Factors of research groups’ productivity: The case of the Ural Federal University

Relevance. One of the main goals of state university support programs in Russia is to increase the number of scientific publications. In 2021, Project 5-100 was replaced by the program PRIORITY 2030 (Strategic Academic Leadership Program). The new program increased the significance of the factors affecting the number of publications in universities and the issue of the optimal allocation of funding among research groups.Research objective. This study examines the factors that affect the productivity of research groups at the university. Unlike the majority of other studies on this topic, this study analyzes scientific productivity at the level of research groups.Data and methods. The study was possible due to the availability of data for 79 research groups at the Ural Federal University for the period from 2014 to 2020. The total number of articles and the number of articles in journals with an impact factor of more than two were used as indicators of research groups’ performance. To determine the factors influencing these indicators, we used econometric models for panel data. We used two separate samples: for social sciences and humanities and for other sciences.Results. We identified the following factors affecting the performance of research groups: the number of participants, the age of the research group, the supervisor’s scientific age, and the amount of funding (the possibility of obtaining more funds or being denied funds). The most interesting result is the following: the supervisor's scientific age and increased funding have a negative impact on the group’s performance. The article provides possible explanations for these results.Conclusion. Since the purpose of creating and funding research groups is primarily to increase their productivity, the results may be in favor of younger supervisors. University managers may also be interested in the ambiguous impact of increased funding: we suppose that research groups are more motivated not by the actual funding but by the prospective amount they may get

Analysis of C/E results of fission rate ratio measurements in several fast lead VENUS-F cores

During the GUINEVERE FP6 European project (2006-2011), the zero-power VENUS water-moderated reactor was modified into VENUS-F, a mockup of lead cooled fast spectrum system with solid components that can be operated in both critical and subcritical mode. The Fast Reactor Experiments for hybrid Applications (FREYA) FP7 project was launched in 2011 to support the designs of the MYRRHA Accelerator Driven System (ADS) and the ALFRED Lead Fast Reactor (LFR). Three VENUS-F critical core configurations, simulating the complex MYRRHA core design and one configuration devoted to the LFR ALFRED core conditions were investigated in 2015. The MYRRHA related cores simulated step by step design peculiarities like the BeO reflector and in pile sections. For all of these cores the fuel assemblies were of a simple design consisting of 30 % enriched metallic uranium, lead rodlets to simulate the coolant and Al2O3 rodlets to simulate the oxide fuel. Fission rate ratios of minor actinides such as Np-237, Am-241 as well as Pu-239, Pu-240, Pu-242 and U-238 to U-235 were measured in these VENUS-F critical assemblies with small fission chambers in specially designed locations, to determine the spectral indices in the different neutron spectrum conditions. The measurements have been analyzed using advanced computational tools including deterministic and stochastic codes and different nuclear data sets like JEFF-3.1, JEFF-3.2, ENDF/B7.1, ENDF/B6.8, JENDL-4.0 and TENDL-2014. The analysis of the C/E discrepancies will help to improve the nuclear data in the specific energy region of fast neutron reactor spectra

DIGITAL TRANSFORMATION OF COMPANIES AS A TOOL OF CRISIS MANAGEMENT: АN EMPIRICAL RESEARCH OF THE IMPACT ON EFFICIENCY

The economic crisis generated by the coronavirus pandemic has acted as an accelerator for the digital transformation of almost all economic entities, as a result of which it has become a massive phenomenon. However, this situation has shown that the practical development of digital transformation as a tool for business management in the digital economy requires its theoretical understanding, the formation of a theoretical basis and a scientific definition of the essence of digital transformation of companies. In particular, one of the key problems in the implementation of digital transformation at the present time is the assessment of its effectiveness, since in most cases it does not always end successfully. At the same time, knowledge of approaches and criteria for the effectiveness of digital transformation can improve the quality of its implementation. The purpose of the study is to study approaches to assessing the effectiveness of digital transformation, to determine its nature and essence at a theoretical level, as well as to conduct an econometric analysis of the contribution of digital transformation to achieving the company's efficiency.In the course of the study the existing approaches to defining the essence of digital transformation were studied, its key elements that make up the basis were established, and the existing approaches to assessing the effectiveness of digital transformation of a company and its impact on business efficiency were studied. The absence of a unified approach to assessing the effectiveness of digital transformation and the main reasons for this problem have been established. Based on the results of the regression analysis of a sample of the largest companies of the pre-digital era, implementing digital transformation, the formulated hypothesis about the impact of digital transformation on the short-term performance of the company (profitability) was refuted, which allowed us to assume the strategic nature of this tool, the results of which are formed over a lag of time.When writing the article, various scientific research methods were used: deduction and induction when conducting empirical analysis of the activities of companies implementing digital transformation, analytical methods and regression analysis.The obtained results of the study contribute to the development of the theory of assessing the effectiveness of digital transformation of business, anti-crisis management and determine the directions for further theoretical developments

Oxidative Stress during HIV Infection : Mechanisms and Consequences

Publisher Copyright: © 2016 Alexander V. Ivanov et al.It is generally acknowledged that reactive oxygen species (ROS) play crucial roles in a variety of natural processes in cells. If increased to levels which cannot be neutralized by the defense mechanisms, they damage biological molecules, alter their functions, and also act as signaling molecules thus generating a spectrum of pathologies. In this review, we summarize current data on oxidative stress markers associated with human immunodeficiency virus type-1 (HIV-1) infection, analyze mechanisms by which this virus triggers massive ROS production, and describe the status of various defense mechanisms of the infected host cell. In addition, we have scrutinized scarce data on the effect of ROS on HIV-1 replication. Finally, we present current state of knowledge on the redox alterations as crucial factors of HIV-1 pathogenicity, such as neurotoxicity and dementia, exhaustion of CD4+/CD8+ T-cells, predisposition to lung infections, and certain side effects of the antiretroviral therapy, and compare them to the pathologies associated with the nitrosative stress.publishersversionPeer reviewe

Oxidative stress, a trigger of hepatitis C and B virus-induced liver carcinogenesis

Virally induced liver cancer usually evolves over long periods of time in the context of a strongly oxidative microenvironment, characterized by chronic liver inflammation and regeneration processes. They ultimately lead to oncogenic mutations in many cellular signaling cascades that drive cell growth and proliferation. Oxidative stress, induced by hepatitis viruses, therefore is one of the factors that drives the neoplastic transformation process in the liver. This review summarizes current knowledge on oxidative stress and oxidative stress responses induced by human hepatitis B and C viruses. It focuses on the molecular mechanisms by which these viruses activate cellular enzymes/systems that generate or scavenge reactive oxygen species (ROS) and control cellular redox homeostasis. The impact of an altered cellular redox homeostasis on the initiation and establishment of chronic viral infection, as well as on the course and outcome of liver fibrosis and hepatocarcinogenesis will be discussed The review neither discusses reactive nitrogen species, although their metabolism is interferes with that of ROS, nor antioxidants as potential therapeutic remedies against viral infections, both subjects meriting an independent review.publishersversionPeer reviewe