed using chi(2) test, Student t test, 2-tailed Mann-Whitney U test, and linear regression, with a P value less than .05 indicating significance. Results: Patients with blowout fracture receiving perioperative systemic DXM exhibited a significantly lower average VAS AUC (P = .04). After controlling for other confounding variables, this result remained significant (P = .03). Conclusions: DXM appears to decrease postoperative pain and thus is recommended as a pre-emptive analgesic in blowout fracture surgery. (C) 2017 Published by Elsevier Inc on behalf of the American Association of Oral and Maxillofacial SurgeonsPeer reviewe

Non-melanoma Skin Cancer: Mini Review

Non-melanoma skin cancer (NMSC) has been frequently found in Caucasians. Basically, this type of cancer is divided into two parts, i.e. (BCC and SCC). Mutation in gene PTCH1 is one of the molecular causes involved in the disease process that plays an important role in the Sonic hedgehog signaling pathway, but the factors involving in the creation of NMCS are the ones such as age, exposure to UV ray, positive family history, male gender, genetic predisposition as well as skin color (Caucasians). In the therapeutic terms, surgery is considered as the best treatment although Radiotherapy and Cryotherapy are also used to treat but surgery is the gold standard of treatment. Immune therapy is also a new method of treatment for NMCS. In this paper, we have provided the treatment methods and have suggested the best treatment method through multiple studies.

Matrix metalloproteinase-8 and tissue inhibitor of matrix metalloproteinase-1 predict incident cardiovascular disease events and all-cause mortality in a population-based cohort

Background Extracellular matrix degrading proteases and their regulators play an important role in atherogenesis and subsequent plaque rupture leading to acute cardiovascular manifestations. Design and methods In this prospective cohort study, we investigated the prognostic value of circulating matrix metalloproteinase-8, tissue inhibitor of matrix metalloproteinase-1 concentrations, the ratio of matrix metalloproteinase-8/ tissue inhibitor of matrix metalloproteinase-1 and, for comparison, myeloperoxidase and C-reactive protein concentrations for incident cardiovascular disease endpoints. The population-based FINRISK97 cohort comprised 7928 persons without cardiovascular disease at baseline. The baseline survey included a clinical examination and blood sampling. During a 13-year follow-up the endpoints were ascertained through national healthcare registers. The associations of measured biomarkers with the endpoints, including cardiovascular disease event, coronary artery disease, acute myocardial infarction, stroke and all-cause death, were analysed using Cox regression models. Discrimination and reclassification models were used to evaluate the clinical implications of the biomarkers. Results Serum tissue inhibitor of matrix metalloproteinase-1 and C-reactive protein concentrations were associated significantly with increased risk for all studied endpoints. Additionally, matrix metalloproteinase-8 concentration was associated with the risk for a coronary artery disease event, myocardial infarction and death, and myeloperoxidase concentration with the risk for cardiovascular disease events, stroke and death. The only significant association for the matrix metalloproteinase-8/ tissue inhibitor of matrix metalloproteinase-1 ratio was observed with the risk for myocardial infarction. Adding tissue inhibitor of matrix metalloproteinase-1 to the established risk profile improved risk discrimination of myocardial infarction (p=0.039) and death (0.001). Both matrix metalloproteinase-8 (5.2%, p <0.001) and tissue inhibitor of matrix metalloproteinase-1 (12.9%, p <0.001) provided significant clinical net reclassification improvement for death. Conclusions Serum matrix metalloproteinase-8 and tissue inhibitor of matrix metalloproteinase-1 can be considered as biomarkers of incident cardiovascular disease events and death.Peer reviewe

WordCommentsAnalyzer: A windows software tool for qualitative research [version 2; referees: 2 approved]

There is a lack of free software that provides a professional and smooth experience in text editing and markup for qualitative data analysis. Word processing software like Microsoft Word provides a good editing experience, allowing the researcher to effortlessly add comments to text portions. However, organizing the keywords and categories in the comments can become a more difficult task when the amount of data increases. We present WordCommentsAnalyzer, a software tool that is written in C# using .NET Framework and OpenXml, which helps a qualitative researcher to organize codes when using Microsoft Word as the primary text markup software. WordCommentsAnalyzer provides an effective user interface to count codes, to organize codes in a code hierarchy, and to see various data extracts belonging to each code. It also offers basic visualization tools. We illustrate how to use this software by conducting a preliminary content analysis on Tweets with the #successfulaging hashtag. We also demonstrate that the software has satisfactory performance on a large dataset of Iranian journals abstracts. We hope this open-source software will facilitate qualitative data analysis by researchers who are interested in using Word for this purpose

The Effect of Biological Clock & Molecular Clock in Cancer

Nowadays change in lifestyle can most effect in our health, such as Insomnia &amp; circadian rhythm changes. In this mini-review article, we focus on the circadian rhythm changes and cancer. Our study was shown to us, existence any changes in the circadian rhythm and biological clock leads to various changes in the levels of melatonin in the human body. Melatonin in Human cells, it is responsible for the adjustment of the circadian rhythm and produced in pineal glands. Disruption in levels of melatonin definitely related to cancers, such as ovary, uterus, prostate, endometrium, leukemia, breast cancer. Circadian rhythm controlled by 8 important and mainly genes that related to apoptosis, cell cycle, and checkpoint. Changes in this genes significantly related to cancers. Finally, these results are obtained that the change in the biological clock, causing a change in the molecular clock. Following the regular sleep pattern, a major role in human health.

Cognitive impairments in patients with intractable temporal lobe epilepsy

Citation for the original published paper (version of record): Tavakoli, M., Barekatain, M., Doust, H., Molavi, H., Kormi Nouri, R. et al. (2011) Cognitive impairments in patients with intractable temporal lobe epilepsy. Sciences, 16(11): 1466Sciences, 16(11): -1472 Access to the published version may require subscription. N.B. When citing this work, cite the original published paper. Cognitive impairment associated with temporal lobe epilepsy (TLE) has been recognized in multiple studies. We designed this study to find a specific cognitive profile in patients with TLE who were candidates for epilepsy surgery. We also sought to find if neuropsychological assessment could differentiate left TLE, right TLE and normal subjects. Journal of Research in Medica