24 research outputs found
Cellular Bases of Barbiturate and Phenytoin Anticonvulsant Drug Action
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/65509/1/j.1528-1157.1982.tb06093.x.pd
A core outcome set for preāeclampsia research: an international consensus development study
Objective
To develop a core outcome set for preāeclampsia.
Design
Consensus development study.
Setting
International.
Population
Two hundred and eightāone healthcare professionals, 41 researchers and 110 patients, representing 56 countries, participated.
Methods
Modified Delphi method and Modified Nominal Group Technique.
Results
A longālist of 116 potential core outcomes was developed by combining the outcomes reported in 79 preāeclampsia trials with those derived from thematic analysis of 30 inādepth interviews of women with lived experience of preāeclampsia. Fortyāseven consensus outcomes were identified from the Delphi process following which 14 maternal and eight offspring core outcomes were agreed at the consensus development meeting. Maternal core outcomes: death, eclampsia, stroke, cortical blindness, retinal detachment, pulmonary oedema, acute kidney injury, liver haematoma or rupture, abruption, postpartum haemorrhage, raised liver enzymes, low platelets, admission to intensive care required, and intubation and ventilation. Offspring core outcomes: stillbirth, gestational age at delivery, birthweight, smallāforāgestationalāage, neonatal mortality, seizures, admission to neonatal unit required and respiratory support.
Conclusions
The core outcome set for preāeclampsia should underpin future randomised trials and systematic reviews. Such implementation should ensure that future research holds the necessary reach and relevance to inform clinical practice, enhance women's care and improve the outcomes of pregnant women and their babies