Coincidence between transcriptome analyses on different microarray platforms using a parametric framework

A parametric framework for the analysis of transcriptome data is demonstrated to yield coincident results when applied to data acquired using two different microarray platforms. Discrepancies among transcriptome studies are frequently reported, casting doubt on the reliability of collected data. The inconsistency among observations can be largely attributed to differences among the analytical frameworks employed for data analysis. The existing frameworks normalizes data against a standard determined from the data to be analyzed. In the present study, a parametric framework based on a strict model for normalization is applied to data acquired using an in-house printed chip and GeneChip. The framework is based on a common statistical characteristic of microarray data, and each data is normalized on the basis of a linear relationship with this model. In the proposed framework, the expressional changes observed and genes selected are coincident between platforms, achieving superior universality of data compared to other methods

Simple Scheme for Gauge Mediation

We present a simple scheme for constructing models that achieve successful gauge mediation of supersymmetry breaking. In addition to our previous work [1] that proposed drastically simplified models using metastable vacua of supersymmetry breaking in vector-like theories, we show there are many other successful models using various types of supersymmetry breaking mechanisms that rely on enhanced low-energy U(1)_R symmetries. In models where supersymmetry is broken by elementary singlets, one needs to assume U(1)_R violating effects are accidentally small, while in models where composite fields break supersymmetry, emergence of approximate low-energy U(1)_R symmetries can be understood simply on dimensional grounds. Even though the scheme still requires somewhat small parameters to sufficiently suppress gravity mediation, we discuss their possible origins due to dimensional transmutation. The scheme accommodates a wide range of the gravitino mass to avoid cosmological problems.Comment: 13 page

Two hadron production in e+e- annihilation to next-to-leading order accuracy

We discuss the production of two hadrons in e+e- annihilation within the framework of perturbative QCD. The cross section for this process is calculated to next-to-leading order accuracy with a selection of variables that allows the consideration of events where the two hadrons are detected in the same jet. In this configuration we contemplate the possibility that the hadrons come from a double fragmentation of a single parton. The double-fragmentation functions required to describe the transition of a parton to two hadrons are also necessary to completely factorize all collinear singularities. We explicitly show that factorization applies to next-to-leading order in the case of two-hadron production.Comment: 13 pages, 4 figure