The Role of Multifunctional T cells in IL-10 Deficient CBA/J Mice Infected with Mycobacterium tuberculosis

Mayers Summer Research Scholarship2012 Denman Undergraduate Research Forum. 1st Place in Biological Sciences.Most humans infected with Mycobacterium tuberculosis (M.tb) can exhibit asymptomatic control of the infection however, 10% of humans can reactivate infection to develop contagious tuberculosis (TB). IL-10 is an immunosuppressive cytokine that has been hypothesized to play a role in the reactivation of M.tb infection. Previous studies have shown that CBA/J IL10 knockout mice can better control M.tb infection compared to wild type CBA/J mice. This has been noted by a measured decrease in the pulmonary bacterial load throughout infection, an increase in survival compared to M.tb-infected CBA/J mice, and enhanced early TH1 mediated immune responses. Multifunctional CD4+ T cells, T cells that produce IFN-γ, TNF-α, and IL-2, have recently been linked to control of M.tb infection. The goal of this project was to analyze multifunctional T cells in the CBA/J mouse strain, a strain that is naturally susceptible to M.tb, as well as in CBA/J IL-10 knockout mice. The mediastinal lymph node of CBA/J mice and CBA/J IL10 knockout mice was analyzed early in infection for the presence of multifunctional CD4+ T cells. Our hypothesis was the IL-10 knockout mice would show higher numbers of T cells as well as more T cells with the ability to produce multiple pro-inflammatory cytokines at early time points in infection. It was found that the CBA/J IL10 knockout mice possessed more CD4+ T cells with the ability to produce one, two, or three of the protective cytokines. Therefore, the presence of multifunctional CD4 T cells may be linked with improved control of M.tb infection, a finding that could lead to further therapeutic development.NIH NIAID grant R01 AI064522No embarg

Alien Registration- Kominsky, Sadye (Bangor, Penobscot County)

https://digitalmaine.com/alien_docs/11853/thumbnail.jp

The Bunch’s Power Pak Comics (No. 2)

The Adler Archive of Underground Comix, Gift of Bill Adler.https://digitalcommons.risd.edu/specialcollections_adlerarchive_undergroundcomix/1018/thumbnail.jp

The Bunch’s Power Pak Comics (No. 1)

The Adler Archive of Underground Comix, Gift of Bill Adler.https://digitalcommons.risd.edu/specialcollections_adlerarchive_undergroundcomix/1017/thumbnail.jp

The Bunch’s Power Pak Comics (No. 2)

The Adler Archive of Underground Comix, Gift of Bill Adler.https://digitalcommons.risd.edu/specialcollections_adlerarchive_undergroundcomix/1018/thumbnail.jp

Arquivo e banco de dados: poética, ética e estética da visualização artística

A partir do exemplo de obras que trafegam pelo conceito de arquivo, pela forma simbólica do banco de dados, e da constituição de visualizações, discutimos neste artigo as articulações desenvolvidas por esses modelos dentro do campo da arte, suas questões éticas e potencialidades estéticas e poéticas

Weirdo, No. 18

28 volumes : illustrations. Frequency: quarterly. Publication dates: No. 1 (spring, 1981), ceased with no. 28 (summer, 1993). Editor: R. Crumb. With issue #10, P. Bagge became editor; with issue #18, Crumb\u27s wife, Aline Kominsky-Crumb became editor (except for issue #25, which was again edited by Bagge).Color illustrations on covers, b&w interiors. Early issues of Weirdo reflect Crumb\u27s interests at the time outsider art, fumetti, Church of the SubGenius-type anti-propaganda and assorted weirdness. It also introduced artists such as Peter Bagge, Dori Seda and Dennis Worden. No. 18 Contributors: Robert Crumb, Diane Noomin, Peter Bagge, Justin Green, Michael Dougan, Aline Kominsky-Crumb, Dori Seda, Spain Rodriguez, Linda Crothers, Carol Tyler, and more. Library has two copies of no. 27. The Adler Archive of Underground Comix, Gift of Bill Adler.https://digitalcommons.risd.edu/specialcollections_adlerarchive_undergroundcomix/1117/thumbnail.jp

Weirdo, No. 26

28 volumes : illustrations. Frequency: quarterly. Publication dates: No. 1 (spring, 1981), ceased with no. 28 (summer, 1993). Editor: R. Crumb. With issue #10, P. Bagge became editor; with issue #18, Crumb\u27s wife, Aline Kominsky-Crumb became editor (except for issue #25, which was again edited by Bagge).Color illustrations on covers, b&w interiors. Early issues of Weirdo reflect Crumb\u27s interests at the time outsider art, fumetti, Church of the SubGenius-type anti-propaganda and assorted weirdness. It also introduced artists such as Peter Bagge, Dori Seda and Dennis Worden. No. 26 Contributors: Robert Crumb, Diane Noomin, Mary Fleener, Leslie Sternbergh, Lloyd Dangle, Penny Moran, Phoebe Gloeckner, Spain Rodriguez, Aline Kominsky-Crumb, Roy Tompkins, Stanley Goldstein, Ted Jouflas, Julie Doucet, Krystine Kryttre, and more. Library has two copies of no. 27. The Adler Archive of Underground Comix, Gift of Bill Adler.https://digitalcommons.risd.edu/specialcollections_adlerarchive_undergroundcomix/1124/thumbnail.jp

Weirdo, No. 28

28 volumes : illustrations. Frequency: quarterly. Publication dates: No. 1 (spring, 1981), ceased with no. 28 (summer, 1993). Editor: R. Crumb. With issue #10, P. Bagge became editor; with issue #18, Crumb\u27s wife, Aline Kominsky-Crumb became editor (except for issue #25, which was again edited by Bagge).Color illustrations on covers, b&w interiors. Cover title of no. 28 (Summer 1993) entitled Verre d\u27eau [Glass of water] and called one-time-only special international issue, absolutely the last issue ever. Early issues of Weirdo reflect Crumb\u27s interests at the time outsider art, fumetti, Church of the SubGenius-type anti-propaganda and assorted weirdness. It also introduced artists such as Peter Bagge, Dori Seda and Dennis Worden. No. 28 Contributors: Robert Crumb, Robert Armstrong, Sasa Rekezic, Roy Tompkins, Florence Cestac, Ted Jouflas, Bill Griffith, Debbie Drechsler, Jean-Christoph Menu, Spain Rodriguez, Placid, Peter Bagge, Baudoin Diane Noomin, Willem, Aline Kominsky-Crumb, Caroline Wedier, Carol Tyler Matt Konture, Phoebe Gloeckner, Mary Fleener, Bob Kathman, Sasa Rakezic, and more. Library has two copies of no. 27. The Adler Archive of Underground Comix, Gift of Bill Adler.https://digitalcommons.risd.edu/specialcollections_adlerarchive_undergroundcomix/1126/thumbnail.jp