Efficacy of Phytoextracts on Female Reproduction and Impact on Diabetes Mellitus

Diabetes is linked to a wide range of reproductive health problems, including delayed puberty and menarche, irregular menstruation, decreased fertility, unfavorable pregnancy outcomes, and perhaps an early menopause. Depending on the age of the diabetes diagnosis, these issues may appear during puberty, later when fertility is desired, or even during the menopause transition. In the past, amenorrhea and infertility in women with type 1 diabetes were frequently brought on by central hypogonadism. Although these problems have decreased as a result of improvements in metabolic regulation and insulin therapy, they still exist. Other reproductive effects of modern diabetes therapy, like polycystic ovarian syndrome and hyperandrogenism, influenced by insulin's action on the ovaries, have also come to light. Type 2 diabetes is becoming increasingly common in young people, which suggests that more women who are of reproductive age will face difficulties getting pregnant as a result of their diabetes. Healthcare professionals need to be knowledgeable and ready to handle the difficulties of managing reproductive health issues across the lifetime as the number of young women with diabetes keeps growing. Plant-based phytoextracts have drawn interest as potential alternative therapies for controlling diabetes and enhancing reproductive outcomes. According to studies, several phytoextracts may have qualities including insulin sensitization, anti-inflammatory activity, and antioxidants that are good for female reproductive health. Understanding the interactions between female reproductive physiology and diabetes can help overall, and phytoextract supplementation may offer valuable insights into developing personalized and effective interventions to enhance reproductive outcomes and the overall well-being of women with diabetes. This review aims to provide a comprehensive overview of the physiology of female reproduction in the context of diabetes mellitus and investigate the potential impact of phytoextract supplementation on reproductive outcomes. By synthesizing existing literature, the aim is to highlight the pathophysiological mechanisms underlying the adverse effects of diabetes on the female reproductive system and explore the potential benefits of natural plant-derived compounds in mitigating these effect

ANTI-DIABETIC ACTIVITY OF TRADITIONAL POLYHERBAL FORMULATION: DEVELOPMENT AND EVALUATION

Herbal therapy has emerged as a prominent therapeutic approach for a wide range of ailments. In tandem with a nutritious diet and lifestyle, these interventions aim to address certain health objectives by supplying each cell with the most suitable and advantageous nourishment. There exists a botanical alternative for each synthetic medicine now available. Material and Methods: The herbs utilized in the formulation were obtained from reputable vendors and subsequently verified by Department of Life Sciences, Garden City University, Bengaluru, Karnataka, India. For the purpose of standardizing raw materials, shade-dried powdered plant parts from the plants Berberis aristata (dried stem), Terminalia chebula (pericarp of matured fruit), Emblica officinalis (pericarp of dried mature fruit), Terminalalia belerica (pericarp of dried ripe fruit), and Cyperus rotundus (dried rhizome) are used. Results: Blood glucose and lipid profiles were taken first thing in the morning. The formulation had a significant impact when compared to the typical range before diabetes was introduced. Total cholesterol, bad LDL cholesterol, and bad triglyceride levels were all reduced while HDL levels were increased. The phytochemical investigation backed up the claim that flavonoids were present. This may explain why it has such a dramatic impact on treating diabetes. It is recommended that future clinical trials be conducted in Human Volunteers, and that stability studies be conducted on the manufactured polyherbal capsules. Conclusion: The oldest type of therapy, herbal remedies are used to identify and treat illnesses. An animal model was used to assess the antidiabetic potency of five raw materials that were chosen for formulation into polyherbal capsules. The capsules significantly improved the lipid profile and fasting blood glucose indices, as well as their anti-diabetic efficacy. Future use is advised to pursue additional stability research and clinical trials

To Study of Artemisia nilagirica Leaves for their Antithyroid, Oxidative and Antihyperglycemic Properties

The tiny, fragrant shrub Artemisia nilagirica (Clarke) is a member of the Asteraceae family. This plant's leaves and flowering top have been used in traditional medicine as an antimalarial, nerve tonic, and anticancer drug, and there is evidence of anti-leishmanial efficacy. Material and Methods: The plant specimen was obtained from the Ooty district in Tamil Nadu, India, during the month of December. It was subsequently authenticated by NMKRV College for Women, Bengaluru, Karnataka, India. The plant specimens were stored in the herbarium of the NMKRV College for Women, Bengaluru, Karnataka, India. Results: The morphological, microscopic, organoleptic, and other WHO-recommended procedures for standardization were investigated in a powdered sample of Artemisia nilagirica (Clarke) leaf. Phytochemical investigation revealed the existence of numerous elements such as alkaloids, amino acids, carbohydrates, flavonoids, glycosides, terpenoids, steroids, saponins, essential oils, tannins and phenol in diverse extracts. Conclusion: Pharmacognostic and phytochemical analysis of Artemisia nilagirica (Clarke) leaves would be useful for authenticating raw material or crude medication

A pharmacological evaluation of ethanol extract of alpinia calcarata rhizome for anti-oxidant, anti-inflammatory and anti-asthmatic properties

Alpinia calcarata rhizome ethanolic extract was tested for anti-asthmatic, antioxidant, and anti-inflammatory properties. Adaptogens normalize leukocytosis after milk consumption. Eosinophils are necessary for allergic illness development. The plant extract significantly reduced allergic asthma-related eosinophil cell count compared to the control group. Eosinophil count decreases cell recruitment and IL-4, IL-5, and IL-13, which affect cell count. Studies on milk-induced leukocytosis and eosinophils verified the plant extract's anti-asthmatic capabilities. In guinea pigs, goats, horses, dogs, and humans, histamine contracts trachea and bronchial muscles. Tracheas in guinea pigs test asthma drugs. The isolated guinea pig trachea contracts dose-dependently after H1 receptor stimulation. Alpinia calcarata reduced histamine-induced trachea constriction in solitary guinea pigs, proving its anti-asthmatic and H1 receptor antagonist capabilities. Hydrogen peroxide scavenging and reduction were used to test antioxidants. A hydrogen peroxide-scavenging Alpinia calcarata rhizome ethanol extract. Hydrogen peroxide scavenged less than ascorbic acid. Increasing Alpinia calcarata rhizome ethanolic extract dramatically lowered power. In vitro, ethanolic Alpinia calcarata rhizome extract stabilized rabbit red blood cell membranes and prevented protein denaturation. The ethanolic Alpinia calcarata rhizome extract was anti-asthmatic. Antioxidant and anti-inflammatory characteristics aid the plant's anti-astatic effects. Most asthma medications are steroidal. The phytochemical study identified steroids and flavonoids. Chemical moieties may make the plant anti-asthmatic. The findings support the conventional and advise more anti-asthmatic active component study

Anti-Urolithiatic Activity of Cassia Auriculata Ethanolic Seed Extract in Wistar Rats

Background: Urolithiasis is a medical condition that, despite substantial research in the field of urology, has yet to find a cure within the allopathic medical approach. The process of stone development, known as nephrolithiasis, can occur within the kidney or any segment of the urinary tract, encompassing the ureters and bladder. Material and Methods: The seeds of Cassia auriculata (Linn.) were obtained in June 2021 from Mettukadai hamlet, located in the Erode District of Tamilnadu, India. The herbarium of the plant was meticulously assembled, verified, and afterwards deposited as a voucher specimen. The voucher specimen was retained within the college premises for future reference. Results: The current investigation involved conducting a preliminary phytochemical analysis on the ethanolic seed extract of Cassia auriculata Linn. The research revealed the existence of many phytochemical constituents, including Alkaloids, Flavanoids, Carbohydrate, Sterols, Phytosterols, Phenols, Terpenoids, Amino acids, and Anthraquinones. The acute toxicity experiments revealed that rats exhibited tolerance to a maximum dose of 2000 mg/kg body weight, and no discernible alterations in behavior were detected across all experimental groups. Hence, fractions equivalent to one-fourth and one-eighth of the maximum tolerated dose of 200 mg/kg body weight were selected for subsequent investigations. Conclusion: In summary, the findings suggest that the application of an ethanolic seed extract derived from Cassia auriculata Linn effectively decreased the progression of urinary stone formation. Additionally, it appears that the efficacy of the treatment impact surpasses that of its preventative counterpart