Intramural pure pigment gall­stones, a case report

A case of intramural pure pigment gallstones, which were fortuitously found in post-mortem examination, is presented. The incidence, mechanism of formation of the stones and roentgenological diagnosis of the intramural gallstones, porcelain gall bladder, are mentioned.</p

Paroxysmal bundle branch block a case of two to one right bundle branch block followed by intermit­tent right bundle branch block

A case of paroxysmal bundle branch block, two to one right bundle branch block followed by intermittent right bundle branch block, which is associated with chronic cor pulmonale secondary to active, far advanced pulmonary tuberculosis, is presented. The incidence and mechanism of the paroxysmal bundle branch block have been discussed.</p

Envy-freeness and maximum Nash welfare for mixed divisible and indivisible goods

We study fair allocation of resources consisting of both divisible and indivisible goods to agents with additive valuations. When only divisible or indivisible goods exist, it is known that an allocation that achieves the maximum Nash welfare (MNW) satisfies the classic fairness notions based on envy. In addition, properties of the MNW allocations for binary valuations are known. In this paper, we show that when all agents' valuations are binary and linear for each good, an MNW allocation for mixed goods satisfies the envy-freeness up to any good for mixed goods. This notion is stronger than an existing one called envy-freeness for mixed goods (EFM), and our result generalizes the existing results for the case when only divisible or indivisible goods exist. Moreover, our result holds for a general fairness notion based on minimizing a symmetric strictly convex function. For the general additive valuations, we also provide a formal proof that an MNW allocation satisfies a weaker notion than EFM

Fair Allocation with Binary Valuations for Mixed Divisible and Indivisible Goods

The fair allocation of mixed goods, consisting of both divisible and indivisible goods, among agents with heterogeneous preferences, has been a prominent topic of study in economics and computer science. In this paper, we investigate the nature of fair allocations when agents have binary valuations. We define an allocation as fair if its utility vector minimizes a symmetric strictly convex function, which includes conventional fairness criteria such as maximum egalitarian social welfare and maximum Nash social welfare. While a good structure is known for the continuous case (where only divisible goods exist) or the discrete case (where only indivisible goods exist), deriving such a structure in the hybrid case remains challenging. Our contributions are twofold. First, we demonstrate that the hybrid case does not inherit some of the nice properties of continuous or discrete cases, while it does inherit the proximity theorem. Second, we analyze the computational complexity of finding a fair allocation of mixed goods based on the proximity theorem. In particular, we provide a polynomial-time algorithm for the case when all divisible goods are identical and homogeneous, and demonstrate that the problem is NP-hard in general. Our results also contribute to a deeper understanding of the hybrid convex analysis

Communication-Fabrication of a Uniformly Tin-Coated Three-Dimensional Copper Nanostructured Architecture by Electrodeposition

A three-dimensional copper nanostructure architecture (3DC1) coated uniformly with a tin film was fabricated by electrodeposition. In these trials, a pyrophosphate bath was used for tin plating, and the effects of polyethylene glycol and formaldehyde additives on the morphology of the deposited tin were investigated. Relatively large tin particles were electrodeposited in an inhomogeneous manner over the 3DC1 surface when using a plating bath without additives. In contrast, 3DC1 coated with a uniformly thick tin film was fabricated by employing a bath with the additives. (C) The Author(s) 2015. Published by ECS.ArticleJOURNAL OF THE ELECTROCHEMICAL SOCIETY. 163(2):D54-D56 (2016)journal articl

Influence of processing conditions of atmospheric freeze-drying/low-temperature drying on the drying kinetics of sliced fruits and their vitamin C retention

Sliced fruits (apple and kiwi) were dried under atmospheric freeze-drying (AFD) and/or low-temperature drying (LTD) conditions, and the drying kinetics, resultant degree of shrinkage, and vitamin C retention were evaluated. The air temperature programs were set in the range of −20 to 10 °C, and the impact of the sub-zero temperature setting was investigated. As expected, shortening the sub-zero temperature time and increasing the air temperature led to a shorter total drying time. Notably, the application of freezing had an effect to reduce the drying time. The application of the LTD condition without freezing significantly increased the total drying time compared with that of the drying condition with freezing. When the temperature was increased stepwise from −20 to 10 °C, the total drying time was effectively reduced when the sub-zero temperature was maintained for a relatively long time. This was the most practical drying program for maintaining product quality. It was found that drying at sub-zero temperatures has advantages in reducing product shrinkage; however, the impact was not remarkable. The application of sub-zero temperature conditions was advantageous for vitamin C retention for both apple and kiwi drying. However, if the negative effect of freezing on quality is significant, simple LTD conditions may be a good compromise for balancing total drying time and product quality

Dyspnoea with activities of daily living versus peak dyspnoea during exercise in male patients with COPD

SummaryDyspnoea measurements in chronic obstructive pulmonary disease (COPD) can be broadly divided into two categories: those that assess breathlessness during exercise, and those that assess breathlessness during daily activities. We investigated the relationships between dyspnoea at the end of exercise and during daily activities with clinical measurements and mortality in COPD patients.We examined 143 male outpatients with moderate to very severe COPD. The peak Borg score at the end of progressive cycle ergometry was used for the assessment of peak dyspnoea rating during exercise, and the Baseline Dyspnea Index (BDI) score was used for dyspnoea with activities of daily living. Relationships between these dyspnoea ratings with other clinical measurements of pulmonary function, exercise indices, health status and psychological status were then investigated. In addition, their relationship with the 5-year mortality of COPD patients was also analyzed to examine their predictive ability.Although the BDI score was significantly correlated with airflow limitation, diffusing capacity, exercise indices, health status and psychological status, the Borg score at the end of exercise had non-existent or only weak correlations with them. The BDI score was strongly significantly correlated with mortality, whereas the Borg score was not.Dyspnoea during daily activities was more significantly correlated with objective and subjective measurements of COPD than dyspnoea at the end of exercise. In addition, the former was more predictive of mortality. Dyspnoea with activities of daily living is considered to be a better measurement for evaluating the disease severity of COPD than peak dyspnoea during exercise

Early Development of Resident Macrophages in the Mouse Cochlea Depends on Yolk Sac Hematopoiesis

Resident macrophages reside in all tissues throughout the body and play a central role in both tissue homeostasis and inflammation. Although the inner ear was once believed to be “immune-privileged, ” recent studies have shown that macrophages are distributed in the cochlea and may play important roles in the immune system thereof. Resident macrophages have heterogeneous origins among tissues and throughout developmental stages. However, the origins of embryonic cochlear macrophages remain unknown. Here, we show that the early development of resident macrophages in the mouse cochlea depends on yolk sac hematopoiesis. Accordingly, our results found that macrophages emerging around the developing otocyst at E10.5 exhibited dynamic changes in distribution and in situ proliferative capacity during embryonic and neonatal stages. Cochlear examination in Csf1r-null mice revealed a substantial decrease in the number of Iba1-positive macrophages in the spiral ganglion and spiral ligament, whereas they were still observed in the cochlear mesenchyme or on the intraluminal surface of the perilymphatic space. Our results demonstrated that two subtypes of resident macrophages are present in the embryonic cochlea, one being Csf1r-dependent macrophages that originate from the yolk sac and the other being Csf1r-independent macrophages that appear to be derived from the fetal liver via systemic circulation. We consider the present study to be a starting point for elucidating the roles of embryonic cochlear resident macrophages. Furthermore, resident macrophages in the embryonic cochlea could be a novel target for the treatment of various inner ear disorders

A display of pH-sensitive fusogenic GALA peptide facilitates endosomal escape from a Bio-nanocapsule via an endocytic uptake pathway

BACKGROUND: An affibody-displaying bio-nanocapsule (Z(HER2)-BNC) with a hepatocyte specificity derived from hepatitis B virus (HBV) was converted into an affibody, Z(HER2), that recognizes HER2 receptors. This affibody was previously reported to be the result of the endocytosis-dependent specific uptake of proteins and siRNA into target cancer cells. To assist the endosomal escape of inclusions, a helper lipid with pH-sensitive fusogenic ability (1,2-dioleoyl-sn-glycero-3-phos phoethanolamine; DOPE) was conjugated with a Z(HER2)-BNC. FINDINGS: In this study, we displayed a pH-sensitive fusogenic GALA peptide on the surface of a particle in order to confer the ability of endosomal escape to a Z(HER2)-BNC. A GALA-displaying Z(HER2)-BNC purified from yeast uneventfully formed a particle structure. Furthermore, endosomal escape of the particle was facilitated after endocytic uptake and release of the inclusions to the cytoplasm without the cell toxicity. CONCLUSION: The genetic fusion of a GALA peptide to the virus-like particle confers the ability of endosomal escape